Drug General Information
Drug ID
D0D4YZ
Former ID
DCL001224
Drug Name
PSI-7977
Drug Type
Small molecular drug
Indication HCV genotypes 1-6 [ICD10:B17.1, B18.2] Approved [889440]
HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2] Phase 2 [551499]
Company
Gilead Sciences
Structure
Download
2D MOL

3D MOL

Formula
C22H29FN3O9P
Canonical SMILES
CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F<br />)O)OC3=CC=CC=C3
InChI
1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1
InChIKey
TTZHDVOVKQGIBA-IQWMDFIBSA-N
PubChem Compound ID
PubChem Substance ID
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Hepatitis C virus NS5B polymerase Target Info Modulator [532651]
References
Ref 5514992011 Pipeline of Pharmasset.
Ref 8894402016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.
Ref 5326512013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.

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