Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T37505 | Target Info | |||
| Target Name | Striatum-specific G-protein coupled receptor (GPR88) | ||||
| Synonyms | STRG; Probable G-protein coupled receptor 88 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GPR88 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand | PDB:7EJX | ||||
| Method | Electron microscopy | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
LYSGLAIGGT
46 LANGMVIYLV56 SSFRKLQTTS66 NAFIVNGCAA76 DLSVCALWMP86 RLLRGGLLGL 122 GLTVSLLSHC132 LVALNRYLLI142 TRAPATYQAL152 YQRRHTAGML162 ALSWALALGL 172 VLLLPPWAHY192 PALLAAAALL202 AQTALLLHCY212 LGIVRRVRVS222 VKRVSVRLSG 283 LSVLLLCCVF293 LLATQPLVWV303 SLASGFSLPV313 PWGVQAASWL323 LCCALSALNP 333 LLYTWRNEEF343 RRSVRSVLP
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| Ligand Name: PMID24793972C2 | Ligand Info | |||||
| Structure Description | Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand | PDB:7EJX | ||||
| Method | Electron microscopy | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
LYSGLAIGGT
46 LANGMVIYLV56 SSFRKLQTTS66 NAFIVNGCAA76 DLSVCALWMP86 RLLRGGLLGL 122 GLTVSLLSHC132 LVALNRYLLI142 TRAPATYQAL152 YQRRHTAGML162 ALSWALALGL 172 VLLLPPWAHY192 PALLAAAALL202 AQTALLLHCY212 LGIVRRVRVS222 VKRVSVRLSG 283 LSVLLLCCVF293 LLATQPLVWV303 SLASGFSLPV313 PWGVQAASWL323 LCCALSALNP 333 LLYTWRNEEF343 RRSVRSVLP
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex. Nat Commun. 2022 May 2;13(1):2375. | ||||
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