Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T86350 Target Info
Target Name Erbb3 tyrosine kinase receptor (Erbb-3)
Synonyms Tyrosine kinase-type cell surface receptor HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3; C-erbB3; C-erbB-3 protein
Target Type Clinical trial Target
Gene Name ERBB3
Biochemical Class Kinase
UniProt ID
ERBB3_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Interacting Protein Name Growth factor receptor-bound protein 7 (GRB7) Interacting Protein Interacting Protein Info
UniProt ID
GRB7_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Protein-peptide [4]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Yeast two hybrid [5]
Kinases [+] 7 Kinases +
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [6]
3 Protein-peptide [4]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [7]
Interacting Target Name Erbb2 tyrosine kinase receptor (HER2) Successful Target Interacting Protein Info
UniProt ID
ERBB2_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER2; Tyrosine kinase receptor ErbB2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; P185erbB2; NGL; NEU proto-oncogene; NEU; MLN19; MLN 19; Metastatic lymph node gene 19 protein; HER2/neu; HER2 (erbB2/neu); HER-2; Erb2; Epidermal growth factor receptor 2; C-erbB-2 oncoprotein; C-erbB-2; CD340
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Co-localization [9]
Interacting Target Name PI3-kinase alpha (PIK3CA) Successful Target Interacting Protein Info
UniProt ID
PK3CA_HUMAN 
Synonyms Serine/threonine protein kinase PIK3CA; PtdIns-3-kinase subunit p110-alpha; PtdIns3kinase subunit p110alpha; PtdIns-3-kinase subunit alpha; PtdIns3kinase subunit alpha; PI3-kinase subunit alpha; PI3kinase subunit alpha; PI3K-alpha; PI3Kalpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Phosphoinositide3kinase catalytic alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalytic subunit alpha; p110alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [6]
Interacting Target Name Tyrosine-protein kinase BRK (PTK6) Clinical trial Target Interacting Protein Info
UniProt ID
PTK6_HUMAN 
Synonyms Tyrosine-protein kinase brk; PTK6; Brk (PTK6); BRK; Breast tumor kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Protein-peptide [4]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) Interacting Protein Interacting Protein Info
UniProt ID
P55G_HUMAN 
Synonyms p55; p55.GAMMA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Protein-peptide [4]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) Interacting Protein Interacting Protein Info
UniProt ID
P85B_HUMAN 
Synonyms MPPH; MPPH1; P85B; p85; p85.BETA
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Proliferation-associated protein 2G4 (PA2G4) Interacting Protein Interacting Protein Info
UniProt ID
PA2G4_HUMAN 
Synonyms EBP1; HG4.1; p38.2G4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [12]
Other proteins [+] 1 Other proteins +
Interacting Protein Name SHC-transforming protein 1 (SHC1) Interacting Protein Interacting Protein Info
UniProt ID
SHC1_HUMAN 
Synonyms SHC; SHCA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
3 Protein-peptide [4]
References  Top
REF 1 Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol. 2005;1:2005.0008.
REF 2 Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2. J Biol Chem. 1998 Oct 9;273(41):26954-61.
REF 3 Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Mol Syst Biol. 2013 Nov 5;9:705.
REF 4 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74.
REF 5 A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017 Jan 19;65(2):347-360.
REF 6 Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor. J Biol Chem. 2001 Nov 9;276(45):42153-61.
REF 7 Differential erbB signaling in astrocytes from the cerebral cortex and the hypothalamus of the human brain. Glia. 2009 Mar;57(4):362-79.
REF 8 Neuregulin-1 enhances survival of human astrocytic glioma cells. Glia. 2005 Aug 15;51(3):217-28.
REF 9 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 10 Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation. Oncogene. 2000 Nov 16;19(48):5471-6.
REF 11 Regulation of the ErbB3 binding protein Ebp1 by protein kinase C. Mol Cell Endocrinol. 2001 Apr 25;175(1-2):185-91.
REF 12 Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin. Br J Cancer. 2000 Feb;82(3):683-90.

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