Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T70067 Target Info
Target Name TRAIL receptor 2 (TRAIL-R2)
Synonyms ZTNFR9; UNQ160/PRO186; Tumor necrosis factor receptor superfamily member 10B; TRICK2; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; KILLER; Death receptor 5; DR5; CD262
Target Type Clinical trial Target
Gene Name TNFRSF10B
Biochemical Class Cytokine receptor
UniProt ID
TR10B_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name FAS-associated death domain protein (FADD) Interacting Protein Interacting Protein Info
UniProt ID
FADD_HUMAN 
Synonyms MORT1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [7]
Peptidases [+] 1 Peptidases +
Interacting Target Name Caspase-8 (CASP8) Patented-recorded Target Interacting Protein Info
UniProt ID
CASP8_HUMAN 
Synonyms MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [4]
6 Affinity Capture-Western [5]
7 Affinity Capture-Western [6]
8 Affinity Capture-Western [7]
9 Biochemical Activity [9]
10 Co-purification [10]
Other proteins [+] 2 Other proteins +
Interacting Target Name TNF related apoptosis inducing ligand (TNFSF10) Clinical trial Target Interacting Protein Info
UniProt ID
TNF10_HUMAN 
Synonyms Tumor necrosis factor ligand superfamily member 10; TRAIL; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD253; Apo-2L; APO2L; Apo-2 ligand
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [12]
3 Co-crystal Structure [13]
4 Reconstituted Complex [14]
Interacting Target Name TRAIL receptor 1 (TRAIL-R1) Clinical trial Target Interacting Protein Info
UniProt ID
TR10A_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 10A; TRAILR1; TNF-related apoptosis-inducing ligand receptor 1; DR4; Death receptor 4; CD261; APO2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [7]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 3 Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity. 1997 Dec;7(6):821-30.
REF 4 TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer. Mol Cell. 2012 Dec 28;48(6):888-99.
REF 5 DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells. Mol Oncol. 2017 Dec;11(12):1733-1751.
REF 6 An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J Biol Chem. 2002 Jun 21;277(25):22320-9.
REF 7 Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. Blood. 2005 Feb 1;105(3):1246-55.
REF 8 Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem. 1997 Oct 10;272(41):25417-20.
REF 9 PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability. Cell Death Differ. 2009 Sep;16(9):1215-26.
REF 10 Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem. 2005 Mar 25;280(12):11641-7.
REF 11 TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 1997 Sep 1;16(17):5386-97.
REF 12 Identification of a novel pro-apoptotic role of NF-B in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. Oncogene. 2012 Mar 15;31(11):1468-74.
REF 13 Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol Cell. 1999 Oct;4(4):563-71.
REF 14 Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). FEBS Lett. 2000 Nov 24;485(2-3):135-41.

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