Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T83585 Target Info
Target Name Wiskott-Aldrich syndrome protein (WAS)
Synonyms WASp; IMD2
Target Type Clinical trial Target
Gene Name WAS
UniProt ID
WASP_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Cell division control protein 42 homolog (CDC42) Interacting Protein Interacting Protein Info
UniProt ID
CDC42_HUMAN 
Synonyms CDC42Hs; G25K
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
5 Reconstituted Complex [5]
Adapter proteins [+] 3 Adapter proteins +
Interacting Target Name NCK adaptor protein 1 (NCK1) Clinical trial Target Interacting Protein Info
UniProt ID
NCK1_HUMAN 
Synonyms SH2/SH3 adaptor protein NCK-alpha; SH2/SH3 adaptor protein NCKalpha; Nck-1; Nck1; NCK; Cytoplasmic protein NCK1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [8]
4 Reconstituted Complex [8]
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Interacting Protein Name Cytoplasmic protein NCK2 (NCK2) Interacting Protein Interacting Protein Info
UniProt ID
NCK2_HUMAN 
Synonyms GRB4; NCKbeta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Yeast two hybrid [11]
Kinases [+] 5 Kinases +
Interacting Target Name Fyn tyrosine protein kinase (FYN) Successful Target Interacting Protein Info
UniProt ID
FYN_HUMAN 
Synonyms Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Fyn Protooncogene Syn; Fyn p59-Fyn
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Biochemical Activity [12]
3 Reconstituted Complex [13]
4 Reconstituted Complex [8]
Interacting Target Name Tyrosine-protein kinase BTK (ATK) Successful Target Interacting Protein Info
UniProt ID
BTK_HUMAN 
Synonyms Bruton's tyrosine kinase; Bruton tyrosine kinase; BPK; B-cell progenitor kinase; B cell progenitor kinase; AGMX1; Agammaglobulinemia tyrosine kinase; Agammaglobulinaemia tyrosine kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [15]
Interacting Target Name LCK tyrosine protein kinase (LCK) Successful Target Interacting Protein Info
UniProt ID
LCK_HUMAN 
Synonyms Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; p56-LCK; Lymphocyte cell-specific protein-tyrosine kinase; LSK; Leukocyte C-terminal Src kinase; LCK Protooncogene Syn; LCK p59-Fyn
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Biochemical Activity [17]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [10]
Interacting Target Name Tyrosine-protein kinase Fgr (FGR) Literature-reported Target Interacting Protein Info
UniProt ID
FGR_HUMAN 
Synonyms SRC2; Proto-oncogene c-Fgr; p58-Fgr; p58c-Fgr; p55-Fgr; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [10]
Other proteins [+] 2 Other proteins +
Interacting Protein Name WAS/WASL-interacting protein family member 1 (WIPF1) Interacting Protein Interacting Protein Info
UniProt ID
WIPF1_HUMAN 
Synonyms PRPL.2; WASPIP; WIP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Reconstituted Complex [18]
3 Yeast two hybrid [18]
4 Yeast two hybrid [11]
5 Yeast two hybrid [19]
Interacting Protein Name WAS/WASL-interacting protein family member 2 (WIPF2) Interacting Protein Interacting Protein Info
UniProt ID
WIPF2_HUMAN 
Synonyms WICH; WIRE
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Yeast two hybrid [19]
References  Top
REF 1 Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42. J Cell Sci. 2004 Apr 1;117(Pt 9):1835-47.
REF 2 Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature. 2000 Mar 9;404(6774):151-8.
REF 3 A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK. J Biol Chem. 2017 Jul 7;292(27):11361-11373.
REF 4 Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5615-8.
REF 5 Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell. 1996 Mar 8;84(5):723-34.
REF 6 Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J Cell Biol. 2000 Apr 3;149(1):181-94.
REF 7 Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics. Nat Commun. 2013;4:2863.
REF 8 Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains. Mol Cell Biol. 1995 Oct;15(10):5725-31.
REF 9 Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells. Mol Biol Cell. 1997 Sep;8(9):1709-21.
REF 10 Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases. Curr Biol. 1996 Aug 1;6(8):981-8.
REF 11 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 12 Sustained activation of N-WASP through phosphorylation is essential for neurite extension. Dev Cell. 2002 Nov;3(5):645-58.
REF 13 Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase. Mol Biol Rep. 1999 Aug;26(3):173-7.
REF 14 The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. Eur J Immunol. 1999 Jul;29(7):2269-79.
REF 15 Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. J Immunol. 1996 Nov 1;157(9):3791-5.
REF 16 A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions. Gene. 2005 Oct 10;359:18-25.
REF 17 Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J Biol Chem. 2006 Feb 10;281(6):3513-20.
REF 18 WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14671-6.
REF 19 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 20 The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. Exp Cell Res. 2002 Sep 10;279(1):21-33.

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