Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T98917 Target Info
Target Name Mitochondrial rRNA methyltransferase 2 (MRM2)
Synonyms rRNA methyltransferase 2, mitochondrial; Protein ftsJ homolog 2; 16S rRNA [Um1369] 2'-O-methyltransferase; 16S rRNA (uridine(1369)-2'-O)-methyltransferase
Target Type Successful Target
Gene Name MRM2
Biochemical Class Methyltransferase
UniProt ID
MRM2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Ademetionine Ligand Info
Structure Description Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionine PDB:2NYU
Method X-ray diffraction Resolution 1.76 Å Mutation Yes [1]
PDB Sequence
SYRSRSAFKL
10
LEVNERHQIL
20
RPGLRVLDCG
30
AAPGAWSQVA
40
VQKVNAAGTD
50

PSSPVGFVLG
60
VDLLHIFPLE
70
GATFLCPADV
80
TDPRTSQRIL
90
EVLPGRRADV
100

ILSDMAPNAT
110
GFRDLDHDRL
120
ISLCLTLLSV
130
TPDILQPGGT
140
FLCKTWAGSQ
150

SRRLQRRLTE
160
EFQNVRIIKP
170
EVYFLATQYH
188
G
Residue
Distance (Å)
SER4
4.265
SER6
3.468
ALA7
4.765
ASP28
4.851
GLY30
2.900
ALA31
3.510
ALA32
3.067
PRO33
3.067
GLY34
2.997
ALA35
2.915
TRP36
2.866
VAL61
4.397
ASP62
2.660
Residue
Distance (Å)
LEU63
3.482
LEU64
3.668
ALA78
3.415
ASP79
2.899
VAL80
2.892
THR81
4.052
ASP104
2.884
MET105
3.363
ALA106
3.192
PRO107
4.740
LEU123
3.965
LYS144
3.535
References  Top
REF 1 The Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with AdoMet

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