Protein-Protein Interaction Details
Protein General Information | Top | ||||
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Full Name | FAS-associated death domain protein (FADD) | ||||
UniProt ID | FADD_HUMAN | ||||
Gene Name | FADD | ||||
Gene ID | 8772 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Clinical trial Target(s) | TRAIL receptor 1 (TRAIL-R1) | Target Info | PPI Info | [1] | |
TRAIL receptor 2 (TRAIL-R2) | Target Info | PPI Info | [1] | ||
Apoptosis mediating surface antigen FAS (FAS) | Target Info | PPI Info | [2] | ||
Receptor-interacting protein 1 (RIPK1) | Target Info | PPI Info | [3] | ||
Interacting Patented-recorded Target(s) | Caspase-8 (CASP8) | Target Info | PPI Info | [4] | |
Caspase-10 (CASP10) | Target Info | PPI Info | [5] | ||
Interacting Literature-reported Target(s) | CASP8-FADD-like regulator (CFLAR) | Target Info | PPI Info | [6] |
References | Top | ||||
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REF 1 | Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity. 1997 Dec;7(6):821-30. | ||||
REF 2 | The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. J Biol Chem. 2001 Jan 26;276(4):2668-77. | ||||
REF 3 | NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling. Cell Death Differ. 2009 Sep;16(9):1279-88. | ||||
REF 4 | ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature. 2009 Feb 12;457(7231):906-9. | ||||
REF 5 | Caspase-10 is an initiator caspase in death receptor signaling. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13884-8. | ||||
REF 6 | Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 1997 Jun;6(6):751-63. |
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