Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T91696 Target Info
Target Name Fibronectin (FN1)
Synonyms FN; Cold-insoluble globulin; CIG
Target Type Clinical trial Target
Gene Name FN1
Biochemical Class Fibronectin protein
UniProt ID
FINC_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Myosin-9 (MYH9) Interacting Protein Interacting Protein Info
UniProt ID
MYH9_HUMAN 
Synonyms BDPLT6; DFNA17; EPSTS; FTNS; MHA; NMHC.II.A; NMMHC.IIA; NMMHCA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [2]
Integrins [+] 2 Integrins +
Interacting Target Name Integrin alpha-5 (ITGA5) Clinical trial Target Interacting Protein Info
UniProt ID
ITA5_HUMAN 
Synonyms VLA-5; Integrin alpha-F; Integrin alpha-5 light chain; Integrin alpha-5 heavy chain; FNRA; Fibronectin receptor subunit alpha; CD49e antigen; CD49e; CD49 antigen-like family member E
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
5 Reconstituted Complex [5]
Interacting Target Name Integrin beta-1 (ITGB1) Clinical trial Target Interacting Protein Info
UniProt ID
ITB1_HUMAN 
Synonyms VLA-4 subunit beta; MSK12; MDF2; Integrin VLA-4 beta subunit; GPIIA; Glycoprotein IIa; FNRB; Fibronectin receptor subunit beta; Fibronectin receptor beta subunit; CD29 antigen; CD29; Beta(1) integrin
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Reconstituted Complex [5]
4 Reconstituted Complex [4]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Protein Name Importin subunit alpha-1 (KPNA2) Interacting Protein Interacting Protein Info
UniProt ID
IMA1_HUMAN 
Synonyms IPOA1; QIP2; RCH1; SRP1alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [6]
Other proteins [+] 3 Other proteins +
Interacting Target Name Insulin-like growth factor-binding protein 3 (IGFBP3) Clinical trial Target Interacting Protein Info
UniProt ID
IBP3_HUMAN 
Synonyms IGFBP-3; IGF-binding protein 3; IBP-3; IBP3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [8]
3 Yeast two hybrid [7]
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [10]
Interacting Target Name Apoptosis antigen ligand (CD178) Literature-reported Target Interacting Protein Info
UniProt ID
TNFL6_HUMAN 
Synonyms Tumor necrosis factor ligand superfamily member 6; TNFSF6; FasL; Fas ligand; FAS antigen ligand; CD95-L; CD95L; CD95 ligand; CD178 antigen; CD178; APTL; APT1LG1; Apoptosis antigen ligand
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [11]
2 Reconstituted Complex [12]
References  Top
REF 1 Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal. 2009 Sep 8;2(87):ra51.
REF 2 Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry. J Proteome Res. 2013 Jul 5;12(7):3393-404.
REF 3 Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. J Biol Chem. 1992 Mar 25;267(9):5790-6.
REF 4 Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with 51 integrin. J Biol Chem. 2014 Nov 7;289(45):31330-40.
REF 5 Interplay of Endosomal pH and Ligand Occupancy in Integrin 51Ubiquitination, Endocytic Sorting, and Cell Migration. Cell Rep. 2015 Oct 20;13(3):599-609.
REF 6 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 7 Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma. J Clin Endocrinol Metab. 2001 May;86(5):2104-10.
REF 8 Co-localization of insulin-like growth factor binding protein 3 and fibronectin in human articular cartilage. Osteoarthritis Cartilage. 2002 Jul;10(7):556-63.
REF 9 Proteomic dissection of the von Hippel-Lindau (VHL) interactome. J Proteome Res. 2011 Nov 4;10(11):5175-82.
REF 10 The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell. 1998 Jun;1(7):959-68.
REF 11 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 12 Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity. Nat Immunol. 2001 Apr;2(4):333-7.

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