| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T98913 | ||||
| Target Name | Granulocyte colony-stimulating factor receptor (G-CSF-R) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Midostaurin | Drug Info | IC50 = 142 nM | [3] | |
| N-(2-morpholinophenyl)-5-nitrofuran-2-carboxamide | Drug Info | IC50 = 1100 nM | [2] | ||
| Tandutinib | Drug Info | IC50 = 3430 nM | [1] | ||
| References | |||||
| REF 1 | Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyro... J Med Chem. 2002 Aug 15;45(17):3772-93. | ||||
| REF 2 | Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6070-4. | ||||
| REF 3 | Colony stimulating factor-1 receptor as a target for small molecule inhibitors. Bioorg Med Chem. 2010 Mar 1;18(5):1789-97. | ||||
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