Target Information
| Target General Information | Top | |||||
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| Target ID |
T83979
(Former ID: TTDI02539)
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| Target Name |
Prostacyclin synthase (PTGIS)
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| Synonyms |
Prostaglandin I2 synthase; PTGIS
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| Gene Name |
PTGIS
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Click to Show/Hide
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| BioChemical Class |
Intramolecular oxidoreductases
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| UniProt ID | ||||||
| EC Number |
EC 5.3.99.4
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| Sequence |
MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK
HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR YGFGLMQPEHDVPVRYRIRP Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| ADReCS ID | BADD_A05962 | |||||
| Chemical Structure based Activity Landscape of Target | Top |
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| Target Poor or Non Binders | Top | |||||
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| Target Poor or Non Binders | ||||||
| References | Top | |||||
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| REF 1 | Role of prostacyclin synthase in carcinogenesis. Prostaglandins Other Lipid Mediat. 2017 Nov;133:49-52. | |||||
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