Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T12581 | Target Info | |||
Target Name | IP3 receptor isoform 3 (ITPR3) | ||||
Synonyms | Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor; InsP3R3; Inositol 1,4,5-trisphosphate receptor type 3; IP3R 3 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | ITPR3 | ||||
Biochemical Class | Ryanodine-inositol triphosphate calcium channel | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Adenosine triphosphate | Ligand Info | |||||
Structure Description | IP3, ATP, and Ca2+ bound type 3 IP3 receptor in the inactive state | PDB:7T3U | ||||
Method | Electron microscopy | Resolution | 3.70 Å | Mutation | No | [1] |
PDB Sequence |
SSFLHIGDIV
14 SLYAEGSVNG24 FISTLGLVDD34 RCVVEPAAGD44 LDNPPKKFRD54 CLFKVCPMNR 64 YSAQKQYWKA74 KQTDVVLLQK92 LQHAAQMEQK102 QNDTENKKVH112 GDVVKYGSVI 122 QLLHMKSNKY132 LTVNKRLPAL142 LEKNAMRVTL152 DATGNEGSWL162 FIQPFWKLRS 172 NGDNVVVGDK182 VILNPVNAGQ192 PLHASNYELS202 DNAGCKEVNS212 VNCNTSWKIN 222 LFMQFVLKGG238 DVVRLFHAEQ248 EKFLTCDEYK258 GKLQVFLRTT268 LRQSATSATS 278 SNALWEVEVV288 HLYRFKHLAT311 GNYLAAEENK351 YCLVAVPHGN361 DIASLFELDP 371 TYVRLRHLCT394 NTWIQSTNVP404 IDIEEERPIR414 LMLGTCPTKE424 DKEAFAIVSV 434 PVSEIRDLDF444 ANDASSMLAS454 AVEKLNEGFI464 SQNDRRFVIQ474 LLEDLVFFVS 484 DVPNNGQNVL494 DIMVTKPNRE504 RQKLMREQNI514 LKQVFGILKA524 PFRPLVRLEE 540 LSDQKNAPYQ550 HMFRLCYRVL560 RHSQEDYRKN570 QEHIAKQFGM580 MQSQIGYDIL 590 AEDTITALLH600 NNRKLLEKHI610 TKTEVETFVS620 LVRKNREPRF630 LDYLSDLCVS 640 NHIAIPVTQE650 LICKCVLDPK660 NSDILIRTEL670 RPEVWLTWTD698 KNNEHHEKSV 708 RQLAQEARAG718 NAHDENVLSY728 YRYQLKLFAR738 MCLDRQYLAI748 DEISQQLGVD 758 LIFLCMADEM768 LPFDLRASFC778 HLMLHVHVDR788 DPQELVTPVK798 FARLWTEIPT 808 AITIKDYDSN818 LNNKFANTME835 FVEDYLNNVV845 SEAVPFANEE855 KNKLTFEVVS 865 LAHNLIYFGF875 YSFSELLRLT885 RTLLGIIDCD961 IVVMETKLKI971 LEILQFILNV 981 RLDYRISYLL991 SVFKKEFLDR1027 IGEQAEAMFG1037 SMLEVDDEGG1052 RMFLRVLIHL 1062 TMHDYAPLVS1072 GALQLLFKHF1082 SQRQEAMHTF1092 KQVQLLISAQ1102 DVENYKVIKS 1112 ELDRLRTMVE1122 KNYQIVKGIL1176 ERLNKMCQMR1190 KKQQRLLKNM1200 DAHKVMLDLL 1210 QIPYDKGDAK1220 MMEILRYTHQ1230 FLQKFCAGNP1240 GNQALLHKHL1250 HLFLTPGLLE 1260 AETMQHIFLN1270 NYQLCSEISE1280 PVLQHFVHLL1290 ATHGRHVQYL1300 DFLHTVIKAD 1319 MIMTELTNAG1329 DDVVVFYNDK1339 ASLAHLLDMM1349 KAARDGVEDH1359 SPLMYHISLV 1369 DLLAACAEGK1379 NVYTEIKCTS1389 LLPLEDVVSV1399 VTHEDCITEV1409 KMAYVNFVNH 1436 IWTLFENFTL1446 DMARVCSDPT1463 LEKYVLSVVL1473 DTINAFFSSP1483 FSENSTSLQT 1493 HQTIVVQLLQ1503 STTRLLECPW1513 LQQQHKGSVE1523 ACIRTLAMVK1589 NIIEKLQDII 1599 TALEERLKPL1609 VQAELSVLVD1619 VLHWPELLFL1629 EGSEAYQRCE1639 SGGFLSKLIQ 1649 HTKDLMESEE1659 KLCIKVLRTL1669 QQMLLKKTKY1679 GDRGNQLRKM1689 LLQNYLQSAI 1721 AATQCRLDKE1731 GATKLVCDLI1741 TSTKNEKIFQ1751 ESIGLAIHLL1761 DGGNTEIQKS 1771 FHNLMMSDKK1781 SERFFKVLHD1791 RMKRAQQETT1865 SVLIMQPILR1875 FLQLLCENHN 1885 RDLQNFLRCQ1895 NNKTNYNLVC1905 ETLQFLDIGL1924 LGLYINEDNV1934 GLVIQTLETL 1944 TEYCQGPCHE1954 NQTCIVTHES1964 NGIDIITALI1974 LNDLVLQLKD1994 NASKLLLALM 2004 ESNAERILIS2019 LRPQELVDVI2029 KKAYLVSPRE2048 VGHNIYILAL2058 QLSRHNKQLQ 2068 HLLKPDPLAY2116 YENHTSQIEI2126 VRQDRSMEQI2136 VFPVPGICQF2146 LTEETKHRLF 2156 TTTEQDEQGS2166 KVSDFFDQSS2176 FLHNEMEWQR2186 KLRSMPLIYW2196 FSRRMTLWGS 2206 ISFNLAVFIN2216 IIIAFFYPYI2261 RPLIVALILR2271 SIYYLGIGPT2281 LNILGALNLT 2291 NKIVFVVSFV2301 GNRMEFLYHV2324 GYILTSVLGL2334 FAHELFYSIL2344 LFDLIYREET 2354 LFNVIKSVTR2364 NGRSILLTAL2374 LALILVYLFS2384 IVGFLFLKDD2394 FILEVDRLST 2451 ERACDTLLMC2461 IVTVMNHGLR2471 NGGGVGDILR2481 KPSKDESLFP2491 ARVVYDLLFF 2501 FIVIIIVLNL2511 IFGVIIDTFA2521 DLRSEKQKKE2531 EILKTTCFIC2541 GLERDKFDNK 2551 TVSFEEHIKL2561 EHNMWNYLYF2571 IVLVRVKNKT2581 DYTGPESYVA2591 QMIKNKNLDW 2601 FPRMRAMSLV2611
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Ligand Name: D-myo-inositol 1,4,5-trisphosphate | Ligand Info | |||||
Structure Description | IP3, ATP, and Ca2+ bound type 3 IP3 receptor in the inactive state | PDB:7T3U | ||||
Method | Electron microscopy | Resolution | 3.70 Å | Mutation | No | [1] |
PDB Sequence |
SSFLHIGDIV
14 SLYAEGSVNG24 FISTLGLVDD34 RCVVEPAAGD44 LDNPPKKFRD54 CLFKVCPMNR 64 YSAQKQYWKA74 KQTDVVLLQK92 LQHAAQMEQK102 QNDTENKKVH112 GDVVKYGSVI 122 QLLHMKSNKY132 LTVNKRLPAL142 LEKNAMRVTL152 DATGNEGSWL162 FIQPFWKLRS 172 NGDNVVVGDK182 VILNPVNAGQ192 PLHASNYELS202 DNAGCKEVNS212 VNCNTSWKIN 222 LFMQFVLKGG238 DVVRLFHAEQ248 EKFLTCDEYK258 GKLQVFLRTT268 LRQSATSATS 278 SNALWEVEVV288 HLYRFKHLAT311 GNYLAAEENK351 YCLVAVPHGN361 DIASLFELDP 371 TYVRLRHLCT394 NTWIQSTNVP404 IDIEEERPIR414 LMLGTCPTKE424 DKEAFAIVSV 434 PVSEIRDLDF444 ANDASSMLAS454 AVEKLNEGFI464 SQNDRRFVIQ474 LLEDLVFFVS 484 DVPNNGQNVL494 DIMVTKPNRE504 RQKLMREQNI514 LKQVFGILKA524 PFRPLVRLEE 540 LSDQKNAPYQ550 HMFRLCYRVL560 RHSQEDYRKN570 QEHIAKQFGM580 MQSQIGYDIL 590 AEDTITALLH600 NNRKLLEKHI610 TKTEVETFVS620 LVRKNREPRF630 LDYLSDLCVS 640 NHIAIPVTQE650 LICKCVLDPK660 NSDILIRTEL670 RPEVWLTWTD698 KNNEHHEKSV 708 RQLAQEARAG718 NAHDENVLSY728 YRYQLKLFAR738 MCLDRQYLAI748 DEISQQLGVD 758 LIFLCMADEM768 LPFDLRASFC778 HLMLHVHVDR788 DPQELVTPVK798 FARLWTEIPT 808 AITIKDYDSN818 LNNKFANTME835 FVEDYLNNVV845 SEAVPFANEE855 KNKLTFEVVS 865 LAHNLIYFGF875 YSFSELLRLT885 RTLLGIIDCD961 IVVMETKLKI971 LEILQFILNV 981 RLDYRISYLL991 SVFKKEFLDR1027 IGEQAEAMFG1037 SMLEVDDEGG1052 RMFLRVLIHL 1062 TMHDYAPLVS1072 GALQLLFKHF1082 SQRQEAMHTF1092 KQVQLLISAQ1102 DVENYKVIKS 1112 ELDRLRTMVE1122 KNYQIVKGIL1176 ERLNKMCQMR1190 KKQQRLLKNM1200 DAHKVMLDLL 1210 QIPYDKGDAK1220 MMEILRYTHQ1230 FLQKFCAGNP1240 GNQALLHKHL1250 HLFLTPGLLE 1260 AETMQHIFLN1270 NYQLCSEISE1280 PVLQHFVHLL1290 ATHGRHVQYL1300 DFLHTVIKAD 1319 MIMTELTNAG1329 DDVVVFYNDK1339 ASLAHLLDMM1349 KAARDGVEDH1359 SPLMYHISLV 1369 DLLAACAEGK1379 NVYTEIKCTS1389 LLPLEDVVSV1399 VTHEDCITEV1409 KMAYVNFVNH 1436 IWTLFENFTL1446 DMARVCSDPT1463 LEKYVLSVVL1473 DTINAFFSSP1483 FSENSTSLQT 1493 HQTIVVQLLQ1503 STTRLLECPW1513 LQQQHKGSVE1523 ACIRTLAMVK1589 NIIEKLQDII 1599 TALEERLKPL1609 VQAELSVLVD1619 VLHWPELLFL1629 EGSEAYQRCE1639 SGGFLSKLIQ 1649 HTKDLMESEE1659 KLCIKVLRTL1669 QQMLLKKTKY1679 GDRGNQLRKM1689 LLQNYLQSAI 1721 AATQCRLDKE1731 GATKLVCDLI1741 TSTKNEKIFQ1751 ESIGLAIHLL1761 DGGNTEIQKS 1771 FHNLMMSDKK1781 SERFFKVLHD1791 RMKRAQQETT1865 SVLIMQPILR1875 FLQLLCENHN 1885 RDLQNFLRCQ1895 NNKTNYNLVC1905 ETLQFLDIGL1924 LGLYINEDNV1934 GLVIQTLETL 1944 TEYCQGPCHE1954 NQTCIVTHES1964 NGIDIITALI1974 LNDLVLQLKD1994 NASKLLLALM 2004 ESNAERILIS2019 LRPQELVDVI2029 KKAYLVSPRE2048 VGHNIYILAL2058 QLSRHNKQLQ 2068 HLLKPDPLAY2116 YENHTSQIEI2126 VRQDRSMEQI2136 VFPVPGICQF2146 LTEETKHRLF 2156 TTTEQDEQGS2166 KVSDFFDQSS2176 FLHNEMEWQR2186 KLRSMPLIYW2196 FSRRMTLWGS 2206 ISFNLAVFIN2216 IIIAFFYPYI2261 RPLIVALILR2271 SIYYLGIGPT2281 LNILGALNLT 2291 NKIVFVVSFV2301 GNRMEFLYHV2324 GYILTSVLGL2334 FAHELFYSIL2344 LFDLIYREET 2354 LFNVIKSVTR2364 NGRSILLTAL2374 LALILVYLFS2384 IVGFLFLKDD2394 FILEVDRLST 2451 ERACDTLLMC2461 IVTVMNHGLR2471 NGGGVGDILR2481 KPSKDESLFP2491 ARVVYDLLFF 2501 FIVIIIVLNL2511 IFGVIIDTFA2521 DLRSEKQKKE2531 EILKTTCFIC2541 GLERDKFDNK 2551 TVSFEEHIKL2561 EHNMWNYLYF2571 IVLVRVKNKT2581 DYTGPESYVA2591 QMIKNKNLDW 2601 FPRMRAMSLV2611
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References | Top | ||||
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REF 1 | Structural basis for activation and gating of IP(3) receptors. Nat Commun. 2022 Mar 17;13(1):1408. |
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