Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T70840 | Target Info | |||
| Target Name | LIM domain kinase-1 (LIMK-1) | ||||
| Synonyms |
LIMK-1; LIMK
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| Target Type | Literature-reported Target | ||||
| Gene Name | LIMK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 31 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-[6-(2-Chloro-4-ethoxyphenyl)-2-(2-fluorophenyl)pyrimidin-4-yl]-N-propan-2-yl-1,3-thiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070490; SCHEMBL12716430; BDBM50390772
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
4-Phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-6-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219030
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
3-Amino-6-methylthieno[2,3-b]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL568904; Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-6-methyl-; 3-amino-6-methylthiopheno[2,3-b]pyridine-2-carboxamide; Cambridge id 5277481; Oprea1_011832; Oprea1_344293; SCHEMBL16071461; CTK6C0706; RSCBB000303; HMS1620A15; ZINC241742; 3-Amino-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid amide; BDBM50302209; RSC002069; SBB093885; STK870606; AKOS000667919; CCG-123009; MCULE-6303649796; ST097747; AB00078787-01; AM-807/25050025; SR-01000507921; SR-01000507921-1; 3-amino-6-methyl-thieno[2,3-b]pyridine-2-carboxamide; 3-amino-6-methylthieno[5,4-b]pyridine-2-carboxamide; 3-amino-6-methylthieno[2,3-b]pyridine-2-carboxamide, AldrichCPR
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| Activity |
IC50 = 56000 nM
|
[2] | |||
| Compound Name |
Thieno[3,2-b]pyridine-2-carboxamide, 3-amino-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219021; 3-amino-2-carbamoylthienopyridine; AKOS017529765; 3-aminothieno[3,2-b]pyridine-2-carboxamide
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| Activity |
IC50 = 92000 nM
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[2] | |||
| Compound Name |
2-Methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836474; NSC349834; Oprea1_297955; Oprea1_825231; CBDivE_014682; ZINC58313; DTXSID50319715; BDBM50354360; STK746478; 2-Methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamine; AKOS001569758; MCULE-5635603252; NSC-349834; SR-01000399438; SR-01000399438-1; 2-Methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine; 4-Amino-5,6,7,8-tetrahydro-2-methyl[1]benzothieno[2,3-d]pyrimidine
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N,N-Dimethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1165129; SCHEMBL10237103; HMS1748A02; ZINC406381; BDBM50354371; MFCD01192168; STL264154; AKOS001157125; CCG-314847; MCULE-3071720282; Z31222639; N,N-dimethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine; DIMETHYL-(5,6,7,8-TETRAHYDRO-BENZO(4,5)THIENO(2,3-D)PYRIMIDIN-4-YL)-AMINE
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-methyl-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219014; AKOS014967868
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-(Methylsulfanyl)-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836480; Cambridge id 6032726; Oprea1_114936; Oprea1_120081; SMSF0011671; ZINC3683264; BDBM50354367; STK993853; AKOS000510263; CB01322; MCULE-9748655336; AB00102109-01; AJ-292/13889628; SR-01000486055; SR-01000486055-1
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
2-Thiophen-2-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836479; ZINC419889; BDBM50354366; AKOS006049336; MCULE-6861713444
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
[(4-Amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)sulfanyl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836478; ZINC356734; BDBM50354365; SBB043049; STK722714; AKOS000269120; MCULE-3981242582; 2-(4-amino-5,6,7,8-tetrahydrobenzo[b]thiopheno[2,3-d]pyrimidin-2-ylthio)acetic acid
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
3-Aminothieno[2,3-b]pyridine-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
UNII-7KY2XKT1CE; NSC284503; 7KY2XKT1CE; 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLICACID; 3-Aminothieno(2,3-b)pyridine-2-carboxylic acid; MFCD03783349; NSC 284503; Maybridge4_002771; Thieno[2,3-b]pyridine-2-carboxylic acid, 3-amino-; SCHEMBL3836628; CHEMBL3219022; CTK1H3719; KS-00000CZX; DTXSID30207060; BDBM105192; HMS1528N21; ZINC161955; ALBB-004830; 6048AE; BBL012476; STK262264; AKOS000321482; MCULE-1286863964; NSC-284503; QC-5921; SDCCGMLS-0066167.P001; VP11155; IDI1_032649; 3-amino-2-carboxythieno[2,3-b]pyridine; AS-10386; SY035628; AB0096407; BB 0257294; CS-0044445; FT-0615073; ST50765016; Y-0836; 3-aminothiopheno[2,3-b]pyridine-2-carboxylic acid; Thieno[2,3-b]pyridine-2-carboxylicacid, 3-amino-; Z274771330; 3-Aminothieno[2,3-b]pyridine-2-carboxylic acid, AldrichCPR
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-(Methylthio)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836476; VU0029251; Cambridge id 5705272; AOB1034; HMS1582G15; ZINC346432; BDBM50354363; SBB043038; STK015253; AKOS000269213; MCULE-4645144533; VU0029251, >=98% (HPLC), powder; VU0029251-3; AB00094087-01; 2-(methylsulfanyl)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N-Methyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-3-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836481; Oprea1_586280; SCHEMBL10237224; ZINC40425; BDBM50354368; AKOS001089966; MCULE-5591515905; SR-01000061325; SR-01000061325-1; Z31222809
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
2-Phenyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamine
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Investigative | Compound Info | ||
| Synonyms |
MLS000561401; SMR000177806; 2-phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine; NSC357373; TimTec1_006635; CBDivE_000691; cid_337817; CHEMBL1556240; SCHEMBL15176754; BDBM49587; DTXSID00320295; HMS1552N13; HMS2555F24; ZINC3071497; 2-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine; STL362903; AKOS000566117; MCULE-8244062124; NSC-357373; (2-phenyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)amine; 2-Phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-amine
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
4-(1-Piperidinyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836484; 4-(piperidin-1-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine; NSC333010; Oprea1_172164; Oprea1_428334; CBDivE_010436; SCHEMBL13641084; DTXSID60330916; ZINC2478978; BDBM50354373; CCG-15274; STK366832; AKOS000520799; MCULE-4041384487; NSC-333010; ST50908725; AG-690/10484056; SR-01000392414; SR-01000392414-1; Z31192739; 4-piperidyl-5,6,7,8-tetrahydrobenzo[b]thiopheno[2,3-d]pyrimidine
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
4-Amino-6,7,8,9-tetrahydro-5H-10-thia-1,3-diaza-benzo[a]azulene-2-thiol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836475; Oprea1_780800; SCHEMBL20254470; CTK8A8361; CTK8F5755; ZINC3886247; BDBM50354362; SBB078019; STK996251; AKOS001055432; AKOS001637414; MCULE-9836825187; NE59681; EU-0041864; EN300-05137; SR-01000465252; SR-01000465252-1; 3-amino-8-thia-4,6-diazatricyclo[7.5.0.02,7]tetradeca-1(9),2,6-triene-5-thione; 4-amino-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidine-2-thiol
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
Benzo[b]thiophene-2-carboxamide, 3-hydroxy-
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Investigative | Compound Info | ||
| Synonyms |
hydroxybenzothiophene amide; SCHEMBL649968; CHEMBL3219020; SCHEMBL11074064; 3-hydroxy-1-benzothiophene-2-carboxamide
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-Amino-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2-thiol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836477; Oprea1_264122; SCHEMBL1621786; CTK8A8360; CTK8F5704; BDBM50354364; CCG-18497; SBB043045; STK847006; ZINC17837262; 4-amino-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidine-2-thione; AKOS000269110; AKOS005136936; MCULE-5267753674; EN300-05310; SR-01000465253; SR-01000465253-1; 4-amino-1,5,6,7,8-pentahydrobenzo[b]thiopheno[2,3-d]pyrimidine-2-thione; 4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-2(1H)-thione; 4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-2-thiol; 3-amino-8-thia-4,6-diazatricyclo[7.4.0.0?,?]trideca-1(9),2,4,6-tetraene-5-thiol
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
3-Amino-1-benzothiophene-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
3-Aminobenzo[b]thiophene-2-carboxylic acid; 3-Amino-benzenethiophene-2-carboxylic acid; Benzo[b]thiophene-2-carboxylic acid, 3-amino-; SCHEMBL1919937; CHEMBL3219017; CTK1D5442; KS-00002ADS; DTXSID80371649; ZINC2523132; 2607AE; MFCD04035724; SBB053261; 3-aminobenzo[b]thiophene-2-carboxylic; AKOS001770447; CCG-125305; MCULE-8177351868; PS-5244; 3-amino-benzo[b]thiophene-2-carboxylic acid; FT-0714168; Benzo[b]thiophene-2-carboxylicacid, 3-amino-; 3-amino-benzenethiophene-2-carboxylic acid, AldrichCPR
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-Aminobenzofuran-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
3-Amino-1-benzofuran-2-carboxamide; 3-aminobenzo[b]furan-2-carboxamide; ChemDiv1_012159; Oprea1_002963; SCHEMBL1006030; CHEMBL3219019; HMS621I15; 3-amino-benzofuran-2-carboxamide; 3-aminobenzo-furan-2-carboxamide; DTXSID20344933; 2-Benzofurancarboxamide, 3-amino-; ACT09839; ALBB-019727; BCP09362; ZINC2565589; 5421AE; Benzofurane-2-carboxamide, 3-amino-; MFCD00457147; SBB014414; STK762912; AKOS001136061; 3-Amino-1-benzofuran-2-carboxamide #; 3-Aminobenzofuran-2-carboxamide, 97%; CS-W017411; DS-9163; MCULE-8325698534; SDCCGMLS-0065576.P001; 3-AMINO BENZOFURAN-2-CARBOXAMIDE; AK176332; ST4055983; 3-AMINOBENZOFURAN-2-CARBOXAMIDE 97; BB 0261511; FT-0698567; A-8657; F1607-0392
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
N-(2-Phenylethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271896; Oprea1_006274; Oprea1_826054; ZINC354171; BDBM50354372; STK506924; AKOS002053351; CCG-195254; MCULE-3134101664; ST50050510; Z31198379; (2-phenylethyl)-5,6,7,8-tetrahydrobenzo[b]thiopheno[3,2-e]pyrimidin-4-ylamine
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N'-(5,6,7,8-Tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)ethane-1,2-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836482; BDBM50354369; SR-01000324963; SR-01000324963-1
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
Ethyl 3-aminobenzo[b]thiophene-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
ethyl 3-amino-1-benzothiophene-2-carboxylate; 3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER; ethyl 3-aminobenzothiophene-2-carboxylate; 3-Aminobenzo[b]thiophene-2-carboxylic acid ethyl ester; MFCD00661903; Benzo[b]thiophene-2-carboxylic acid, 3-amino-, ethyl ester; Maybridge1_003360; BEN789; SCHEMBL7215848; CHEMBL3219016; CTK4H2997; HMS551A16; DTXSID60352658; ZINC145157; ALBB-021576; KS-00000NH8; 3-Amino-2-carboethoxy-benzothiophene; BBL006365; CCG-46019; HTS004171; SBB023862; STK350918; AKOS000281331; BS-4299; DS-3095; MCULE-9721329011; AK-65257; AB0003263; DB-108805; ST45160825; V5365; EN300-53562; K-7902; 761A096; SR-01000635748-1; F1606-0080; Z810541814; Benzo[b]thiophene-2-carboxylicacid, 3-amino-, ethyl ester
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-Aminothieno[2,3-b]pyridine-2-carbohydrazide
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Investigative | Compound Info | ||
| Synonyms |
2-???thiopheno[2,3-b]pyridine-3-ylamine; 3-aminothieno[2,3-b]pyridine-2-carboxylic acid hydrazide; CHEMBL3219015; SCHEMBL16071455; CTK7F0953; ALBB-004839; ZINC6658028; MFCD08142645; SBB014190; STK262295; AKOS000321689; MCULE-8862422544; ST4132537
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamino)ethanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269735; Maybridge4_000880; Oprea1_663473; Oprea1_769934; SCHEMBL13164911; HMS1523H22; ZINC1908908; BDBM50330226; STL352920; AKOS001061705; CCG-240373; MCULE-3530764057; IDI1_031462; ST50447514; Z31212207; 2-(5,6,7,8-TETRAHYDRO-BENZO(4,5)THIENO(2,3-D)PYRIMIDIN-4-YLAMINO)-ETHANOL; 2-(5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-ylamino)-1-ethanol; 2-(5,6,7,8-tetrahydrobenzo[b]thiopheno[3,2-e]pyrimidin-4-ylamino)ethan-1-ol
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
2-(Methylsulfanyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamine
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Investigative | Compound Info | ||
| Synonyms |
GNF-Pf-2787; CHEMBL575039; Cambridge id 6150500; ZINC2956380; BDBM50354361; SBB043046; STK829926; AKOS000269111; MCULE-6754146051; AE-848/15341060; SR-01000454704; SR-01000454704-1; 4-Amino-5,6,7,8-tetrahydro-2-methylthio[1]benzothieno[2,3-d]pyrimidine; 2-(methylsulfanyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine; 2-(Methylthio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine; 2-methylthio-5,6,7,8-tetrahydrobenzo[b]thiopheno[2,3-d]pyrimidine-4-ylamine
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
Pyrazino[1,2]thieno[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153541; BDBM50392610
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-Amino-N,N-dimethylthieno[2,3-b]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217769; SCHEMBL16071475; Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N,N-dimethyl-; BBL026988; STL365296; ZINC10011141; AKOS014965197; MCULE-6263903475; H7578
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Benzo[b]thiophene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
1-Benzothiophene-2-carboxamide; Thianaphthene-2-carboxamide; Benzo(b)thiophene-2-carboxamide; MFCD00052505; decanoicacid; NSC40286; benzothiophene-2-amide; benzothiophene carboxamide; SCHEMBL347544; 2-benzo[b]thiophenecarboxamide; CHEMBL538197; SCHEMBL3848162; ZINC42562; DTXSID90285046; 1-Benzothiophene-2-carboxamide #; KS-00003T9K; NSC-40286; SBB055962; AKOS001568030; MCULE-8747688649; ST020045; TS-02463; DB-054412; FT-0622689; A834241; SR-01000392193; SR-01000392193-1; Z87614971
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(4-Methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1165229; Oprea1_338945; Oprea1_520313; HMS1897H19; ZINC1269756; BDBM50354370; STK823353; STL041363; AKOS000667375; AKOS005695009; CCG-100185; MCULE-8673386595; NCGC00134289-01; ST50000288; G786-0976; N-(4-Methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-amine
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(1-Phenylethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836483; STK953595; AKOS001329119; AKOS016298338; MCULE-1320843476; UPCMLD0ENAT5747930:001; ST50080571; Z31195311; (phenylethyl)-5,6,7,8-tetrahydrobenzo[b]thiopheno[3,2-e]pyrimidin-4-ylamine
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
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| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
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| Activity |
IC50 = 759000 nM
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[4] | |||
| References | Top | ||||
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| REF 1 | Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. | ||||
| REF 2 | Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors. Medchemcomm. 2011;2:977-81. | ||||
| REF 3 | Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5992-4. | ||||
| REF 4 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
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