Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T77645 Target Info
Target Name TRAIL receptor 1 (TRAIL-R1)
Synonyms Tumor necrosis factor receptor superfamily member 10A; TRAILR1; TNF-related apoptosis-inducing ligand receptor 1; Death receptor 4; DR4; CD261; APO2
Target Type Clinical trial Target
Gene Name TNFRSF10A
Biochemical Class Cytokine receptor
UniProt ID
TR10A_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name FAS-associated death domain protein (FADD) Interacting Protein Interacting Protein Info
UniProt ID
FADD_HUMAN 
Synonyms MORT1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
Peptidases [+] 1 Peptidases +
Interacting Target Name Caspase-8 (CASP8) Patented-recorded Target Interacting Protein Info
UniProt ID
CASP8_HUMAN 
Synonyms MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [8]
5 Affinity Capture-Western [4]
6 Affinity Capture-Western [5]
7 Affinity Capture-Western [6]
8 Affinity Capture-Western [9]
9 Biochemical Activity [8]
Other proteins [+] 1 Other proteins +
Interacting Target Name TRAIL receptor 2 (TRAIL-R2) Clinical trial Target Interacting Protein Info
UniProt ID
TR10B_HUMAN 
Synonyms ZTNFR9; UNQ160/PRO186; Tumor necrosis factor receptor superfamily member 10B; TRICK2; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; KILLER; DR5; Death receptor 5; CD262
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [9]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity. 1997 Dec;7(6):821-30.
REF 3 Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism. J Biol Chem. 2004 Oct 1;279(40):41873-81.
REF 4 TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer. Mol Cell. 2012 Dec 28;48(6):888-99.
REF 5 USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability. Oncogene. 2017 Jan 26;36(4):458-470.
REF 6 Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. Blood. 2005 Feb 1;105(3):1246-55.
REF 7 Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem. 1997 Oct 10;272(41):25417-20.
REF 8 PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability. Cell Death Differ. 2009 Sep;16(9):1215-26.
REF 9 Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell. 2009 May 15;137(4):721-35.

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