Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01PNM
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| Former ID |
DNC007647
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| Drug Name |
KURARINONE
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| Synonyms |
(-)-kurarinone; Kurarinone; CHEMBL243796; SCHEMBL10307523; BDBM50208612
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C26H30O6
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| Canonical SMILES |
CC(=CCC(CC1=C2C(=C(C=C1O)OC)C(=O)CC(O2)C3=C(C=C(C=C3)O)O)C(=C)C)C
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| InChI |
1S/C26H30O6/c1-14(2)6-7-16(15(3)4)10-19-21(29)12-24(31-5)25-22(30)13-23(32-26(19)25)18-9-8-17(27)11-20(18)28/h6,8-9,11-12,16,23,27-29H,3,7,10,13H2,1-2,4-5H3/t16-,23+/m1/s1
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| InChIKey |
LTTQKYMNTNISSZ-MWTRTKDXSA-N
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| CAS Number |
CAS 34981-26-5
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:66150
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Beta-secretase (BACE) | Target Info | Inhibitor | [2] |
| SLC5A2 messenger RNA (SLC5A2 mRNA) | Target Info | Inhibitor | [1] | |
| Sodium/glucose cotransporter 1 (SGLT1) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Carbohydrate digestion and absorption | |||
| Bile secretion | ||||
| Mineral absorption | ||||
| Pathwhiz Pathway | Lactose Degradation | |||
| Trehalose Degradation | ||||
| Reactome | Hexose transport | |||
| Na+-dependent glucose transporters | ||||
| Inositol transporters | ||||
| WikiPathways | NRF2 pathway | |||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| Metabolism of carbohydrates | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. | |||
| REF 2 | BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens. Bioorg Med Chem. 2008 Jul 15;16(14):6669-74. | |||
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