Drug General Information
Drug ID
D0H3WI
Former ID
DAP000173
Drug Name
Ribavirin
Synonyms
Copegus; Cotronak; RBV; RTC; RTCA; Ravanex; Rebetol; Rebetron; Rebretron; Ribacine; Ribamide; Ribamidil; Ribamidyl; Ribasphere; Ribav; Ribavirina; Ribavirine; Ribavirinum; Ribovirin; Tribavirin; Varazid; Vilona; Viramid; Viramide; Virazid; Virazide; Virazole; Ribavirin Capsules; R 9644; SCH 18908; C-Virin; Copegus (TN); DRG-0028; Drug: Ribavirin; ICN-1229; KS-1104; R-964; RG-964; Rebetol (TN); Ribasphere (TN); Ribavirin [USAN:INN]; Ribavirina [INN-Spanish]; Ribavirine [INN-French]; Ribavirinum [INN-Latin]; Vilona (TN); Virazole (Ribavirin) Inhalation Solution; Virazole (TN); AA-504/07617051; Ro 20-9963/000; Ro-20-9963; Ribavirin (JAN/USP/INN); 1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide; 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide; 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide; 1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
Drug Type
Small molecular drug
Indication HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2] Approved [538312], [541922]
Therapeutic Class
Antiviral Agents
Company
Hoffmann-La Roche pharmaceutical company
Structure
Download
2D MOL

3D MOL

Formula
C8H12N4O5
InChI
InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
InChIKey
IWUCXVSUMQZMFG-AFCXAGJDSA-N
CAS Number
CAS 36791-04-5
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
J05AB04
SuperDrug CAS ID
cas=036791045
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Inosine-5'-monophosphate dehydrogenase Target Info Inhibitor [536140], [536154]
References
Ref 538312FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076192.
Ref 541922(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6842).
Ref 536140A randomized, double-blind, placebo-controlled dose-escalation trial of merimepodib (VX-497) and interferon-alpha in previously untreated patients with chronic hepatitis C. Antivir Ther. 2005;10(5):635-43.
Ref 536154Treating HCV with ribavirin analogues and ribavirin-like molecules. J Antimicrob Chemother. 2006 Jan;57(1):8-13. Epub 2005 Nov 17.

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