Target Information
| Target General Information | Top | |||||
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| Target ID |
T37505
(Former ID: TTDI03249)
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| Target Name |
Striatum-specific G-protein coupled receptor (GPR88)
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| Synonyms |
STRG; Probable G-protein coupled receptor 88
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| Gene Name |
GPR88
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.
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| UniProt ID | ||||||
| Sequence |
MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFR
KLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLL GLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWA PRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGC AAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPL VWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAA AVAATAVPAVSQAQLGTRAAGQHW Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | AlphaFold | ||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand | PDB:7EJX | ||||
| Method | Electron microscopy | Resolution | 2.40 Å | Mutation | Yes | [2] |
| PDB Sequence |
LYSGLAIGGT
46 LANGMVIYLV56 SSFRKLQTTS66 NAFIVNGCAA76 DLSVCALWMP86 RLLRGGLLGL 122 GLTVSLLSHC132 LVALNRYLLI142 TRAPATYQAL152 YQRRHTAGML162 ALSWALALGL 172 VLLLPPWAHY192 PALLAAAALL202 AQTALLLHCY212 LGIVRRVRVS222 VKRVSVRLSG 283 LSVLLLCCVF293 LLATQPLVWV303 SLASGFSLPV313 PWGVQAASWL323 LCCALSALNP 333 LLYTWRNEEF343 RRSVRSVLP
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| Ligand Name: PMID24793972C2 | Ligand Info | |||||
| Structure Description | Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand | PDB:7EJX | ||||
| Method | Electron microscopy | Resolution | 2.40 Å | Mutation | Yes | [2] |
| PDB Sequence |
LYSGLAIGGT
46 LANGMVIYLV56 SSFRKLQTTS66 NAFIVNGCAA76 DLSVCALWMP86 RLLRGGLLGL 122 GLTVSLLSHC132 LVALNRYLLI142 TRAPATYQAL152 YQRRHTAGML162 ALSWALALGL 172 VLLLPPWAHY192 PALLAAAALL202 AQTALLLHCY212 LGIVRRVRVS222 VKRVSVRLSG 283 LSVLLLCCVF293 LLATQPLVWV303 SLASGFSLPV313 PWGVQAASWL323 LCCALSALNP 333 LLYTWRNEEF343 RRSVRSVLP
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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| Chemical Structure based Activity Landscape of Target | Top |
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| Target Poor or Non Binders | Top | |||||
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| Target Poor or Non Binders | ||||||
| References | Top | |||||
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| REF 1 | Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. | |||||
| REF 2 | Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex. Nat Commun. 2022 May 2;13(1):2375. | |||||
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