Target Validation Information
TTD ID	T05114
Target Name	Chymase (CYM)
Type of Target	Clinical trial
Drug Potency against Target	BOCEPREVIR	Drug Info	IC50 = 32 nM	[4]
	CHYMOSTATIN	Drug Info	IC50 = 43 nM	[2]
	Delanzomib	Drug Info	IC50 = 3530 nM	[3]
	JNJ-10311795	Drug Info	Ki = 2.3 nM	[1]
	Rac-2q	Drug Info	IC50 = 39 nM	[2]
References
REF 1	Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30.
REF 2	Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3431-4.
REF 3	Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer. J Med Chem. 2008 Feb 28;51(4):1068-72.
REF 4	MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrob Agents Chemother. 2010 Jan;54(1):305-11.

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