Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T12581
(Former ID: TTDI03296)
|
|||||
| Target Name |
IP3 receptor isoform 3 (ITPR3)
|
|||||
| Synonyms |
Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor; InsP3R3; Inositol 1,4,5-trisphosphate receptor type 3; IP3R 3
Click to Show/Hide
|
|||||
| Gene Name |
ITPR3
|
|||||
| Target Type |
Literature-reported target
|
[1] | ||||
| Function |
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Click to Show/Hide
|
|||||
| BioChemical Class |
Ryanodine-inositol triphosphate calcium channel
|
|||||
| UniProt ID | ||||||
| Sequence |
MSEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVC
PMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGS VIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVG DKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDV VRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHW NGLYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHG NDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTC PTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLV FFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEE LSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLH NNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPK NSDILIRTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNA HDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASFCHL MLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFVEDY LNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPA MLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKFEENE DIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSTT ANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQLLFK HFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKGEEVE AGAAKDKKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNM DAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLE AETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDM IMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKN VYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTL FENFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFSSPFSENSTSLQTHQTIVVQ LLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDAHISSMLSSGASCAA AAQRNASSYKATTRAFPRVTPTANQWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDV LHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIKVLRTLQQMLLKKTKYG DRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTGLDPDWSAIAATQCRLDKEGATKLVCDL ITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQET KSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRYSLGPSLRRGHEVSERVQS SEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTG GLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISP LCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERE NSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQML KSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTE QDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIA FFYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRYSIRPLIVALILRSIYYLGIGP TLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELF YSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVD RLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTERACDTLLM CIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTF ADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNK TDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMKLVSHLT AQLNELKEQMTEQRKRRQRLGFVDVQNCISR Click to Show/Hide
|
|||||
| Cell-based Target Expression Variations | Top | |||||
|---|---|---|---|---|---|---|
| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Adenosine triphosphate | Ligand Info | |||||
| Structure Description | IP3, ATP, and Ca2+ bound type 3 IP3 receptor in the inactive state | PDB:7T3U | ||||
| Method | Electron microscopy | Resolution | 3.70 Å | Mutation | No | [2] |
| PDB Sequence |
SSFLHIGDIV
14 SLYAEGSVNG24 FISTLGLVDD34 RCVVEPAAGD44 LDNPPKKFRD54 CLFKVCPMNR 64 YSAQKQYWKA74 KQTDVVLLQK92 LQHAAQMEQK102 QNDTENKKVH112 GDVVKYGSVI 122 QLLHMKSNKY132 LTVNKRLPAL142 LEKNAMRVTL152 DATGNEGSWL162 FIQPFWKLRS 172 NGDNVVVGDK182 VILNPVNAGQ192 PLHASNYELS202 DNAGCKEVNS212 VNCNTSWKIN 222 LFMQFVLKGG238 DVVRLFHAEQ248 EKFLTCDEYK258 GKLQVFLRTT268 LRQSATSATS 278 SNALWEVEVV288 HLYRFKHLAT311 GNYLAAEENK351 YCLVAVPHGN361 DIASLFELDP 371 TYVRLRHLCT394 NTWIQSTNVP404 IDIEEERPIR414 LMLGTCPTKE424 DKEAFAIVSV 434 PVSEIRDLDF444 ANDASSMLAS454 AVEKLNEGFI464 SQNDRRFVIQ474 LLEDLVFFVS 484 DVPNNGQNVL494 DIMVTKPNRE504 RQKLMREQNI514 LKQVFGILKA524 PFRPLVRLEE 540 LSDQKNAPYQ550 HMFRLCYRVL560 RHSQEDYRKN570 QEHIAKQFGM580 MQSQIGYDIL 590 AEDTITALLH600 NNRKLLEKHI610 TKTEVETFVS620 LVRKNREPRF630 LDYLSDLCVS 640 NHIAIPVTQE650 LICKCVLDPK660 NSDILIRTEL670 RPEVWLTWTD698 KNNEHHEKSV 708 RQLAQEARAG718 NAHDENVLSY728 YRYQLKLFAR738 MCLDRQYLAI748 DEISQQLGVD 758 LIFLCMADEM768 LPFDLRASFC778 HLMLHVHVDR788 DPQELVTPVK798 FARLWTEIPT 808 AITIKDYDSN818 LNNKFANTME835 FVEDYLNNVV845 SEAVPFANEE855 KNKLTFEVVS 865 LAHNLIYFGF875 YSFSELLRLT885 RTLLGIIDCD961 IVVMETKLKI971 LEILQFILNV 981 RLDYRISYLL991 SVFKKEFLDR1027 IGEQAEAMFG1037 SMLEVDDEGG1052 RMFLRVLIHL 1062 TMHDYAPLVS1072 GALQLLFKHF1082 SQRQEAMHTF1092 KQVQLLISAQ1102 DVENYKVIKS 1112 ELDRLRTMVE1122 KNYQIVKGIL1176 ERLNKMCQMR1190 KKQQRLLKNM1200 DAHKVMLDLL 1210 QIPYDKGDAK1220 MMEILRYTHQ1230 FLQKFCAGNP1240 GNQALLHKHL1250 HLFLTPGLLE 1260 AETMQHIFLN1270 NYQLCSEISE1280 PVLQHFVHLL1290 ATHGRHVQYL1300 DFLHTVIKAD 1319 MIMTELTNAG1329 DDVVVFYNDK1339 ASLAHLLDMM1349 KAARDGVEDH1359 SPLMYHISLV 1369 DLLAACAEGK1379 NVYTEIKCTS1389 LLPLEDVVSV1399 VTHEDCITEV1409 KMAYVNFVNH 1436 IWTLFENFTL1446 DMARVCSDPT1463 LEKYVLSVVL1473 DTINAFFSSP1483 FSENSTSLQT 1493 HQTIVVQLLQ1503 STTRLLECPW1513 LQQQHKGSVE1523 ACIRTLAMVK1589 NIIEKLQDII 1599 TALEERLKPL1609 VQAELSVLVD1619 VLHWPELLFL1629 EGSEAYQRCE1639 SGGFLSKLIQ 1649 HTKDLMESEE1659 KLCIKVLRTL1669 QQMLLKKTKY1679 GDRGNQLRKM1689 LLQNYLQSAI 1721 AATQCRLDKE1731 GATKLVCDLI1741 TSTKNEKIFQ1751 ESIGLAIHLL1761 DGGNTEIQKS 1771 FHNLMMSDKK1781 SERFFKVLHD1791 RMKRAQQETT1865 SVLIMQPILR1875 FLQLLCENHN 1885 RDLQNFLRCQ1895 NNKTNYNLVC1905 ETLQFLDIGL1924 LGLYINEDNV1934 GLVIQTLETL 1944 TEYCQGPCHE1954 NQTCIVTHES1964 NGIDIITALI1974 LNDLVLQLKD1994 NASKLLLALM 2004 ESNAERILIS2019 LRPQELVDVI2029 KKAYLVSPRE2048 VGHNIYILAL2058 QLSRHNKQLQ 2068 HLLKPDPLAY2116 YENHTSQIEI2126 VRQDRSMEQI2136 VFPVPGICQF2146 LTEETKHRLF 2156 TTTEQDEQGS2166 KVSDFFDQSS2176 FLHNEMEWQR2186 KLRSMPLIYW2196 FSRRMTLWGS 2206 ISFNLAVFIN2216 IIIAFFYPYI2261 RPLIVALILR2271 SIYYLGIGPT2281 LNILGALNLT 2291 NKIVFVVSFV2301 GNRMEFLYHV2324 GYILTSVLGL2334 FAHELFYSIL2344 LFDLIYREET 2354 LFNVIKSVTR2364 NGRSILLTAL2374 LALILVYLFS2384 IVGFLFLKDD2394 FILEVDRLST 2451 ERACDTLLMC2461 IVTVMNHGLR2471 NGGGVGDILR2481 KPSKDESLFP2491 ARVVYDLLFF 2501 FIVIIIVLNL2511 IFGVIIDTFA2521 DLRSEKQKKE2531 EILKTTCFIC2541 GLERDKFDNK 2551 TVSFEEHIKL2561 EHNMWNYLYF2571 IVLVRVKNKT2581 DYTGPESYVA2591 QMIKNKNLDW 2601 FPRMRAMSLV2611
|
|||||
|
|
||||||
| Ligand Name: D-myo-inositol 1,4,5-trisphosphate | Ligand Info | |||||
| Structure Description | IP3, ATP, and Ca2+ bound type 3 IP3 receptor in the inactive state | PDB:7T3U | ||||
| Method | Electron microscopy | Resolution | 3.70 Å | Mutation | No | [2] |
| PDB Sequence |
SSFLHIGDIV
14 SLYAEGSVNG24 FISTLGLVDD34 RCVVEPAAGD44 LDNPPKKFRD54 CLFKVCPMNR 64 YSAQKQYWKA74 KQTDVVLLQK92 LQHAAQMEQK102 QNDTENKKVH112 GDVVKYGSVI 122 QLLHMKSNKY132 LTVNKRLPAL142 LEKNAMRVTL152 DATGNEGSWL162 FIQPFWKLRS 172 NGDNVVVGDK182 VILNPVNAGQ192 PLHASNYELS202 DNAGCKEVNS212 VNCNTSWKIN 222 LFMQFVLKGG238 DVVRLFHAEQ248 EKFLTCDEYK258 GKLQVFLRTT268 LRQSATSATS 278 SNALWEVEVV288 HLYRFKHLAT311 GNYLAAEENK351 YCLVAVPHGN361 DIASLFELDP 371 TYVRLRHLCT394 NTWIQSTNVP404 IDIEEERPIR414 LMLGTCPTKE424 DKEAFAIVSV 434 PVSEIRDLDF444 ANDASSMLAS454 AVEKLNEGFI464 SQNDRRFVIQ474 LLEDLVFFVS 484 DVPNNGQNVL494 DIMVTKPNRE504 RQKLMREQNI514 LKQVFGILKA524 PFRPLVRLEE 540 LSDQKNAPYQ550 HMFRLCYRVL560 RHSQEDYRKN570 QEHIAKQFGM580 MQSQIGYDIL 590 AEDTITALLH600 NNRKLLEKHI610 TKTEVETFVS620 LVRKNREPRF630 LDYLSDLCVS 640 NHIAIPVTQE650 LICKCVLDPK660 NSDILIRTEL670 RPEVWLTWTD698 KNNEHHEKSV 708 RQLAQEARAG718 NAHDENVLSY728 YRYQLKLFAR738 MCLDRQYLAI748 DEISQQLGVD 758 LIFLCMADEM768 LPFDLRASFC778 HLMLHVHVDR788 DPQELVTPVK798 FARLWTEIPT 808 AITIKDYDSN818 LNNKFANTME835 FVEDYLNNVV845 SEAVPFANEE855 KNKLTFEVVS 865 LAHNLIYFGF875 YSFSELLRLT885 RTLLGIIDCD961 IVVMETKLKI971 LEILQFILNV 981 RLDYRISYLL991 SVFKKEFLDR1027 IGEQAEAMFG1037 SMLEVDDEGG1052 RMFLRVLIHL 1062 TMHDYAPLVS1072 GALQLLFKHF1082 SQRQEAMHTF1092 KQVQLLISAQ1102 DVENYKVIKS 1112 ELDRLRTMVE1122 KNYQIVKGIL1176 ERLNKMCQMR1190 KKQQRLLKNM1200 DAHKVMLDLL 1210 QIPYDKGDAK1220 MMEILRYTHQ1230 FLQKFCAGNP1240 GNQALLHKHL1250 HLFLTPGLLE 1260 AETMQHIFLN1270 NYQLCSEISE1280 PVLQHFVHLL1290 ATHGRHVQYL1300 DFLHTVIKAD 1319 MIMTELTNAG1329 DDVVVFYNDK1339 ASLAHLLDMM1349 KAARDGVEDH1359 SPLMYHISLV 1369 DLLAACAEGK1379 NVYTEIKCTS1389 LLPLEDVVSV1399 VTHEDCITEV1409 KMAYVNFVNH 1436 IWTLFENFTL1446 DMARVCSDPT1463 LEKYVLSVVL1473 DTINAFFSSP1483 FSENSTSLQT 1493 HQTIVVQLLQ1503 STTRLLECPW1513 LQQQHKGSVE1523 ACIRTLAMVK1589 NIIEKLQDII 1599 TALEERLKPL1609 VQAELSVLVD1619 VLHWPELLFL1629 EGSEAYQRCE1639 SGGFLSKLIQ 1649 HTKDLMESEE1659 KLCIKVLRTL1669 QQMLLKKTKY1679 GDRGNQLRKM1689 LLQNYLQSAI 1721 AATQCRLDKE1731 GATKLVCDLI1741 TSTKNEKIFQ1751 ESIGLAIHLL1761 DGGNTEIQKS 1771 FHNLMMSDKK1781 SERFFKVLHD1791 RMKRAQQETT1865 SVLIMQPILR1875 FLQLLCENHN 1885 RDLQNFLRCQ1895 NNKTNYNLVC1905 ETLQFLDIGL1924 LGLYINEDNV1934 GLVIQTLETL 1944 TEYCQGPCHE1954 NQTCIVTHES1964 NGIDIITALI1974 LNDLVLQLKD1994 NASKLLLALM 2004 ESNAERILIS2019 LRPQELVDVI2029 KKAYLVSPRE2048 VGHNIYILAL2058 QLSRHNKQLQ 2068 HLLKPDPLAY2116 YENHTSQIEI2126 VRQDRSMEQI2136 VFPVPGICQF2146 LTEETKHRLF 2156 TTTEQDEQGS2166 KVSDFFDQSS2176 FLHNEMEWQR2186 KLRSMPLIYW2196 FSRRMTLWGS 2206 ISFNLAVFIN2216 IIIAFFYPYI2261 RPLIVALILR2271 SIYYLGIGPT2281 LNILGALNLT 2291 NKIVFVVSFV2301 GNRMEFLYHV2324 GYILTSVLGL2334 FAHELFYSIL2344 LFDLIYREET 2354 LFNVIKSVTR2364 NGRSILLTAL2374 LALILVYLFS2384 IVGFLFLKDD2394 FILEVDRLST 2451 ERACDTLLMC2461 IVTVMNHGLR2471 NGGGVGDILR2481 KPSKDESLFP2491 ARVVYDLLFF 2501 FIVIIIVLNL2511 IFGVIIDTFA2521 DLRSEKQKKE2531 EILKTTCFIC2541 GLERDKFDNK 2551 TVSFEEHIKL2561 EHNMWNYLYF2571 IVLVRVKNKT2581 DYTGPESYVA2591 QMIKNKNLDW 2601 FPRMRAMSLV2611
|
|||||
|
|
||||||
| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
|---|---|
|
Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation
of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes
(Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors
of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information
(Front Pharmacol, 9, 1245, 2018;
Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
|
|
|
There is no similarity protein (E value < 0.005) for this target
|
|
Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
|
| KEGG Pathway | Pathway ID | Affiliated Target | Pathway Map |
|---|---|---|---|
| Calcium signaling pathway | hsa04020 | Affiliated Target |
|
| Class: Environmental Information Processing => Signal transduction | Pathway Hierarchy | ||
| cGMP-PKG signaling pathway | hsa04022 | Affiliated Target |
|
| Class: Environmental Information Processing => Signal transduction | Pathway Hierarchy | ||
| Phosphatidylinositol signaling system | hsa04070 | Affiliated Target |
|
| Class: Environmental Information Processing => Signal transduction | Pathway Hierarchy | ||
| Oocyte meiosis | hsa04114 | Affiliated Target |
|
| Class: Cellular Processes => Cell growth and death | Pathway Hierarchy | ||
| Apoptosis | hsa04210 | Affiliated Target |
|
| Class: Cellular Processes => Cell growth and death | Pathway Hierarchy | ||
| Cellular senescence | hsa04218 | Affiliated Target |
|
| Class: Cellular Processes => Cell growth and death | Pathway Hierarchy | ||
| Vascular smooth muscle contraction | hsa04270 | Affiliated Target |
|
| Class: Organismal Systems => Circulatory system | Pathway Hierarchy | ||
| Apelin signaling pathway | hsa04371 | Affiliated Target |
|
| Class: Environmental Information Processing => Signal transduction | Pathway Hierarchy | ||
| Gap junction | hsa04540 | Affiliated Target |
|
| Class: Cellular Processes => Cellular community - eukaryotes | Pathway Hierarchy | ||
| Platelet activation | hsa04611 | Affiliated Target |
|
| Class: Organismal Systems => Immune system | Pathway Hierarchy | ||
| NOD-like receptor signaling pathway | hsa04621 | Affiliated Target |
|
| Class: Organismal Systems => Immune system | Pathway Hierarchy | ||
| C-type lectin receptor signaling pathway | hsa04625 | Affiliated Target |
|
| Class: Organismal Systems => Immune system | Pathway Hierarchy | ||
| Circadian entrainment | hsa04713 | Affiliated Target |
|
| Class: Organismal Systems => Environmental adaptation | Pathway Hierarchy | ||
| Long-term potentiation | hsa04720 | Affiliated Target |
|
| Class: Organismal Systems => Nervous system | Pathway Hierarchy | ||
| Retrograde endocannabinoid signaling | hsa04723 | Affiliated Target |
|
| Class: Organismal Systems => Nervous system | Pathway Hierarchy | ||
| Glutamatergic synapse | hsa04724 | Affiliated Target |
|
| Class: Organismal Systems => Nervous system | Pathway Hierarchy | ||
| Cholinergic synapse | hsa04725 | Affiliated Target |
|
| Class: Organismal Systems => Nervous system | Pathway Hierarchy | ||
| Serotonergic synapse | hsa04726 | Affiliated Target |
|
| Class: Organismal Systems => Nervous system | Pathway Hierarchy | ||
| Dopaminergic synapse | hsa04728 | Affiliated Target |
|
| Class: Organismal Systems => Nervous system | Pathway Hierarchy | ||
| Long-term depression | hsa04730 | Affiliated Target |
|
| Class: Organismal Systems => Nervous system | Pathway Hierarchy | ||
| Taste transduction | hsa04742 | Affiliated Target |
|
| Class: Organismal Systems => Sensory system | Pathway Hierarchy | ||
| Inflammatory mediator regulation of TRP channels | hsa04750 | Affiliated Target |
|
| Class: Organismal Systems => Sensory system | Pathway Hierarchy | ||
| Insulin secretion | hsa04911 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| GnRH signaling pathway | hsa04912 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| Estrogen signaling pathway | hsa04915 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| Thyroid hormone synthesis | hsa04918 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| Oxytocin signaling pathway | hsa04921 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| Glucagon signaling pathway | hsa04922 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| Renin secretion | hsa04924 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| Aldosterone synthesis and secretion | hsa04925 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| Cortisol synthesis and secretion | hsa04927 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| Parathyroid hormone synthesis, secretion and action | hsa04928 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| GnRH secretion | hsa04929 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| Growth hormone synthesis, secretion and action | hsa04935 | Affiliated Target |
|
| Class: Organismal Systems => Endocrine system | Pathway Hierarchy | ||
| Salivary secretion | hsa04970 | Affiliated Target |
|
| Class: Organismal Systems => Digestive system | Pathway Hierarchy | ||
| Gastric acid secretion | hsa04971 | Affiliated Target |
|
| Class: Organismal Systems => Digestive system | Pathway Hierarchy | ||
| Pancreatic secretion | hsa04972 | Affiliated Target |
|
| Class: Organismal Systems => Digestive system | Pathway Hierarchy | ||
| Click to Show/Hide the Information of Affiliated Human Pathways | |||
| Degree | 8 | Degree centrality | 8.59E-04 | Betweenness centrality | 5.60E-04 |
|---|---|---|---|---|---|
| Closeness centrality | 2.33E-01 | Radiality | 1.41E+01 | Clustering coefficient | 7.14E-02 |
| Neighborhood connectivity | 3.94E+01 | Topological coefficient | 1.38E-01 | Eccentricity | 11 |
| Download | Click to Download the Full PPI Network of This Target | ||||
| Chemical Structure based Activity Landscape of Target | Top |
|---|---|
| Target Regulators | Top | |||||
|---|---|---|---|---|---|---|
| Target-interacting Proteins | ||||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 745). | |||||
| REF 2 | Structural basis for activation and gating of IP(3) receptors. Nat Commun. 2022 Mar 17;13(1):1408. | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.