Drug Information
Drug General Information | Top | |||
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Drug ID |
D0C8UF
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Former ID |
DNC007964
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Drug Name |
Rac-2q
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Synonyms |
CHEMBL246964; rac-2q; SCHEMBL1186511; MZKGVXPHEXNJSG-UHFFFAOYSA-N; BDBM50210099; [4-chloro-2-({1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl}methyl)phenoxy]acetic acid
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C20H18Cl2N2O7S
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Canonical SMILES |
C1C(C(=O)N(CC(=O)N1)S(=O)(=O)C2=CC=C(C=C2)Cl)CC3=C(C=CC(=C3)Cl)OCC(=O)O
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InChI |
1S/C20H18Cl2N2O7S/c21-14-1-4-16(5-2-14)32(29,30)24-10-18(25)23-9-13(20(24)28)7-12-8-15(22)3-6-17(12)31-11-19(26)27/h1-6,8,13H,7,9-11H2,(H,23,25)(H,26,27)
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InChIKey |
MZKGVXPHEXNJSG-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Chymase (CYM) | Target Info | Inhibitor | [1] |
KEGG Pathway | Renin-angiotensin system | |||
Reactome | Activation of Matrix Metalloproteinases | |||
Metabolism of Angiotensinogen to Angiotensins | ||||
WikiPathways | ACE Inhibitor Pathway | |||
Metabolism of Angiotensinogen to Angiotensins |
References | Top | |||
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REF 1 | Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3431-4. |
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