Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83979 | Target Info | |||
| Target Name | Prostacyclin synthase (PTGIS) | ||||
| Synonyms | Prostaglandin I2 synthase; PTGIS | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PTGIS | ||||
| Biochemical Class | Intramolecular oxidoreductases | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Minoxidil | Ligand Info | |||||
| Structure Description | Crystal structure of human prostacyclin synthase in complex with inhibitor minoxidil | PDB:3B6H | ||||
| Method | X-ray diffraction | Resolution | 1.62 Å | Mutation | No | [1] |
| PDB Sequence |
RTRRPGEPPL
32 DLGSIPWLGY42 ALDFGKDAAS52 FLTRMKEKHG62 DIFTILVGGR72 YVTVLLDPHS 82 YDAVVWEPRT92 RLDFHAYAIF102 LMERIFDVQL112 PHYSPSDEKA122 RMKLTLLHRE 132 LQALTEAMYT142 NLHAVLLGDA152 TEAGSGWHEM162 GLLDFSYSFL172 LRAGYLTLYG 182 IEALPRTHES192 QAQDRVHSAD202 VFHTFRQLDR212 LLPKLARGSL222 SVGDKDHMCS 232 VKSRLWKLLS242 PARLARRAHR252 SKWLESYLLH262 LEEMGVSEEM272 QARALVLQLW 282 ATQGNMGPAA292 FWLLLFLLKN302 PEALAAVRGE312 LESILWQLPQ332 KVLDSTPVLD 342 SVLSESLRLT352 AAPFITREVV362 VDLAMPMADG372 REFNLRRGDR382 LLLFPFLSPQ 392 RDPEIYTDPE402 VFKYNRFLNP412 DGSEKKDFYK422 DGKRLKNYNM432 PWGAGHNHCL 442 GRSYAVNSIK452 QFVFLVLVHL462 DLELINADVE472 IPEFDLSRYG482 FGLMQPEHDV 492 PVRYRIRPH
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| Ligand Name: B-Octylglucoside | Ligand Info | |||||
| Structure Description | Crystal structure of human prostacyclin synthase in complex with inhibitor minoxidil | PDB:3B6H | ||||
| Method | X-ray diffraction | Resolution | 1.62 Å | Mutation | No | [1] |
| PDB Sequence |
RTRRPGEPPL
32 DLGSIPWLGY42 ALDFGKDAAS52 FLTRMKEKHG62 DIFTILVGGR72 YVTVLLDPHS 82 YDAVVWEPRT92 RLDFHAYAIF102 LMERIFDVQL112 PHYSPSDEKA122 RMKLTLLHRE 132 LQALTEAMYT142 NLHAVLLGDA152 TEAGSGWHEM162 GLLDFSYSFL172 LRAGYLTLYG 182 IEALPRTHES192 QAQDRVHSAD202 VFHTFRQLDR212 LLPKLARGSL222 SVGDKDHMCS 232 VKSRLWKLLS242 PARLARRAHR252 SKWLESYLLH262 LEEMGVSEEM272 QARALVLQLW 282 ATQGNMGPAA292 FWLLLFLLKN302 PEALAAVRGE312 LESILWQLPQ332 KVLDSTPVLD 342 SVLSESLRLT352 AAPFITREVV362 VDLAMPMADG372 REFNLRRGDR382 LLLFPFLSPQ 392 RDPEIYTDPE402 VFKYNRFLNP412 DGSEKKDFYK422 DGKRLKNYNM432 PWGAGHNHCL 442 GRSYAVNSIK452 QFVFLVLVHL462 DLELINADVE472 IPEFDLSRYG482 FGLMQPEHDV 492 PVRYRIRPH
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change. J Biol Chem. 2008 Feb 1;283(5):2917-26. | ||||
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