Target Validation Information | |||||
---|---|---|---|---|---|
TTD ID | T80975 | ||||
Target Name | Vascular endothelial growth factor receptor 2 (KDR) | ||||
Type of Target |
Successful |
||||
Drug Potency against Target | Sunitinib | Drug Info | Ki = 80 nM | [43] | |
Axitinib | Drug Info | IC50 = 0.2 nM | [42] | ||
BAY-57-9352 | Drug Info | Ki = 6 nM | [44] | ||
Cediranib | Drug Info | IC50 < 1 nM | [37] | ||
CEP-11981 | Drug Info | Ki = 18 nM | [34] | ||
CP-547632 | Drug Info | IC50 = 11 nM | [33] | ||
KRN633 | Drug Info | IC50 = 1.16 nM | [9] | ||
Motesanib | Drug Info | Ki = 3 nM | [36] | ||
OSI-930 | Drug Info | Ki = 9 nM | [35] | ||
Rosiglitazone + metformin | Drug Info | Ki = 2100 nM | [32] | ||
SU-14813 | Drug Info | IC50 = 50 nM | [38] | ||
Vandetanib | Drug Info | IC50 = 40 nM | [40] | ||
VATALANIB | Drug Info | IC50 = 30 nM | [41] | ||
XL880 | Drug Info | Ki = 0.86 nM | [45] | ||
(2-Methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine | Drug Info | IC50 = 3260 nM | [10] | ||
(3-Phenoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine | Drug Info | IC50 = 1410 nM | [10] | ||
(4-Phenoxy-phenyl)-quinazolin-4-yl-amine | Drug Info | IC50 = 2720 nM | [1] | ||
(5-Phenyl-oxazol-2-yl)-m-tolyl-amine | Drug Info | IC50 = 1700 nM | [10] | ||
2-(1H-indazol-3-yl)-1H-benzo[d]imidazole | Drug Info | IC50 = 3300 nM | [18] | ||
2-(5-Phenyl-oxazol-2-ylamino)-benzonitrile | Drug Info | IC50 = 14400 nM | [10] | ||
2-(p-toluidino)-4-phenylpyrimidine-5-carbonitrile | Drug Info | IC50 = 1000 nM | [27] | ||
2-(pyrimidin-4-ylamino)thiazole-5-carbonitrile | Drug Info | IC50 = 990 nM | [15] | ||
3,6-Di-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine | Drug Info | IC50 = 224 nM | [2] | ||
3-((3-bromothiophen-2-yl)methylene)indolin-2-one | Drug Info | IC50 = 15400 nM | [23] | ||
3-(1H-Indol-2-yl)-1H-quinolin-2-one | Drug Info | IC50 = 8 nM | [6] | ||
3-(4-aminophenyl)thieno[3,2-c]pyridin-4-amine | Drug Info | IC50 = 4900 nM | [22] | ||
3-(5-Phenyl-oxazol-2-ylamino)-benzonitrile | Drug Info | IC50 = 7600 nM | [10] | ||
3-(5-Thiophen-3-yl-pyridin-3-yl)-1H-indole | Drug Info | IC50 = 126 nM | [5] | ||
3-Benzimidazol-2-ylhydroquinolin-2-one | Drug Info | IC50 = 1700 nM | [30] | ||
3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide | Drug Info | IC50 = 17000 nM | [13] | ||
3-phenyl-1,4-dihydroindeno[1,2-c]pyrazole | Drug Info | IC50 = 1200 nM | [19] | ||
4-(4-aminophenyl)-1H-indazol-3yl-amine | Drug Info | IC50 = 4790 nM | [24] | ||
4-(4-m-Tolylamino-phthalazin-1-yl)-benzamide | Drug Info | IC50 = 1600 nM | [12] | ||
4-(4-p-Tolylamino-phthalazin-1-yl)-benzamide | Drug Info | IC50 = 1800 nM | [12] | ||
4-(5-Phenyl-oxazol-2-ylamino)-benzenesulfonamide | Drug Info | IC50 = 4660 nM | [10] | ||
4-Chloro-N-(2-chloro-benzoyl)-benzenesulfonamide | Drug Info | IC50 = 14000 nM | [8] | ||
4-Chloro-N-(2-methyl-benzoyl)-benzenesulfonamide | Drug Info | IC50 = 15000 nM | [8] | ||
4-Chloro-N-(3-chloro-benzoyl)-benzenesulfonamide | Drug Info | IC50 = 14000 nM | [8] | ||
4-Chloro-N-(4-chloro-benzoyl)-benzenesulfonamide | Drug Info | IC50 = 6300 nM | [8] | ||
4-Chloro-N-(4-nitro-benzoyl)-benzenesulfonamide | Drug Info | IC50 = 11000 nM | [8] | ||
4-phenyl-2-(phenylamino)pyrimidine-5-carbonitrile | Drug Info | IC50 = 1000 nM | [27] | ||
4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline | Drug Info | IC50 = 50 nM | [23] | ||
5-(4-Methoxy-phenyl)-1-phenyl-1H-benzoimidazole | Drug Info | IC50 = 113 nM | [4] | ||
6-(1H-Benzoimidazol-2-yl)-benzocyclohepten-7-one | Drug Info | IC50 = 355 nM | [6] | ||
6-o-tolylquinazolin-2-amine | Drug Info | IC50 = 4966 nM | [20] | ||
8-methyl-4H,7H-indolo[6,5,4-cd]indol-5-one | Drug Info | IC50 = 1000 nM | [23] | ||
AG1295 | Drug Info | IC50 = 6200 nM | [31] | ||
AZD-1152-HQPA | Drug Info | Ki = 1800 nM | [25] | ||
BMS-536924 | Drug Info | IC50 = 1400 nM | [11] | ||
BMS-645737 | Drug Info | IC50 = 53 nM | [28] | ||
Brivanib | Drug Info | Ki = 28 nM | [17] | ||
CB-676475 | Drug Info | IC50 = 1000 nM | [14] | ||
CEP-5104 | Drug Info | IC50 = 4175 nM | [29] | ||
HKI-272 | Drug Info | IC50 = 858.2 nM | [26] | ||
IM-023911 | Drug Info | IC50 = 190 nM | [12] | ||
Isoindolinone Urea derivative | Drug Info | IC50 = 18 nM | [7] | ||
L000021649 | Drug Info | IC50 = 3 nM | [2] | ||
N-(2,4-Dichloro-benzoyl)-benzenesulfonamide | Drug Info | IC50 = 530 nM | [8] | ||
N-(3-Bromo-benzoyl)-4-chloro-benzenesulfonamide | Drug Info | IC50 = 15000 nM | [8] | ||
PD-153035 | Drug Info | IC50 = 1489 nM | [26] | ||
Phenyl-(5-phenyl-oxazol-2-yl)-amine | Drug Info | IC50 = 3000 nM | [10] | ||
Ro-4396686 | Drug Info | IC50 = 50 nM | [16] | ||
SU-11652 | Drug Info | IC50 = 50 nM | [3] | ||
TG-100435 | Drug Info | Ki = 784 nM | [21] | ||
VATALANIB | Drug Info | IC50 = 6754 nM | [26] | ||
[3-(5-Phenyl-oxazol-2-ylamino)-phenyl]-methanol | Drug Info | IC50 = 1650 nM | [10] | ||
Action against Disease Model | Sunitinib | Drug Info | In nine h uMan AML cell lines, sunitinib were potent inhibitor of cellular proliferation (IC50: 7~13,000 nM/L) | [39] | |
References | |||||
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