Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T47101 Target Info
Target Name Fibroblast growth factor receptor 1 (FGFR1)
Synonyms c-fgr; bFGF-R-1; bFGF-R; N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT2; FLT-2; FLG; FGFR-1; FGFBR; CEK; CD331 antigen; CD331; Basic fibroblast growth factor receptor 1; BFGFR
Target Type Successful Target
Gene Name FGFR1
Biochemical Class Kinase
UniProt ID
FGFR1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name E3 ubiquitin-protein ligase NEDD4 (NEDD4) Literature-reported Target Interacting Protein Info
UniProt ID
NEDD4_HUMAN 
Synonyms Neural precursor cell expressed developmentally down-regulated protein 4; NEDD4-1; NEDD-4; KIAA0093; HECT-type E3 ubiquitin transferase NEDD4; Cell proliferation-inducing gene 53 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Fibroblast growth factor receptor substrate 2 (FRS2) Interacting Protein Interacting Protein Info
UniProt ID
FRS2_HUMAN 
Synonyms FRS2A; FRS2alpha; SNT; SNT.1; SNT1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Biochemical Activity [5]
4 Co-crystal Structure [6]
5 Reconstituted Complex [7]
6 Reconstituted Complex [8]
7 Yeast two hybrid [8]
8 Yeast two hybrid [6]
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Target Name Fibroblast growth factor-2 (FGF2) Successful Target Interacting Protein Info
UniProt ID
FGF2_HUMAN 
Synonyms Prostatropin; Heparin-binding growth factor 2; HBGF-2; Fibroblast growth factor 2; FGFB; FGF-2; BFGF; Basic fibroblast growth factor
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Co-localization [11]
4 Protein-peptide [12]
5 Reconstituted Complex [13]
6 Reconstituted Complex [14]
7 Reconstituted Complex [15]
8 Reconstituted Complex [16]
9 Reconstituted Complex [17]
10 Reconstituted Complex [18]
11 Reconstituted Complex [19]
12 Reconstituted Complex [20]
13 Reconstituted Complex [21]
14 Reconstituted Complex [22]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Beta-klotho (KLB) Clinical trial Target Interacting Protein Info
UniProt ID
KLOTB_HUMAN 
Synonyms Klotho beta-like protein; BKL; BetaKlotho
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Fluorescence Resonance Energy Transfer [24]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Phospholipase C-gamma-1 (PLCG1) Interacting Protein Interacting Protein Info
UniProt ID
PLCG1_HUMAN 
Synonyms NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Affinity Capture-Western [4]
3 Biochemical Activity [26]
4 Co-crystal Structure [25]
5 Co-localization [27]
6 Fluorescence Resonance Energy Transfer [28]
7 Reconstituted Complex [26]
8 Yeast two hybrid [8]
9 Yeast two hybrid [29]
Growth factors [+] 2 Growth factors +
Interacting Target Name Heparin-binding growth factor 1 (FGF1) Clinical trial Target Interacting Protein Info
UniProt ID
FGF1_HUMAN 
Synonyms HBGF-1; Fibroblast growth factor 1; FGFA; FGF-1; Endothelial cell growth factor; ECGF-beta; ECGF; Beta-endothelial cell growth factor; AFGF; Acidic fibroblast growth factor
Evidence Score (E-score) 8 Experimental Evidences +
1 Protein-peptide [12]
2 Reconstituted Complex [30]
3 Reconstituted Complex [14]
4 Reconstituted Complex [15]
5 Reconstituted Complex [31]
6 Reconstituted Complex [16]
7 Reconstituted Complex [32]
8 Reconstituted Complex [17]
Interacting Target Name Fibroblast growth factor-8 (FGF8) Literature-reported Target Interacting Protein Info
UniProt ID
FGF8_HUMAN 
Synonyms Heparin-binding growth factor 8; HBGF-8; Fibroblast growth factor 8; FGF-8; Androgen-induced growth factor; AIGF
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [27]
2 Protein-peptide [12]
Kinases [+] 2 Kinases +
Interacting Target Name Ribosomal protein S6 kinase alpha-1 (RSK1) Patented-recorded Target Interacting Protein Info
UniProt ID
KS6A1_HUMAN 
Synonyms S6K-alpha-1; RSK-1; Ribosomal S6 kinase 1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; MAPKAPK1A; MAPKAP kinase 1a; MAPK-activated protein kinase 1a; MAP kinase-activated protein kinase 1a; 90 kDa ribosomal protein S6 kinase 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Reconstituted Complex [33]
3 Yeast two hybrid [29]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [27]
2 Reconstituted Complex [26]
3 Yeast two hybrid [29]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Co-localization [27]
3 Reconstituted Complex [33]
Other proteins [+] 5 Other proteins +
Interacting Target Name Neural cell adhesion molecule 1 (NCAM1) Clinical trial Target Interacting Protein Info
UniProt ID
NCAM1_HUMAN 
Synonyms neural cell adhesion molecule 1; N-CAM-1; NCAM-1; NCAM; MSK39; CD56
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Affinity Capture-Western [36]
3 Reconstituted Complex [32]
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Co-localization [27]
Interacting Target Name Extracellular matrix receptor III (CD44) Clinical trial Target Interacting Protein Info
UniProt ID
CD44_HUMAN 
Synonyms Phagocytic glycoprotein I; Phagocytic glycoprotein 1; PGP-I; PGP-1; MIC4; MDU3; MDU2; LHR; Hyaluronate receptor; HUTCH-I; Hermes antigen; Heparan sulfate proteoglycan; GP90 lymphocyte homing/adhesion receptor; Extracellular matrix receptor-III; Epican; ECMR-III; CDw44; CD44 antigen
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [38]
2 Affinity Capture-Western [39]
Interacting Target Name Proto-oncogene c-Crk (c-Crk) Literature-reported Target Interacting Protein Info
UniProt ID
CRK_HUMAN 
Synonyms P38; Adapter molecule crk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Co-localization [27]
Interacting Protein Name SHC-transforming protein 1 (SHC1) Interacting Protein Interacting Protein Info
UniProt ID
SHC1_HUMAN 
Synonyms SHC; SHCA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [40]
References  Top
REF 1 Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity. Sci Signal. 2014 Oct 7;7(346):ra95.
REF 2 Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J. 2011 Jul 15;30(16):3259-73.
REF 3 FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol Cell Biol. 2000 Feb;20(3):979-89.
REF 4 Protein partners in the life history of activated fibroblast growth factor receptors. Proteomics. 2007 Dec;7(24):4565-78.
REF 5 Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem. 1999 Sep 3;274(36):25726-34.
REF 6 Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors. Mol Cell. 2000 Oct;6(4):921-9.
REF 7 FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors. J Biol Chem. 2002 May 10;277(19):17088-94.
REF 8 Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. J Biol Chem. 1998 Jul 17;273(29):17987-90.
REF 9 Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism. J Neurosci. 2004 Nov 17;24(46):10384-92.
REF 10 S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner. J Cell Sci. 2011 Jul 15;124(Pt 14):2389-400.
REF 11 A novel nuclear FGF Receptor-1 partnership with retinoid and Nur receptors during developmental gene programming of embryonic stem cells. J Cell Biochem. 2012 Sep;113(9):2920-36.
REF 12 Fibroblast growth factor-derived peptides: functional agonists of the fibroblast growth factor receptor. J Neurochem. 2008 Feb;104(3):667-82.
REF 13 Identification of residues important both for primary receptor binding and specificity in fibroblast growth factor-7. J Biol Chem. 2000 Nov 10;275(45):34881-6.
REF 14 A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2. J Biol Chem. 2000 May 26;275(21):15933-9.
REF 15 Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1. Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7069-74.
REF 16 FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J. 1991 Jun;10(6):1347-54.
REF 17 Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J. 1990 Sep;9(9):2685-92.
REF 18 Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1. J Biol Chem. 2009 Oct 23;284(43):29905-20.
REF 19 Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: a role for protein kinase A. J Cell Biochem. 2003 Oct 1;90(2):408-23.
REF 20 N-glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co-receptor binding. J Biol Chem. 2006 Sep 15;281(37):27178-89.
REF 21 Fibroblast growth factor 2-antagonist activity of a long-pentraxin 3-derived anti-angiogenic pentapeptide. J Cell Mol Med. 2010 Aug;14(8):2109-21.
REF 22 A distinct basic fibroblast growth factor (FGF-2)/FGF receptor interaction distinguishes urokinase-type plasminogen activator induction from mitogenicity in endothelial cells. Mol Biol Cell. 1996 Mar;7(3):369-81.
REF 23 Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem. 2007 Sep 14;282(37):26687-95.
REF 24 Unliganded fibroblast growth factor receptor 1 forms density-independent dimers. J Biol Chem. 2015 Oct 2;290(40):24166-77.
REF 25 The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Cell. 2009 Aug 7;138(3):514-24.
REF 26 Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants. Mol Cell Biol. 1993 Jul;13(7):3907-18.
REF 27 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 28 Grb14 inhibits FGF receptor signaling through the regulation of PLC recruitment and activation. FEBS Lett. 2010 Nov 5;584(21):4383-8.
REF 29 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. J Biol Chem. 2004 Jul 9;279(28):29325-35.
REF 30 Expression and biological activity of mouse fibroblast growth factor-9. J Biol Chem. 1996 Jan 19;271(3):1726-31.
REF 31 Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity. Sci Rep. 2017 Aug 2;7(1):7121.
REF 32 Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule. J Mol Biol. 2008 Mar 21;377(2):524-34.
REF 33 Fibroblast growth factor receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription control. Mol Biol Cell. 2009 May;20(9):2401-12.
REF 34 Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation. J Biol Chem. 2005 Aug 5;280(31):28451-62.
REF 35 The fibroblast growth factor receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of neural cell adhesion molecule. J Biol Chem. 2006 Nov 17;281(46):35208-16.
REF 36 Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Structure. 2003 Jun;11(6):691-701.
REF 37 Cadherin-11 interacts with the FGF receptor and induces neurite outgrowth through associated downstream signalling. Cell Signal. 2008 Jun;20(6):1061-72.
REF 38 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 39 Bikunin down-regulates heterodimerization between CD44 and growth factor receptors and subsequently suppresses agonist-mediated signaling. J Cell Biochem. 2005 Apr 1;94(5):995-1009.
REF 40 Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells. J Biol Chem. 1995 Oct 6;270(40):23337-44.

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