Target Information

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Target General Information
Drugs and Modes of Action
Drug Binding Sites of Target
Different Human System Profiles of Target
References
Drug Binding Sites of Target  Top
Ligand Name: Ademetionine Ligand Info
Structure Description Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionine PDB:2NYU
Method X-ray diffraction Resolution 1.76 Å Mutation Yes [2]
PDB Sequence
SYRSRSAFKL
10
LEVNERHQIL
20
RPGLRVLDCG
30
AAPGAWSQVA
40
VQKVNAAGTD
50

PSSPVGFVLG
60
VDLLHIFPLE
70
GATFLCPADV
80
TDPRTSQRIL
90
EVLPGRRADV
100

ILSDMAPNAT
110
GFRDLDHDRL
120
ISLCLTLLSV
130
TPDILQPGGT
140
FLCKTWAGSQ
150

SRRLQRRLTE
160
EFQNVRIIKP
170
EVYFLATQYH
188
G
Residue
Distance (Å)
SER4
4.265
SER6
3.468
ALA7
4.765
ASP28
4.851
GLY30
2.900
ALA31
3.510
ALA32
3.067
PRO33
3.067
GLY34
2.997
ALA35
2.915
TRP36
2.866
VAL61
4.397
ASP62
2.660
Residue
Distance (Å)
LEU63
3.482
LEU64
3.668
ALA78
3.415
ASP79
2.899
VAL80
2.892
THR81
4.052
ASP104
2.884
MET105
3.363
ALA106
3.192
PRO107
4.740
LEU123
3.965
LYS144
3.535
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.

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