Target Validation Information
TTD ID	T81100
Target Name	SLC5A2 messenger RNA (SLC5A2 mRNA)
Type of Target	Successful
Drug Potency against Target	KURARINONE	Drug Info	IC50 = 1700 nM	[1]
	O-spiroketal glucoside	Drug Info	IC50 = 6.5 nM	[3]
	SERGLIFLOZIN A	Drug Info	IC50 = 6.25 nM	[2]
	Sophoraflavanone G	Drug Info	IC50 = 4100 nM	[1]
References
REF 1	Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.
REF 2	Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: 1,3,4-Thiadiazolylmethylphenyl glucoside congeners. Bioorg Med Chem. 2010 Mar 15;18(6):2178-2194.
REF 3	ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Bioorg Med Chem. 2010 Jun 15;18(12):4422-32.

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