Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83979 | Target Info | |||
| Target Name | Prostacyclin synthase (PTGIS) | ||||
| Synonyms |
Prostaglandin I2 synthase; PTGIS
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | PTGIS | ||||
| Biochemical Class | Intramolecular oxidoreductases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 39 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dazoxiben
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|
Terminated | Compound Info | ||
| Synonyms |
DAZOXIBEN; 78218-09-4; Dazoxibene; Dazoxiben [INN-Spanish]; Dazoxibenum; Dazoxibenum [INN-Latin]; Dazoxibene [INN-French]; Dazoxiben [INN:BAN]; 4-(2-(1H-Imidazol-1-yl)ethoxy)benzoic acid; UNII-09ZFC7974Q; 4-(2-imidazol-1-ylethoxy)benzoic acid; UK 37248; Benzoic acid, 4-(2-(1H-imidazol-1-yl)ethoxy)-; p-(2-Imidazol-1-ylethoxy)benzoic acid; 4-(2-(1-Imidazolyl)ethoxy)benzoesaeure; UK-37248; CHEMBL267473; 103735-00-8; 4-[2-(1H-imidazol-1-yl)ethoxy]benzoic acid; 09ZFC7974Q; AH-P 719 (9CI); NCGC00018938-03
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
CGS-13080
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Terminated | Compound Info | ||
| Synonyms |
PIRMAGREL; CGS-13080; Pirmagrelum [Latin]; Pirmgrel; Pirmagrel [USAN:INN]; UNII-9J5H2VA91V; CGS 13080; 85691-74-3; CHEMBL48092; 9J5H2VA91V; Imidazo(1,5-a)pyridine-5-hexanoic acid; Pirmagrelum; Imidazo[1,5-a]pyridine-5-hexanoic acid; Pirmagrel (USAN/INN); AC1L1IZ7; SCHEMBL636018; DTXSID80234982; LIFOFTJHFFTNRV-UHFFFAOYSA-N; ZINC2021333; BDBM50025953; imidazol(1,5-a)pyridine-5-hexanoic acid; LS-177888; 6-imidazo[1,5-a]pyridin-5-ylhexanoic acid; 5-(5-carboxypentyl)imidazo[1,5-a]pyridine; 5-(5-carboxypentyl)-imidazo[1,5-a]pyridine
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
3-Imidazol-1-ylmethyl-2-isopropyl-1H-indole
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Investigative | Compound Info | ||
| Synonyms |
72818-36-1; UK 34787; UK-34787; CHEMBL284356; 3-(1h-imidazol-1-ylmethyl)-2-(propan-2-yl)-1h-indole; 3-(imidazol-1-ylmethyl)-2-propan-2-yl-1H-indole; 3-Isopropyl-3-(1-imidazolylmethyl)indole; AC1L4YBG; 3-Imidazol-1-ylmethyl-2-isopropyl-1H-indole; AC1Q4X5Y; SCHEMBL11346119; CTK5D6874; DTXSID00223136; NZXGMVRYQLENHC-UHFFFAOYSA-N; BDBM50022121; NSC342229; AKOS030539398; NSC-342229; 3-(imidazol-1-ylmethyl)-2-isopropylindole; 3-Imidazol-1-ylmethyl-2-isopropyl-1H-indole(UK-34787); 1H-Indole, 3-(1H-imidazol-1-ylmethyl)-2-(1-methylethy
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(2-Imidazol-1-yl-ethoxy)-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30395; 4-(2-Imidazol-1-yl-ethoxy)-benzamide; SCHEMBL3005716; DVALIYTWWUIPGC-UHFFFAOYSA-N; BDBM50025995; 75912-57-1; 1-[2-(4-carbamoylphenoxy)ethyl]imidazole; 4-(2-(1H-imidazol-1-yl)ethoxy)benzamide; 1-[2-(4-carbamoyl phenoxy)ethyl]imidazole
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(Z)-6-{2-[1-(2-Methoxy-phenoxy)-1-methyl-ethyl]-4-pyridin-3-yl-[1,3]dioxan-5-yl}-hex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162032; SCHEMBL9765884; BDBM50036369
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|
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| Activity |
IC50 = 51000 nM
|
[4] | |||
| Compound Name |
(Z)-6-{2-[1-(2-Cyano-6-methyl-phenoxy)-1-methyl-ethyl]-4-pyridin-3-yl-[1,3]dioxan-5-yl}-hex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158687; BDBM50036373
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|
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| Activity |
IC50 = 60000 nM
|
[4] | |||
| Compound Name |
2-{1-[5-((Z)-5-Carboxy-pent-2-enyl)-4-pyridin-3-yl-[1,3]dioxan-2-yl]-1-methyl-ethoxy}-benzoic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL159344; BDBM50036350
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|
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| Activity |
IC50 = 73000 nM
|
[4] | |||
| Compound Name |
(Z)-6-[2-(1-Methyl-1-phenoxy-ethyl)-4-pyridin-3-yl-[1,3]dioxan-5-yl]-hex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL159196; SCHEMBL9161390; BDBM50036371; L003173
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|
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| Activity |
IC50 = 75000 nM
|
[4] | |||
| Compound Name |
Dazmegrel
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|
Investigative | Compound Info | ||
| Synonyms |
UNII-31340R8PVU; UK-38485; UK-38,485; 3-(Imidazol-1-ylmethyl)-2-methylindole-1-propionic acid; CHEMBL283656; 31340R8PVU; NCGC00160660-01; DSSTox_CID_26281; DSSTox_RID_81507; DSSTox_GSID_46281; Dazmegrelum [Latin]; Dazmegrelum; UK 38,485; Dazmegrel [USAN:INN:BAN]; Dazmegrel (USAN/INN); 1H-Indole-1-propanoic acid, 3-(1H-imidazol-1-ylmethyl)-2-methyl-; Oprea1_040141; CBDivE_000516; SCHEMBL154037; DTXSID9046281; CTK2H7526; 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-Indole-1-propanoic acid; Tox21_111966; BDBM50000317; CCG-20521; STK094650; ZINC35877948; AKOS005395464; Tox21_111966_1; MCULE-1200400346; NCGC00160660-02; DA-02947; EU-0045204; FT-0746556; ST50898364; D03661; SR-01000082437; SR-01000082437-1; Q27256003; 3-[3-(imidazolylmethyl)-2-methylindolyl]propanoic acid; 3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-propionic acid; 1H-Indole-1-propanoicacid, 3-(1H-imidazol-1-ylmethyl)-2-methyl-; 3-[3-(1H-imidazol-3-ium-3-ylmethyl)-2-methylindol-1-yl]propanoate; 3-[3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indol-1-yl]propanoic acid
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3-Imidazol-1-ylmethyl-indol-1-yl)-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL117851; SCHEMBL11382938; BDBM50022126; 2-[3-(imidazol-1-ylmethyl)indol-1-yl]acetic acid
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(2-Imidazol-1-yl-ethoxy)-N,N-dimethyl-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL286092; SCHEMBL10750950; BDBM50025985
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(2-Imidazol-1-yl-ethoxy)-benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33407; BDBM50026000
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(2-Imidazol-1-yl-ethoxy)-N-methyl-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL286308; SCHEMBL10751448; BDBM50025992; ZINC29218994; 4-(2-imidazol-1-ylethoxy)-N-methylbenzamide
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(3-Imidazol-1-ylmethyl-5-methoxy-indol-1-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419943; BDBM50022122
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(5-Chloro-3-imidazol-1-ylmethyl-indol-1-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL331822; BDBM50022119
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(Z)-6-{2-[1-(4-Methoxy-phenoxy)-1-methyl-ethyl]-4-pyridin-3-yl-[1,3]dioxan-5-yl}-hex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352075; SCHEMBL9765876; BDBM50036381
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Imidazol-1-ylmethyl-3-methyl-benzo[b]thiophene-6-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47164; SCHEMBL10855281; BDBM50022219
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-(5-Bromo-3-imidazol-1-ylmethyl-indol-1-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL117459; SCHEMBL11376944; BDBM50022129; 3-[5-bromo-3-(imidazol-1-ylmethyl)indol-1-yl]propanoic acid
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(3-Imidazol-1-ylmethyl-6-trifluoromethyl-indol-1-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116980; BDBM50022131
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-Imidazol-1-ylmethyl-benzo[b]thiophene-5-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46912; BDBM50022217
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(Z)-6-{2-[1-Methyl-1-(2-methylsulfanyl-phenoxy)-ethyl]-4-pyridin-3-yl-[1,3]dioxan-5-yl}-hex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352196; BDBM50036353
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(Z)-6-{2-[1-(2-Hydroxy-phenoxy)-1-methyl-ethyl]-4-pyridin-3-yl-[1,3]dioxan-5-yl}-hex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348968; SCHEMBL9765888; BDBM50036385; L003850
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Imidazol-1-ylmethyl-3-methyl-benzo[b]thiophene-5-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43141; SCHEMBL149467; BDBM50022216
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-(2-Cyclopropyl-3-imidazol-1-ylmethyl-indol-1-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL114723; SCHEMBL11384505; BDBM50022130
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(2-Imidazol-1-yl-ethoxy)-benzoic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33747; SCHEMBL10751882; BDBM50025991; ethyl 2-(2-imidazol-1-ylethoxy)benzoate
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Chloro-2-imidazol-1-ylmethyl-benzofuran-5-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557333; SCHEMBL10851831; BDBM50022223
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Isbogrel
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Investigative | Compound Info | ||
| Synonyms |
Cv-4151; UNII-HGB7P08R36; (E)-7-Phenyl-7-(pyridin-3-yl)hept-6-enoic acid; (E)-7-phenyl-7-pyridin-3-ylhept-6-enoic acid; CHEMBL26820; HGB7P08R36; (E)-7-Phenyl-7-(3-pyridyl)-6-heptenoic acid; NCGC00160351-01; Isbogrel [INN]; Isbogrelum; Isbogrelum [INN-Latin]; CCRIS 7236; CV 4151; BRN 4257992; (E)-7-Phenyl-7-(3-pyridinyl)-6-heptenoic acid; 7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid; DSSTox_CID_1133; SCHEMBL4060; DSSTox_RID_75964; (6E)-7-phenyl-7-pyridin-3-ylhept-6-enoic acid; A-66900; DSSTox_GSID_21133; 6-Heptenoic acid, 7-phenyl-7-(3-pyridinyl)-, (E)-; DTXSID4021133; Tox21_111756; BDBM50010960; ZINC13437583; AKOS000276942; (E)-7-(3-pyridyl)-7-phenyl-6-heptenoic acid; (E)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid; Q27279917; 7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid(CV-4151)
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-(5-Dimethylamino-3-imidazol-1-ylmethyl-indol-1-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL117652; BDBM50022125
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[3-(Imidazol-1-ylmethyl)indol-1-yl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269619; SCHEMBL11384938; BDBM50022124
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(3-Imidazol-1-ylmethyl-2-isopropyl-indol-1-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL114672; BDBM50022118
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(Z)-6-[2-(2-Cyano-phenyl)-4-pyridin-3-yl-[1,3]dioxan-5-yl]-hex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL161104; BDBM50036358
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[2-(2-Imidazol-1-yl-ethoxy)-phenyl]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL284963; SCHEMBL6368272; BDBM50025993; AKOS019308922; 2-[2-(2-imidazol-1-ylethoxy)phenyl]acetic acid
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
[4-(2-Imidazol-1-yl-ethoxy)-phenoxy]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL34041; BDBM50025983
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(3-Imidazol-1-ylmethyl-5-methyl-indol-1-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL326710; BDBM50022127
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(3',4'-Dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
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|
Investigative | Compound Info | ||
| Synonyms |
pf-9184; CHEMBL1087267; C21H14Cl2N2O4S; AOB4734; SYN5102; BDBM50313205; AKOS027470312; ZINC101331153; PF 9184; NCGC00402263-03; AS-16466; HY-19622; CS-0015995; FT-0699578
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-Chloro-2-imidazol-1-ylmethyl-benzo[b]thiophene-6-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47165; SCHEMBL10861539; BDBM50022227
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-acrylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115844; BDBM50022123
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(Z)-6-[2-(4-Cyano-phenyl)-4-pyridin-3-yl-[1,3]dioxan-5-yl]-hex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL159699; SCHEMBL9723970; BDBM50036364; L003174
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(Z)-6-{2-[1-(2-Cyano-5-methyl-phenoxy)-1-methyl-ethyl]-4-pyridin-3-yl-[1,3]dioxan-5-yl}-hex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL350816; BDBM50036378
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Imidazol-1-ylmethyl-1H-indole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116794; 3-Imidazol-1-ylmethyl-1H-indole; 1H-Indole, 3-(1H-imidazol-1-ylmethyl)-; 19714-15-9; MLS000105265; AC1LGCIB; Cambridge id 5261471; CBDivE_013805; SCHEMBL9214699; 3-(imidazol-1-ylmethyl)indole; CTK0E0809; DTXSID40355147; FRADTKAUXQUOIJ-UHFFFAOYSA-N; MolPort-001-788-875; HMS2390H20; ZINC293947; 3-(imidazol-1-ylmethyl)-1H-indole; BDBM50022120; AKOS030489795; MCULE-1147695503; 3-(1H-imidazol-1-ylmethyl)-1H-Indole; BAS 01027138; 1-(1H-Indole-3-ylmethyl)-1H-imidazole
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| Activity |
IC50 = 650000 nM
|
[3] | |||
| Compound Name |
1-(2-Phenoxy-ethyl)-1H-imidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL284827; 1-(2-Phenoxy-ethyl)-1H-imidazole; 1H-Imidazole, 1-(2-phenoxyethyl)-; 1-(2-Phenoxyethyl)imidazole; SCHEMBL10370478; INUSBZKZIYQSRM-UHFFFAOYSA-N; ZINC26473891; BDBM50025988; AKOS002677376
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
N-[4-(2-Imidazol-1-yl-ethoxy)-phenyl]-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33690; SCHEMBL10928050; BDBM50025987; ZINC29218594; N-[4-(2-imidazol-1-ylethoxy)phenyl]acetamide
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|
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2H-Tetrazole, 5-[4-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL33632; SCHEMBL10750806; BDBM50025999; 5-[4-(2-imidazol-1-ylethoxy)phenyl]-2H-tetrazole; 5-[4-(2-Imidazol-1-yl-ethoxy)-phenyl]-1H-tetrazole
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
[4-(2-Imidazol-1-yl-ethoxy)-phenyl]-acetic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL34574; BDBM50025994
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|
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
Imidazole
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|
Investigative | Compound Info | ||
| Synonyms |
1H-Imidazole; Glyoxaline; Imidazol; Iminazole; Miazole; 1,3-Diazole; Glyoxalin; Imutex; 1,3-Diaza-2,4-cyclopentadiene; Pyrro(b)monazole; USAF EK-4733; Pyrro[b]monazole; Formamidine, N,N'-vinylene-; Glioksal [Polish]; Glioksal; Methanimidamide, N,N'-1,2-ethenediyl-; CCRIS 3345; AI3-24703; UNII-7GBN705NH1; NSC 60522; BRN 0103853; N,N'-vinyleneformamidine; MFCD00005183; CHEMBL540; 7GBN705NH1; DTXSID2029616; N,N'-1,2-ethenediylmethanimidamide; Imidazole, 99%; Imidazole, ACS reagent; DSSTox_CID_9616; DSSTox_RID_78788; DSSTox_GSID_29616; Imidazole, 99+%, crystalline; 1H-imidazol; Imidazole (8CI); NSC51860; Imidazole, puriss. p.a., >=99.5% (GC); EINECS 206-019-2; NSC 51860; Immidazole; imidazole-; 1-H-imidazole; Imidazole, Reagent; {Pyrro[b]monazole}; 1,4-cyclopentadiene; Imidazole, ACS grade; ACMC-1CPAG; 1H-Imidazole (9CI); Formamidine,N'-vinylene-; bmse000096; bmse000790; WLN: T5M CNJ; EC 206-019-2; NCIStruc1_001975; NCIStruc2_000693; Imidazole, LR, >=99%; 5-23-04-00191 (Beilstein Handbook Reference); KSC203M9T; MLS001055465; BDBM7882; Imidazole-buffered saline (5X); CTK1A3699; HSDB 8449; 1,3-Diaza-2,4-cyclopentadiene-; Imidazole, ReagentPlus(R), 99%; ZINC901039; Imidazole, for synthesis, 99.5%; BCP26547; HY-D0837; KS-000002NA; NSC60522; Methanimidamide,N'-1,2-ethenediyl-; Tox21_201504; Tox21_303345; ANW-26483; BBL009685; NSC-60522; s6006; SBB040815; STK362967; AKOS000120177; AM82000; CS-5135; DB03366; MCULE-1410806694; Imidazole, BioUltra, >=99.5% (GC); NCGC00090984-01; NCGC00090984-02; NCGC00257344-01; NCGC00259055-01; 2,4-Diazonia-2,4-cyclopentadiene-1-ide; AK-76381; BP-11451; SC-18719; SMR000057825; ST097249; 1,3-Diaza-2,4-cyclopentadiene;Glyoxaline; Imidazole, SAJ special grade, >=99.0%; Imidazole, Vetec(TM) reagent grade, 98%; DB-002018; Imidazole, 0.5M buffer solution, pH 6.0; Imidazole, 0.5M buffer solution, pH 7.0; Imidazole, 0.5M buffer solution, pH 7.5; FT-0627179; FT-0670295; I0001; I0014; I0288; I0290; Imidazole, >=99% (titration), crystalline; Imidazole Zone Refined (number of passes:30); Imidazole, ACS reagent, >=99% (titration); 2519-EP0930075A1; 2519-EP1441224A2; 2519-EP2269977A2; 2519-EP2269978A2; 2519-EP2269985A2; 2519-EP2269990A1; 2519-EP2269991A2; 2519-EP2269992A1; 2519-EP2270002A1; 2519-EP2270006A1; 2519-EP2270008A1; 2519-EP2270010A1; 2519-EP2270011A1; 2519-EP2270014A1; 2519-EP2270015A1; 2519-EP2270113A1; 2519-EP2270505A1; 2519-EP2272509A1; 2519-EP2272510A1; 2519-EP2272516A2; 2519-EP2272517A1; 2519-EP2272537A2; 2519-EP2272813A2; 2519-EP2272817A1; 2519-EP2272825A2; 2519-EP2272827A1; 2519-EP2272828A1; 2519-EP2272832A1; 2519-EP2272838A1; 2519-EP2272839A1; 2519-EP2272840A1; 2519-EP2272841A1; 2519-EP2272848A1; 2519-EP2272849A1; 2519-EP2272935A1; 2519-EP2272972A1; 2519-EP2272973A1; 2519-EP2274983A1; 2519-EP2275102A1; 2519-EP2275395A2; 2519-EP2275401A1; 2519-EP2275404A1; 2519-EP2275409A1; 2519-EP2275411A2; 2519-EP2275412A1; 2519-EP2275413A1; 2519-EP2275414A1; 2519-EP2276085A1; 2519-EP2277848A1; 2519-EP2277858A1; 2519-EP2277872A1; 2519-EP2277880A1; 2519-EP2280000A1; 2519-EP2280005A1; 2519-EP2280009A1; 2519-EP2281563A1; 2519-EP2281813A1; 2519-EP2281815A1; 2519-EP2281818A1; 2519-EP2281819A1; 2519-EP2281824A1; 2519-EP2284149A1; 2519-EP2284150A2; 2519-EP2284151A2; 2519-EP2284152A2; 2519-EP2284153A2; 2519-EP2284155A2; 2519-EP2284156A2; 2519-EP2284157A1; 2519-EP2284164A2; 2519-EP2284169A1; 2519-EP2284920A1; 2519-EP2286812A1; 2519-EP2286915A2; 2519-EP2287140A2; 2519-EP2287148A2; 2519-EP2287150A2; 2519-EP2287161A1; 2519-EP2287162A1; 2519-EP2287165A2; 2519-EP2287166A2; 2519-EP2287167A1; 2519-EP2289868A1; 2519-EP2289871A1; 2519-EP2289884A1; 2519-EP2289890A1; 2519-EP2289894A2; 2519-EP2292586A2; 2519-EP2292590A2; 2519-EP2292592A1; 2519-EP2292593A2; 2519-EP2292596A2; 2519-EP2292597A1; 2519-EP2292604A2; 2519-EP2292606A1; 2519-EP2292610A1; 2519-EP2292611A1; 2519-EP2292612A2; 2519-EP2292613A1; 2519-EP2292617A1; 2519-EP2292619A1; 2519-EP2292620A2; 2519-EP2292621A1; 2519-EP2292630A1; 2519-EP2295401A2; 2519-EP2295402A2; 2519-EP2295406A1; 2519-EP2295414A1; 2519-EP2295415A1; 2519-EP2295419A2; 2519-EP2295421A1; 2519-EP2295426A1; 2519-EP2295427A1; 2519-EP2295429A1; 2519-EP2295432A1; 2519-EP2295433A2; 2519-EP2295434A2; 2519-EP2295550A2; 2519-EP2298731A1; 2519-EP2298732A1; 2519-EP2298742A1; 2519-EP2298743A1; 2519-EP2298744A2; 2519-EP2298755A1; 2519-EP2298763A1; 2519-EP2298766A1; 2519-EP2298767A1; 2519-EP2298770A1; 2519-EP2298772A1; 2519-EP2298774A1; 2519-EP2298776A1; 2519-EP2298778A1; 2519-EP2298783A1; 2519-EP2298828A1; 2519-EP2299509A1; 2519-EP2300438A1; 2519-EP2301534A1; 2519-EP2301536A1; 2519-EP2301538A1; 2519-EP2301912A2; 2519-EP2301913A1; 2519-EP2301914A1; 2519-EP2301916A2; 2519-EP2301918A1; 2519-EP2301921A1; 2519-EP2301926A1; 2519-EP2301929A1; 2519-EP2301930A1; 2519-EP2301931A1; 2519-EP2301932A1; 2519-EP2301933A1; 2519-EP2301934A1; 2519-EP2301935A1; 2519-EP2301937A1; 2519-EP2301940A1; 2519-EP2301983A1; 2519-EP2302003A1; 2519-EP2302015A1; 2519-EP2305219A1; 2519-EP2305250A1; 2519-EP2305637A2; 2519-EP2305640A2; 2519-EP2305643A1; 2519-EP2305648A1; 2519-EP2305651A1; 2519-EP2305652A2; 2519-EP2305657A2; 2519-EP2305658A1; 2519-EP2305659A1; 2519-EP2305668A1; 2519-EP2305674A1; 2519-EP2305676A1; 2519-EP2305682A1; 2519-EP2305689A1; 2519-EP2305695A2; 2519-EP2305696A2; 2519-EP2305697A2; 2519-EP2305698A2; 2519-EP2305769A2; 2519-EP2305808A1; 2519-EP2308510A1; 2519-EP2308562A2; 2519-EP2308812A2; 2519-EP2308832A1; 2519-EP2308833A2; 2519-EP2308839A1; 2519-EP2308840A1; 2519-EP2308848A1; 2519-EP2308852A1; 2519-EP2308854A1; 2519-EP2308855A1; 2519-EP2308861A1; 2519-EP2308863A1; 2519-EP2308867A2; 2519-EP2308868A1; 2519-EP2308869A1; 2519-EP2308870A2; 2519-EP2308872A1; 2519-EP2308873A1; 2519-EP2308874A1; 2519-EP2308877A1; 2519-EP2308879A1; 2519-EP2308880A1; 2519-EP2308883A1; 2519-EP2309584A1; 2519-EP2311451A1; 2519-EP2311455A1; 2519-EP2311464A1; 2519-EP2311796A1; 2519-EP2311797A1; 2519-EP2311798A1; 2519-EP2311799A1; 2519-EP2311802A1; 2519-EP2311803A1; 2519-EP2311815A1; 2519-EP2311818A1; 2519-EP2311820A1; 2519-EP2311823A1; 2519-EP2311825A1; 2519-EP2311826A2; 2519-EP2311827A1; 2519-EP2311830A1; 2519-EP2311841A1; 2519-EP2311842A2; 2519-EP2314295A1; 2519-EP2314558A1; 2519-EP2314574A1; 2519-EP2314575A1; 2519-EP2314582A1; 2519-EP2314583A1; 2519-EP2314587A1; 2519-EP2315303A1; 2519-EP2315502A1; 2519-EP2316450A1; 2519-EP2316452A1; 2519-EP2316459A1; 2519-EP2316470A2; 2519-EP2316829A1; 2519-EP2316831A1; 2519-EP2316832A1; 2519-EP2316833A1; 2519-EP2316836A1; 2519-EP2316905A1; 2519-EP2316906A2; 2519-EP2371810A1; 2519-EP2371811A2; 2519-EP2371812A1; 2519-EP2371831A1; 2519-EP2372017A1; 2519-EP2372804A1; 2519-EP2377847A1; 2519-EP2377848A1; 2519-EP2378585A1; 2519-EP2380874A2; C01589; M-6056; 59390-EP2270011A1; 59390-EP2272846A1; 59390-EP2305808A1; 59390-EP2308852A1; 59390-EP2371806A1; 59390-EP2371812A1; 142240-EP2270010A1; 142240-EP2292593A2; Imidazole buffer Solution, BioUltra, 1 M in H2O; Q328692; J-200340; F2190-0638; Z1245636370; 4286D518-643C-4C69-BCE7-519D073F4992
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| Activity |
IC50 = 4000000 nM
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| References | Top | ||||
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| REF 1 | Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles. J Med Chem. 1985 Oct;28(10):1427-32. | ||||
| REF 2 | Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors. J Med Chem. 1985 Feb;28(2):164-70. | ||||
| REF 3 | Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. J Med Chem. 1986 Mar;29(3):342-6. | ||||
| REF 4 | Dual-acting thromboxane receptor antagonist/synthase inhibitors: synthesis and biological properties of [2-substituted-4-(3-pyridyl)-1,3-dioxan-5-yl] alkenoic acids. J Med Chem. 1995 Feb 17;38(4):686-94. | ||||
| REF 5 | Selective thromboxane synthetase inhibitors. 4. 2-(1H-imidazol-1-ylmethyl) carboxylic acids of benzo[b]furan, benzo[b]thiophene, indole, and naphthalene. J Med Chem. 1986 Sep;29(9):1643-50. | ||||
| REF 6 | Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1604-9. | ||||
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