Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
Drug Property Profile of Target
Target Poor or Non Binders
Target Regulators
References
Drug Binding Sites of Target  Top
Ligand Name: AMP-PNP Ligand Info
Structure Description Crystal structure of LIMK1 D460N mutant in complex with AMP-PNP PDB:5HVJ
Method X-ray diffraction Resolution 2.20 Å Mutation Yes [4]
PDB Sequence
RPHRIFRPSD
338
LIHGEVLGKG
348
CFGQAIKVTH
358
RETGEVMVMK
368
ELIRFDEETQ
378

RTFLKEVKVM
388
RCLEHPNVLK
398
FIGVLYKDKR
408
LNFITEYIKG
418
GTLRGIIKSM
428

DSQYPWSQRV
438
SFAKDIASGM
448
AYLHSMNIIH
458
RNLNSHNCLV
468
RENKNVVVAD
478

FGLARLMTVV
510
GNPYWMAPEM
520
INGRSYDEKV
530
DVFSFGIVLC
540
EIIGRVNADP
550

DYLPRTMDFG
560
LNVRGFLDRY
570
CPPNCPPSFF
580
PITVRCCDLD
590
PEKRPSFVKL
600

EHWLETLRMH
610
LAGHLPLGPQ
620
LEQLDRGFWE
630
TYR
Residue
Distance (Å)
LEU345
3.878
GLY346
3.719
ALA353
3.753
VAL366
4.036
LYS368
4.852
LEU397
4.013
THR413
4.393
Residue
Distance (Å)
GLU414
3.256
TYR415
4.204
ILE416
3.396
THR420
3.430
HIS464
4.252
LEU467
3.607
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: L-serine-O-phosphate Ligand Info
Structure Description Crystal structure of LIMK1 mutant D460N in complex with full-length cofilin-1 PDB:5HVK
Method X-ray diffraction Resolution 3.50 Å Mutation Yes [4]
PDB Sequence
GAMGSRPHRI
333
FRPSDLIHGE
343
VLGKGCFGQA
353
IKVTHRETGE
363
VMVMKELIRF
373

DEETQRTFLK
383
EVKVMRCLEH
393
PNVLKFIGVL
403
YKDKRLNFIT
413
EYIKGGTLRG
423

IIKSMDSQYP
433
WSQRVSFAKD
443
IASGMAYLHS
453
MNIIHRNLNS
463
HNCLVRENKN
473

VVVADFGLAR
483
LMVDPDRKKR
506
YVVGNPYWMA
517
PEMINGRSYD
527
EKVDVFSFGI
537

VLCEIIGRVN
547
ADPDYLPRTM
557
DFGLNVRGFL
567
DRYCPPNCPP
577
SFFPITVRCC
587

DLDPEKRPSF
597
VKLEHWLETL
607
RMHLAGHLPL
617
GPQLEQLDRG
627
FWETYRR
Residue
Distance (Å)
CYS349
3.672
THR380
4.540
ASN460
3.693
ASN462
4.975
ASP478
3.998
Residue
Distance (Å)
LEU481
3.013
VAL510
4.764
GLY511
4.203
ASN512
3.469
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
Protein Name Pfam ID Percentage of Identity (%) E value
PAK-2 protein kinase (PAK2)
PF00786 ; 
PF00069
28.114 (79/281) 3.42E-29
Serine/threonine-protein kinase 25 (STK25)
PF00069
28.720 (83/289) 7.69E-28
MST-1 protein kinase (STK4)
PF11629 ; 
PF00069
27.365 (81/296) 7.91E-28
Serine/threonine-protein kinase 26 (STK26)
PF00069
29.167 (84/288) 2.01E-27
Serine/threonine-protein kinase 3 (STK3)
PF11629 ; 
PF00069
27.907 (84/301) 4.05E-27
PAK-1 protein kinase (PAK1)
PF00786 ; 
PF00069
27.402 (77/281) 4.20E-27
Serine/threonine-protein kinase 10 (STK10)
PF00069 ; 
PF12474
29.818 (82/275) 1.24E-26
Serine/threonine-protein kinase 24 (STK24)
PF00069
29.434 (78/265) 1.52E-26
Serine/threonine-protein kinase PAK 3 (PAK3)
PF00786 ; 
PF00069
27.046 (76/281) 3.20E-26
Fused homolog (STK36)
PF13646 ; 
PF00069
27.972 (80/286) 6.51E-25
STE20-related serine/threonine-protein kinase (SLK)
PF00069 ; 
PF12474
30.275 (66/218) 2.93E-24
Mixed lineage kinase 1 (MAP3K9)
PF00069 ; 
PF14604
29.965 (86/287) 3.13E-24
MAPK/ERK kinase kinase 3 (MAP3K3)
PF00564 ; 
PF00069
29.630 (64/216) 3.64E-24
Cyclin-dependent kinase 3 (CDK3)
PF00069
28.502 (59/207) 1.43E-23
Cyclin-dependent kinase 2 (CDK2)
PF00069
28.986 (60/207) 2.34E-23
SIK family kinase 3 (SIK3)
PF00069
30.049 (61/203) 3.10E-23
Serine/threonine-protein kinase Nek9 (NEK9)
PF00069 ; 
PF00415
27.612 (74/268) 1.03E-22
Omphalocele kinase 1 (NUAK1)
PF00069
27.935 (69/247) 1.42E-22
Aurora kinase A (AURKA)
PF00069
28.230 (59/209) 2.43E-22
Serine/threonine-protein kinase Nek8 (NEK8)
PF00069 ; 
PF00415
25.887 (73/282) 2.89E-22
MAP/microtubule affinity-regulating kinase 4 (MARK4)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 29.032 (72/248) 3.63E-22
BR serine/threonine kinase 1 (BRSK1)
PF00069
28.517 (75/263) 4.04E-22
MAPK/ERK kinase kinase 2 (MAP3K2)
PF00564 ; 
PF00069
27.778 (60/216) 4.56E-22
Serine/threonine-protein kinase MARK2 (MARK2)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 27.600 (69/250) 5.37E-22
Protein kinase C theta (PRKCQ)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 27.778 (60/216) 8.28E-22
Serine/threonine-protein kinase PAK 5 (PAK5)
PF00786 ; 
PF00069
25.614 (73/285) 1.88E-21
Doublecortin-like kinase 3 (DCLK3)
PF00069
27.305 (77/282) 2.14E-21
Oxidative stress responsive 1 (OXSR1)
PF12202 ; 
PF00069
28.333 (68/240) 2.51E-21
MAPK/ERK kinase kinase 1 (MAP3K1)
PF00069
23.985 (65/271) 2.55E-21
NIMA-related kinase 6 (NEK6)
PF00069
26.471 (54/204) 4.08E-21
Serine/threonine-protein kinase MARK1 (MARK1)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 28.922 (59/204) 5.19E-21
Serine/threonine-protein kinase PAK 6 (PAK6)
PF00786 ; 
PF00069
26.794 (56/209) 5.38E-21
BR serine/threonine kinase 2 (BRSK2)
PF00069
29.694 (68/229) 5.51E-21
Microtubule affinity regulating kinase 3 (MARK3)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 29.412 (60/204) 6.67E-21
Ste-20-related kinase (STK39)
PF12202 ; 
PF00069
29.167 (70/240) 8.80E-21
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
PF16579 ; 
PF00069
27.839 (76/273) 8.90E-21
PAK-4 protein kinase (PAK4)
PF00786 ; 
PF00069
26.316 (55/209) 9.10E-21
RAC-gamma serine/threonine-protein kinase (AKT3)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 28.512 (69/242) 9.18E-21
Serine/threonine-protein kinase Nek3 (NEK3)
PF00069
28.713 (58/202) 1.27E-20
Cyclin-dependent kinase 1 (CDK1)
PF00069
30.841 (66/214) 1.28E-20
NIMA-related kinase 7 (NEK7)
PF00069
25.573 (67/262) 1.52E-20
SPS1/STE20-related protein kinase YSK4 (YSK4)
PF00069
28.169 (60/213) 1.55E-20
Serine/threonine-protein kinase Nek5 (NEK5)
PF00069
27.488 (58/211) 2.95E-20
Serine/threonine-protein kinase Sgk2 (SGK2)
PF00069 ; 
PF00433
27.197 (65/239) 3.11E-20
Aurora kinase C (AURKC)
PF00069
28.302 (60/212) 3.15E-20
Serine/threonine-protein kinase Nek4 (NEK4)
PF00069
25.940 (69/266) 3.77E-20
Myosin-IIIb (MYO3B)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 29.210 (85/291) 5.09E-20
Serine/threonine-protein kinase 33 (STK33)
PF00069
27.273 (57/209) 5.46E-20
Serine/threonine-protein kinase Sgk3 (SGK3)
PF00069 ; 
PF00433 ; 
PF00787
More >>
 27.731 (66/238) 5.50E-20
TAO kinase 3 (TAOK3)
PF00069
28.929 (81/280) 5.91E-20
TRAF2 and NCK interacting kinase (TNIK)
PF00780 ; 
PF00069
28.241 (61/216) 6.25E-20
MEK kinase kinase 1 (MAP4K1)
PF00780 ; 
PF00069
25.468 (68/267) 6.30E-20
Myosin-IIIa (MYO3A)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 26.756 (80/299) 8.30E-20
Serine/threonine-protein kinase ULK1 (ULK1)
PF12063 ; 
PF00069
29.245 (62/212) 8.92E-20
Misshapen-like kinase 1 (MINK1)
PF00780 ; 
PF00069
27.442 (59/215) 1.01E-19
Serine/threonine-protein kinase D3 (PRKD3)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 25.231 (82/325) 1.14E-19
Serine/threonine-protein kinase TAO2 (TAOK2)
PF00069
29.279 (65/222) 1.38E-19
Unc-51 like kinase 3 (ULK3)
PF04212 ; 
PF00069
26.531 (78/294) 1.43E-19
NIMA-related kinase 1 (NEK1)
PF00069
27.053 (56/207) 1.64E-19
Putative 3-phosphoinositide-dependent protein kinase 2 (PDPK2P)
PF00069
25.279 (68/269) 1.75E-19
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
PF16579 ; 
PF00069
27.076 (75/277) 2.21E-19
NUAK family SNF1-like kinase 2 (NUAK2)
PF00069
25.483 (66/259) 2.37E-19
RAC-beta serine/threonine-protein kinase (AKT2)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 26.587 (67/252) 2.62E-19
Serine/threonine-protein kinase Sgk1 (SGK1)
PF00069 ; 
PF00433
27.660 (65/235) 2.81E-19
NIMA-related kinase 2 (NEK2)
PF00069
28.910 (61/211) 2.84E-19
Cyclin-dependent kinase-like 5 (CDKL5)
PF00069
25.373 (51/201) 3.79E-19
Phosphoinositide dependent protein kinase-1 (PDPK1)
PF14593 ; 
PF00069
25.279 (68/269) 4.08E-19
Putative serine/threonine-protein kinase SIK1B (SIK1B)
PF00069
25.461 (69/271) 4.94E-19
Salt-inducible kinase 1 (SIK1)
PF00069
25.461 (69/271) 5.07E-19
Polo-like kinase 4 (PLK4)
PF00069 ; 
PF18190 ; 
PF18409
More >>
 30.973 (70/226) 5.12E-19
Myosin light kinase (MYLK)
PF16620 ; 
PF00041 ; 
PF07679 ; 
PF00069
More >>
 27.094 (55/203) 8.90E-19
Cyclin-dependent kinase 7 (CDK7)
PF00069
27.632 (63/228) 9.07E-19
Salt-inducible kinase 2 (SIK2)
PF00069
26.568 (72/271) 9.85E-19
Putative serine/threonine-protein kinase PRKY (PRKY)
PF00069
23.305 (55/236) 1.32E-18
MEK kinase kinase 4 (MAP4K4)
PF00780 ; 
PF00069
27.570 (59/214) 1.52E-18
Cyclin-dependent kinase 5 (CDK5)
PF00069
27.094 (55/203) 1.56E-18
Serine/threonine-protein kinase ICK (CILK1)
PF00069
31.343 (63/201) 1.92E-18
Cyclin-dependent kinase 20 (CDK20)
PF00069
27.941 (57/204) 2.18E-18
Ribosomal protein S6 kinase alpha-1 (RSK1)
PF00069 ; 
PF00433
27.570 (59/214) 2.52E-18
Cyclin-dependent kinase 13 (CDK13)
PF12330 ; 
PF00069
27.650 (60/217) 2.60E-18
Cyclin-dependent kinase 12 (CDK12)
PF00069
28.571 (62/217) 2.66E-18
Protein kinase C delta (PRKCD)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 26.540 (56/211) 2.90E-18
Protein kinase D (PRKD1)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 27.723 (56/202) 4.00E-18
Aurora kinase B (AURKB)
PF00069
26.147 (57/218) 4.17E-18
MEK kinase kinase 2 (MAP4K2)
PF00780 ; 
PF00069
27.941 (57/204) 5.03E-18
ERK activator kinase 5 (MAP2K5)
PF00564 ; 
PF00069
28.095 (59/210) 5.04E-18
Doublecortin-like kinase 1 (DCLK1)
PF03607 ; 
PF00069
29.208 (59/202) 5.22E-18
TAO kinase 1 (TAOK1)
PF00069
29.730 (66/222) 5.29E-18
RAC-alpha serine/threonine-protein kinase (AKT1)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 27.869 (68/244) 5.31E-18
cAMP-dependent protein kinase catalytic subunit gamma (PRKACG)
PF00069
25.373 (51/201) 5.89E-18
WNK lysine-deficient protein kinase 3 (WNK3)
PF12202 ; 
PF00069
31.401 (65/207) 6.52E-18
Doublecortin-like kinase 2 (DCLK2)
PF03607 ; 
PF00069
28.713 (58/202) 6.69E-18
Serine/threonine-protein kinase ULK2 (ULK2)
PF12063 ; 
PF00069
28.372 (61/215) 7.11E-18
Serine/threonine-protein kinase D2 (PRKD2)
PF00130 ; 
PF00069
26.733 (54/202) 8.08E-18
MEK kinase kinase 3 (MAP4K3)
PF00780 ; 
PF00069
25.843 (69/267) 1.02E-17
Protein kinase C alpha (PRKCA)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 27.419 (68/248) 1.08E-17
Serine/threonine-protein kinase MAK (MAK)
PF00069
29.851 (60/201) 1.35E-17
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)
PF00069
23.786 (49/206) 1.67E-17
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
PF00069
25.490 (52/204) 1.71E-17
Serine/threonine-protein kinase NIM1 (NIM1K)
PF00069
30.049 (61/203) 2.24E-17
Ribosomal protein S6 kinase alpha-2 (RSK2)
PF00069 ; 
PF00433
26.484 (58/219) 2.33E-17
Serine/threonine-protein kinase PLK3 (PLK3)
PF00069 ; 
PF00659
28.502 (59/207) 2.34E-17
SNF-related serine/threonine-protein kinase (SNRK)
PF00069
25.182 (69/274) 3.08E-17
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
PF00069 ; 
PF12721
28.241 (61/216) 3.13E-17
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 25.820 (63/244) 4.45E-17
Serine/threonine-protein kinase H1 (PSKH1)
PF00069
26.500 (53/200) 4.57E-17
Myosin light chain kinase 3 (MYLK3)
PF00069
28.879 (67/232) 5.08E-17
Serine/threonine-protein kinase Nek11 (NEK11)
PF00069
26.119 (70/268) 5.20E-17
Ribosomal protein S6 kinase alpha-3 (RSK3)
PF00069 ; 
PF00433
26.027 (57/219) 5.35E-17
Cyclin-dependent kinase-like 1 (CDKL1)
PF00069
24.017 (55/229) 5.37E-17
Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G)
PF00069
25.359 (53/209) 5.44E-17
ERK activator kinase 2 (MEK2)
PF00069
24.731 (69/279) 5.57E-17
Cyclin-dependent kinase-like 2 (CDKL2)
PF00069
24.658 (72/292) 6.24E-17
Serine/threonine-protein kinase WNK2 (WNK2)
PF12202 ; 
PF00069
30.918 (64/207) 7.04E-17
Microtubule-associated serine/threonine-protein kinase 1 (MAST1)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 25.620 (62/242) 7.55E-17
Maternal embryonic leucine zipper kinase (MELK)
PF02149 ; 
PF00069
29.588 (79/267) 1.06E-16
Cyclin-dependent kinase-like 3 (CDKL3)
PF00069
27.679 (62/224) 1.16E-16
MAPK/ERK kinase kinase 4 (MAP3K4)
PF19431 ; 
PF00069
24.837 (76/306) 1.22E-16
Cyclin-dependent kinase 9 (CDK9)
PF00069
25.822 (55/213) 1.46E-16
ERK activator kinase 1 (MEK1)
PF00069
25.778 (58/225) 1.48E-16
Hormonally up-regulated neu tumor-associated kinase (HUNK)
PF00069
24.880 (52/209) 2.25E-16
Microtubule-associated serine/threonine-protein kinase 3 (MAST3)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 27.570 (59/214) 2.34E-16
Mitogen-activated protein kinase 15 (MAPK15)
PF00069
28.372 (61/215) 2.55E-16
Polo-like kinase 2 (PLK2)
PF00069 ; 
PF00659
27.404 (57/208) 2.69E-16
Myosin light chain kinase family member 4 (MYLK4)
PF00069
28.500 (57/200) 2.93E-16
Tyrosine-protein kinase EIF2AK2 (p68)
PF00035 ; 
PF00069
26.695 (63/236) 4.24E-16
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)
PF00069
23.923 (50/209) 4.45E-16
Ribosomal protein S6 kinase alpha-5 (RSK5)
PF00069 ; 
PF00433
26.471 (54/204) 4.92E-16
Microtubule-associated serine/threonine-protein kinase 2 (MAST2)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 25.728 (53/206) 4.99E-16
PKC-delta-interacting protein kinase (RIPK4)
PF12796 ; 
PF00069
25.723 (80/311) 7.07E-16
Myosin light chain kinase 2 (MYLK2)
PF00069
26.263 (52/198) 8.90E-16
Apoptosis signal-regulating kinase 2 (MAP3K6)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 25.701 (55/214) 9.53E-16
Nik-related protein kinase (NRK)
PF00780 ; 
PF00069
28.571 (52/182) 1.03E-15
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
PF00780 ; 
PF00069
26.829 (55/205) 1.05E-15
Protein kinase C beta (PRKCB)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 27.273 (57/209) 1.06E-15
Ribosomal protein S6 kinase alpha-6 (RSK6)
PF00069 ; 
PF00433
25.121 (52/207) 1.10E-15
Homeodomain-interacting protein kinase 4 (HIPK4)
PF00069
26.316 (55/209) 1.40E-15
Protein kinase C iota (PRKCI)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 24.878 (51/205) 1.61E-15
Rhodopsin kinase GRK1 (GRK1)
PF00069 ; 
PF00615
24.522 (77/314) 1.92E-15
Serine/threonine-protein kinase WNK4 (WNK4)
PF12202 ; 
PF00069
28.708 (60/209) 1.95E-15
Protein kinase C gamma (PRKCG)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 26.728 (58/217) 2.12E-15
Stress-activated protein kinase 2a (p38 alpha)
PF00069
28.230 (59/209) 2.91E-15
Checkpoint kinase-1 (CHK1)
PF00069
29.412 (60/204) 3.38E-15
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
PF00069
24.501 (86/351) 4.24E-15
Calcium/calmodulin-dependent protein kinase type 1B (PNCK)
PF00069
25.000 (50/200) 4.27E-15
Mitogen-activated protein kinase kinase kinase 15 (MAP3K15)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 23.864 (63/264) 5.03E-15
Protein kinase C eta type (PRKCH)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 24.046 (63/262) 5.60E-15
Serine/threonine-protein kinase STK11 (STK11)
PF00069
24.224 (78/322) 6.71E-15
Serine/threonine-protein kinase H2 (PSKH2)
PF00069
23.556 (53/225) 7.12E-15
MAP kinase p38 (MAPK12)
PF00069
26.749 (65/243) 7.38E-15
Serine/threonine-protein kinase Nek10 (NEK10)
PF00069
23.345 (67/287) 8.25E-15
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
PF00069
25.424 (75/295) 8.41E-15
Ribosomal protein S6 kinase-related protein (RSKR)
PF00069
27.228 (55/202) 9.58E-15
Serine/threonine-protein kinase 32A (STK32A)
PF00069
25.909 (57/220) 9.61E-15
Ribosomal protein S6 kinase alpha-4 (RPS6KA4)
PF00069 ; 
PF00433
24.907 (67/269) 1.05E-14
Rho-associated protein kinase 1 (ROCK1)
PF00069 ; 
PF08912
27.404 (57/208) 1.11E-14
Extracellular signal-regulated kinase 5 (ERK5)
PF00069
27.358 (58/212) 1.27E-14
Cyclin-dependent kinase 6 (CDK6)
PF00069
25.217 (58/230) 1.41E-14
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
PF00069
25.743 (52/202) 1.41E-14
Endoplasmic reticulum to nucleus signaling 1 (ERN1)
PF00069 ; 
PF06479
24.765 (79/319) 1.41E-14
Serine/threonine-protein kinase WNK1 (WNK1)
PF12202 ; 
PF00069
27.645 (81/293) 1.73E-14
Apoptosis signal-regulating kinase 1 (MAP3K5)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 23.774 (63/265) 2.03E-14
Cyclin-dependent kinase-like 4 (CDKL4)
PF00069
22.609 (52/230) 2.09E-14
Cyclin-dependent kinase 15 (CDK15)
PF00069
22.596 (47/208) 2.27E-14
Serine/threonine-protein kinase NIK (MAP3K14)
PF00069
25.726 (62/241) 2.50E-14
CaM kinase-like vesicle-associated protein (CAMKV)
PF00069
25.980 (53/204) 2.86E-14
Inhibitor of nuclear factor kappa-B kinase alpha (IKKA)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 28.505 (61/214) 3.75E-14
Rho-associated protein kinase 2 (ROCK2)
PF00069 ; 
PF08912
26.923 (56/208) 5.61E-14
Polo-like kinase 1 (PLK1)
PF00069 ; 
PF00659
26.336 (69/262) 6.48E-14
Extracellular signal-regulated kinase 1 (ERK1)
PF00069
25.837 (54/209) 6.54E-14
IL-1 receptor-associated kinase 1 (IRAK1)
PF00531 ; 
PF00069
26.027 (57/219) 6.95E-14
Serine/threonine-protein kinase NLK (NLK)
PF00069
28.708 (60/209) 7.18E-14
Inhibitor of nuclear factor kappa-B kinase beta (IKKB)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 28.505 (61/214) 8.83E-14
Testis-specific serine/threonine-protein kinase 4 (TSSK4)
PF00069
27.014 (57/211) 9.89E-14
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1)
PF12796 ; 
PF16095 ; 
PF00069 ; 
PF08477
More >>
 31.250 (55/176) 9.92E-14
Yet another novel kinase 2 (STK32B)
PF00069
25.926 (56/216) 1.18E-13
Protein kinase C epsilon (PRKCE)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 26.087 (54/207) 1.34E-13
IL-1 receptor-associated kinase 3 (IRAK3)
PF00531 ; 
PF00069
24.476 (70/286) 1.58E-13
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
PF00069
24.257 (49/202) 2.05E-13
Bone morphogenetic protein receptor (BMPR2)
PF01064 ; 
PF00069
26.316 (60/228) 2.10E-13
Ribosomal protein S6 kinase beta-1 (S6K1)
PF00069 ; 
PF00433
25.714 (54/210) 2.13E-13
Serine/threonine-protein kinase 32C (STK32C)
PF00069
23.203 (71/306) 2.17E-13
Cyclin-dependent kinase 17 (CDK17)
PF12330 ; 
PF00069
26.699 (55/206) 2.48E-13
Cyclin-dependent kinase 14 (CDK14)
PF00069
25.592 (54/211) 2.52E-13
Testis-specific serine/threonine-protein kinase 3 (TSSK3)
PF00069
25.123 (51/203) 2.86E-13
Activin receptor type IB (ACVR1B)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 29.004 (67/231) 3.61E-13
Stress-activated protein kinase 2b (p38 beta)
PF00069
26.794 (56/209) 4.12E-13
NDR2 protein kinase (STK38L)
PF00069 ; 
PF00433
23.077 (60/260) 4.17E-13
Protein kinase N3 (PKN3)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 26.699 (55/206) 5.56E-13
Activin receptor type IIA (ACVR2A)
PF01064 ; 
PF00069
27.556 (62/225) 6.45E-13
Glycogen synthase kinase-3 alpha (GSK-3A)
PF00069
26.540 (56/211) 7.42E-13
Extracellular signal-regulated kinase 2 (ERK2)
PF00069
24.878 (51/205) 7.53E-13
Glycogen synthase kinase-3 beta (GSK-3B)
PF00069
25.279 (68/269) 1.09E-12
Leucine-rich repeat kinase 2 (LRRK2)
PF16095 ; 
PF12799 ; 
PF13855 ; 
PF00069 ; 
PF08477
More >>
 25.784 (74/287) 1.10E-12
TGF-beta receptor type I (TGFBR1)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 28.509 (65/228) 1.15E-12
Protein kinase C zeta (PRKCZ)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 23.697 (50/211) 1.19E-12
Calcium/calmodulin-dependent protein kinase type IV (CAMK4)
PF00069
28.000 (56/200) 1.23E-12
CaM-kinase IV kinase (CAMKK1)
PF00069
28.402 (48/169) 1.28E-12
Death-associated protein kinase 1 (DAPK1)
PF00023 ; 
PF12796 ; 
PF13637 ; 
PF00531 ; 
PF00069
More >>
 25.481 (53/208) 1.30E-12
Calmodulin-dependent kinase II (CAMKK2)
PF00069
26.180 (61/233) 1.56E-12
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
PF00069
24.878 (51/205) 1.67E-12
Cyclin-dependent kinase 18 (CDK18)
PF00069
29.078 (41/141) 1.95E-12
Stress-activated protein kinase JNK3 (JNK3)
PF00069
26.442 (55/208) 2.32E-12
ERK activator kinase 7 (MAP2K7)
PF00069
25.763 (76/295) 2.63E-12
Proto-oncogene serine/threonine-protein kinase mos (MOS)
PF00069
24.107 (54/224) 2.99E-12
PRKR-like endoplasmic reticulum kinase (PERK)
PF00069
36.000 (36/100) 3.92E-12
Cyclin-dependent kinase 16 (CDK16)
PF12330 ; 
PF00069
24.757 (51/206) 4.28E-12
Serine/threonine-protein kinase 35 (STK35)
PF00069
31.788 (48/151) 4.41E-12
Serine/threonine-protein kinase SBK1 (SBK1)
PF00069
26.667 (56/210) 4.86E-12
Stress-activated protein kinase JNK1 (JNK1)
PF00069
28.191 (53/188) 4.92E-12
Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3)
PF00069
25.333 (57/225) 5.64E-12
Protein kinase G1 (PRKG1)
PF00027 ; 
PF16808 ; 
PF00069
More >>
 23.270 (74/318) 6.40E-12
MAPK-activated protein kinase 2 (MAPKAPK2)
PF00069
26.442 (55/208) 6.77E-12
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)
PF00531 ; 
PF00069
29.348 (54/184) 7.62E-12
Serine/threonine-protein kinase cot (COT)
PF00069
24.878 (51/205) 9.27E-12
Membrane-associated kinase (PKMYT1)
PF00069
23.502 (51/217) 1.17E-11
Protein kinase N1 (PKN1)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 27.670 (57/206) 1.42E-11
MAPK-activated protein kinase 3 (MAPKAPK3)
PF00069
30.097 (62/206) 1.54E-11
Stress-activated protein kinase JNK2 (JNK2)
PF00069
24.583 (59/240) 1.57E-11
Cyclin-dependent kinase 4 (CDK4)
PF00069
23.176 (54/233) 1.63E-11
Mitogen-activated protein kinase 13 (MAPK13)
PF00069
25.366 (52/205) 2.09E-11
NDR1 protein kinase (STK38)
PF00069 ; 
PF00433
22.394 (58/259) 2.23E-11
Death-associated protein kinase 3 (DAPK3)
PF00069
24.382 (69/283) 2.36E-11
Ribosomal protein S6 kinase beta-2 (RPS6KB2)
PF00069 ; 
PF00433
23.462 (61/260) 2.55E-11
Serine/threonine-protein kinase PDIK1L (PDIK1L)
PF00069
29.252 (43/147) 2.65E-11
Large tumor suppressor homolog 2 (LATS2)
PF00069 ; 
PF00433
23.051 (68/295) 2.96E-11
Mitogen-activated protein kinase 4 (MAPK4)
PF00069
24.057 (51/212) 3.00E-11
Testis-specific serine kinase 2 (TSSK2)
PF00069
25.352 (54/213) 3.57E-11
Striated muscle preferentially expressed protein kinase (SPEG)
PF07679 ; 
PF00069 ; 
PF16650
More >>
 22.677 (61/269) 3.81E-11
Activin receptor type IIB (ACVR2B)
PF01064 ; 
PF00069
25.106 (59/235) 3.82E-11
Anti-mullerian hormone II receptor (AMHR2)
PF00069
25.564 (68/266) 3.85E-11
Cyclin-dependent kinase 10 (CDK10)
PF00069
27.907 (48/172) 4.09E-11
Protein kinase G2 (PRKG2)
PF00027 ; 
PF00069
23.438 (60/256) 5.37E-11
Serine/threonine-protein kinase/endoribonuclease IRE2 (ERN2)
PF00069 ; 
PF06479
26.939 (66/245) 5.96E-11
Serine/threonine-protein kinase MRCK gamma (CDC42BPG)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF00069
More >>
 23.182 (51/220) 1.04E-10
Testis-specific serine/threonine-protein kinase 1 (TSSK1B)
PF00069
22.917 (44/192) 1.08E-10
Beta-adrenergic receptor kinase 1 (ADRBK1)
PF00169 ; 
PF00069 ; 
PF00615
More >>
 24.883 (53/213) 1.97E-10
Cyclin-dependent kinase 19 (CDK19)
PF00069
30.114 (53/176) 2.22E-10
Testis-specific serine/threonine-protein kinase 6 (TSSK6)
PF00069
25.238 (53/210) 2.26E-10
Obscurin (OBSCN)
PF00041 ; 
PF07679 ; 
PF00612 ; 
PF00069 ; 
PF00621
More >>
 23.711 (46/194) 2.54E-10
Sugen kinase 110 (SBK3)
PF00069
30.070 (43/143) 2.85E-10
Cyclin-dependent kinase 11A (CDK11A)
PF00069
25.243 (52/206) 2.91E-10
Cyclin-dependent kinase 8 (CDK8)
PF00069
28.977 (51/176) 4.25E-10
Serine/threonine-protein kinase SBK2 (SBK2)
PF00069
27.273 (63/231) 4.31E-10
Protein kinase N2 (PKN2)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 27.184 (56/206) 4.57E-10
G protein-coupled receptor kinase 6 (GRK6)
PF00069 ; 
PF00615
28.155 (58/206) 5.07E-10
Cyclin-dependent kinase 11B (CDK11B)
PF00069
25.243 (52/206) 5.08E-10
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)
PF08332 ; 
PF00069
22.927 (47/205) 5.29E-10
Death-associated protein kinase 2 (DAPK2)
PF00069
25.604 (53/207) 5.42E-10
Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2)
PF00069
23.445 (49/209) 7.64E-10
Eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4)
PF12745 ; 
PF00069 ; 
PF05773 ; 
PF13393
More >>
 32.374 (45/139) 9.49E-10
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)
PF08332 ; 
PF00069
23.267 (47/202) 9.71E-10
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)
PF00069
33.654 (35/104) 9.94E-10
G protein-coupled receptor kinase 5 (GRK5)
PF00069 ; 
PF00615
25.490 (52/204) 1.20E-09
STE20-related kinase adapter protein alpha (STRADA)
PF00069
23.558 (49/208) 1.22E-09
CDC42 binding protein kinase alpha (DMPK-like alpha)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069 ; 
PF00433
More >>
 23.148 (50/216) 1.30E-09
Beta-adrenergic receptor kinase 2 (ADRBK2)
PF00169 ; 
PF00069 ; 
PF00615
More >>
 24.638 (51/207) 1.78E-09
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)
PF00069
23.529 (52/221) 1.92E-09
Adaptor-associated kinase 1 (AAK1)
PF00069
24.312 (53/218) 2.03E-09
Rhodopsin kinase GRK7 (GRK7)
PF00069 ; 
PF00615
24.348 (56/230) 2.40E-09
Cyclin-G-associated kinase (GAK)
PF00069 ; 
PF10409
23.881 (80/335) 3.30E-09
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)
PF08332 ; 
PF00069
21.782 (44/202) 3.42E-09
TGF-beta-stimulated factor 1 (STK16)
PF00069
22.182 (61/275) 3.58E-09
Phosphorylase kinase testis gamma 2 (PHKG2)
PF00069
21.659 (47/217) 3.61E-09
Serine/threonine-protein kinase MRCK beta (CDC42BPB)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069
More >>
 21.860 (47/215) 3.80E-09
Citron Rho-interacting kinase (CIT)
PF00780 ; 
PF00169 ; 
PF00069
More >>
 23.293 (58/249) 5.67E-09
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)
PF08332 ; 
PF00069
23.267 (47/202) 6.11E-09
Myotonin-protein kinase (DMPK)
PF08826 ; 
PF00069
22.422 (50/223) 6.19E-09
G protein-coupled receptor kinase 4 (GRK4)
PF00069 ; 
PF00615
24.638 (51/207) 7.17E-09
Serine/threonine-protein kinase PRP4 homolog (PRPF4B)
PF00069
25.243 (52/206) 8.11E-09
Mitogen-activated protein kinase 6 (MAPK6)
PF00069
26.144 (40/153) 8.74E-09
Serine/threonine-protein kinase LATS1 (LATS1)
PF00069 ; 
PF00627
23.308 (62/266) 1.06E-08
Dual-specificity tyrosine-phosphorylation regulated kinase 4 (DYRK4)
PF00069
24.519 (51/208) 1.06E-08
Serine/threonine-protein kinase 17B (STK17B)
PF00069
22.705 (47/207) 1.20E-08
MAPK-activated protein kinase 5 (MAPKAPK5)
PF00069
24.670 (56/227) 1.23E-08
PAS domain-containing serine/threonine-protein kinase (PASK)
PF13426 ; 
PF00069
21.296 (46/216) 1.24E-08
Serine/threonine-protein kinase ULK4 (ULK4)
PF00069
24.419 (42/172) 1.41E-08
MAP kinase signal-integrating kinase 2 (MKNK2)
PF00069
23.810 (50/210) 1.81E-08
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 22.897 (49/214) 2.80E-08
Homeodomain-interacting protein kinase 1 (HIPK1)
PF00069
23.810 (50/210) 2.86E-08
Cytoplasmic DRAK1 (STK17A)
PF00069
21.171 (47/222) 3.23E-08
MAPK/MAK/MRK overlapping kinase (MOK)
PF00069
23.585 (50/212) 3.44E-08
Homeodomain-interacting protein kinase 3 (HIPK3)
PF00069
23.810 (50/210) 6.12E-08
STE20-related kinase adapter protein beta (STRADB)
PF00069
23.390 (69/295) 8.46E-08
PDZ binding kinase (PBK)
PF00069
25.843 (46/178) 8.88E-08
Serine/threonine kinase-like domain-containing protein STKLD1 (STKLD1)
PF00069
25.472 (54/212) 1.43E-07
Homeodomain interacting protein kinase 2 (HIPK2)
PF00069
22.523 (50/222) 1.56E-07
Serine/threonine-protein kinase Chk2 (RAD53)
PF00498 ; 
PF00069
23.148 (50/216) 2.15E-07
Titin (TTN) 22.275 (47/211) 2.73E-07
NF-kappa-B-activating kinase (TBK1)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 22.857 (48/210) 2.95E-07
MAPK signal-integrating kinase 1 (MKNK1)
PF00069
20.158 (51/253) 9.15E-07
Wee1-like protein kinase 2 (WEE2)
PF00069
22.695 (64/282) 1.45E-06
Wee1-like protein kinase (WEE1)
PF00069
22.826 (63/276) 1.97E-06
Serine/threonine-protein kinase greatwall (MASTL)
PF00069
22.449 (33/147) 2.54E-06
Nuclear receptor-binding protein 2 (NRBP2)
PF00069
25.405 (47/185) 2.89E-06
Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)
PF00069
19.820 (44/222) 4.65E-06
BMP-2-inducible protein kinase (BMP2K)
PF15282 ; 
PF00069
25.581 (44/172) 5.50E-06
CDC-like kinase 3 (CLK3)
PF00069
22.422 (50/223) 1.27E-05
Triple functional domain protein (TRIO)
PF00650 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00018 ; 
PF00435
More >>
 22.483 (67/298) 1.70E-05
Casein kinase II alpha (CSNK2A1)
PF00069
29.358 (32/109) 3.30E-05
Tau-tubulin kinase (TTBK1)
PF00069
24.138 (35/145) 4.20E-05
TBC domain-containing protein kinase-like protein (TBCK)
PF00069 ; 
PF00566 ; 
PF00581
More >>
 20.635 (52/252) 4.36E-05
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)
PF00069
20.270 (45/222) 4.96E-05
Casein kinase II subunit alpha 3 (CSNK2A3)
PF00069
27.778 (40/144) 5.72E-05
Kalirin (KALRN)
PF13716 ; 
PF00041 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00435
More >>
 22.051 (43/195) 1.11E-04
Casein kinase II alpha prime (CSNK2A2)
PF00069
25.157 (40/159) 1.36E-04
Serine/threonine-protein kinase pim-2 (PIM2)
PF00069
21.404 (61/285) 2.19E-04
Tau-tubulin kinase 2 (TTBK2)
PF00069
23.490 (35/149) 2.47E-04
Casein kinase I alpha (CSNK1A1)
PF00069
24.837 (38/153) 2.97E-04
Serine/threonine-protein kinase 40 (STK40)
PF00069
28.155 (29/103) 3.17E-04
Serine/threonine-protein kinase tousled-like 1 (TLK1)
PF00069
24.138 (42/174) 4.26E-04
Casein kinase I epsilon (CSNK1E)
PF00069
24.183 (37/153) 7.35E-04
Casein kinase I gamma-1 (CSNK1G1)
PF12605 ; 
PF00069
26.966 (24/89) 7.54E-04
Casein kinase I delta (CSNK1D)
PF00069
24.026 (37/154) 1.00E-03
Serine/threonine-protein kinase tousled-like 2 (TLK2)
PF00069
24.571 (43/175) 1.00E-03
Casein kinase I gamma-3 (CSNK1G3)
PF12605 ; 
PF00069
25.843 (23/89) 2.00E-03
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)
PF00069
31.532 (35/111) 3.00E-03
  Click to Show/Hide the Information of Human Similarity Proteins
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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KEGG Pathway Pathway ID Affiliated Target Pathway Map
Axon guidance hsa04360 Affiliated Target
  Class: Organismal Systems => Development and regeneration Pathway Hierarchy
Fc gamma R-mediated phagocytosis hsa04666 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
Regulation of actin cytoskeleton hsa04810 Affiliated Target
  Class: Cellular Processes => Cell motility Pathway Hierarchy
Degree 10 Degree centrality 1.07E-03 Betweenness centrality 3.58E-05
Closeness centrality 2.16E-01 Radiality 1.38E+01 Clustering coefficient 2.22E-01
Neighborhood connectivity 3.22E+01 Topological coefficient 1.55E-01 Eccentricity 12
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