Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T40192 Target Info
Target Name DNA-binding factor KBF1 (p105)
Synonyms Nuclear factor of kappa light polypeptide gene enhancer in Bcells 1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor NFkappaB p50 subunit; Nuclear factor NFkappaB p105 subunit; Nuclear factor NF-kappa-B p105 subunit; EBP1; EBP-1; DNAbinding factor KBF1
Target Type Clinical trial Target
Gene Name NFKB1
UniProt ID
NFKB1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Reconstituted Complex [3]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Co-localization [6]
4 Co-localization [7]
Kinases [+] 2 Kinases +
Interacting Protein Name Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) Interacting Protein Interacting Protein Info
UniProt ID
M3K8_HUMAN 
Synonyms Tumor progression locus 2; TPL-2; Serine/threonine-protein kinase cot; Proto-oncogene c-Cot; Mitogen-activated protein kinase kinase kinase 8; ESTF; COT; Cancer Osaka thyroid oncogene
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [9]
3 Fluorescence Resonance Energy Transfer [10]
4 Protein-Fragment Complementation Assay [10]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Biochemical Activity [12]
3 Co-localization [7]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Glucocorticoid receptor (NR3C1) Successful Target Interacting Protein Info
UniProt ID
GCR_HUMAN 
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Reconstituted Complex [14]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Yeast two hybrid [16]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [17]
2 Affinity Capture-MS [18]
3 Affinity Capture-MS [19]
4 Affinity Capture-Western [20]
5 Affinity Capture-Western [11]
6 Affinity Capture-Western [21]
7 Affinity Capture-Western [22]
8 Affinity Capture-Western [23]
9 Affinity Capture-Western [24]
10 Affinity Capture-Western [25]
11 Affinity Capture-Western [26]
12 Affinity Capture-Western [27]
13 Co-localization [6]
14 Reconstituted Complex [28]
15 Reconstituted Complex [29]
16 Reconstituted Complex [30]
17 Reconstituted Complex [31]
18 Reconstituted Complex [32]
19 Reconstituted Complex [33]
20 Reconstituted Complex [34]
Interacting Target Name Nuclear factor NF-kappa-B (NFKB) Successful Target Interacting Protein Info
UniProt ID
NFKB2_HUMAN 
Synonyms Oncogene Lyt-10; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Nuclear factor NF-kappa-Bp52 subunit; Nuclear factor NF-kappa-B p100 subunit; Lyt10; Lymphocyte translocation chromosome 10 protein; Lymphocyte translocation chromosome 10; H2TF1; DNA-binding factor KBF2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [17]
2 Affinity Capture-MS [18]
3 Affinity Capture-MS [19]
4 Yeast two hybrid [16]
Interacting Protein Name Transcription factor RelB (RELB) Interacting Protein Interacting Protein Info
UniProt ID
RELB_HUMAN 
Synonyms I.REL; IREL; REL.B
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [17]
2 Affinity Capture-MS [19]
3 Yeast two hybrid [16]
Other proteins [+] 8 Other proteins +
Interacting Protein Name NF-kappa-B inhibitor alpha (NFKBIA) Interacting Protein Interacting Protein Info
UniProt ID
IKBA_HUMAN 
Synonyms IKBA; MAD.3; NFKBI
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [18]
2 Affinity Capture-MS [19]
3 Affinity Capture-Western [35]
4 Affinity Capture-Western [21]
5 Affinity Capture-Western [36]
6 Affinity Capture-Western [37]
7 Affinity Capture-Western [38]
8 Reconstituted Complex [39]
9 Reconstituted Complex [40]
10 Reconstituted Complex [41]
11 Yeast two hybrid [16]
Interacting Protein Name TNFAIP3-interacting protein 2 (TNIP2) Interacting Protein Interacting Protein Info
UniProt ID
TNIP2_HUMAN 
Synonyms ABIN2; FLIP1; KLIP
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [18]
3 Affinity Capture-MS [17]
4 Affinity Capture-MS [19]
5 Affinity Capture-Western [8]
6 Fluorescence Resonance Energy Transfer [10]
7 Yeast two hybrid [16]
Interacting Protein Name F-box/WD repeat-containing protein 1A (BTRC) Interacting Protein Interacting Protein Info
UniProt ID
FBW1A_HUMAN 
Synonyms BETA.TRCP; FBW1A; FBXW1; FBXW1A; FWD1; bTrCP; bTrCP1; betaTrCP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Affinity Capture-Western [42]
3 Affinity Capture-Western [43]
4 Reconstituted Complex [42]
Interacting Target Name Poly [ADP-ribose] polymerase 1 (PARP1) Successful Target Interacting Protein Info
UniProt ID
PARP1_HUMAN 
Synonyms Protein poly-ADP-ribosyltransferase PARP1; PPOL; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [44]
2 Co-localization [44]
3 Reconstituted Complex [29]
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [45]
2 Co-localization [45]
3 Co-localization [7]
Interacting Protein Name Menin (MEN1) Interacting Protein Interacting Protein Info
UniProt ID
MEN1_HUMAN 
Synonyms MEAI; SCG2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Affinity Capture-Western [47]
3 Reconstituted Complex [46]
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [17]
2 Affinity Capture-MS [19]
3 Reconstituted Complex [48]
Interacting Protein Name TNFAIP3-interacting protein 1 (TNIP1) Interacting Protein Interacting Protein Info
UniProt ID
TNIP1_HUMAN 
Synonyms ABIN.1; NAF1; VAN; nip40.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [18]
2 Affinity Capture-Western [49]
3 Yeast two hybrid [16]
References  Top
REF 1 Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation. J Immunol. 2003 Dec 15;171(12):6581-8.
REF 2 Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins. J Biol Chem. 2002 Feb 15;277(7):4973-80.
REF 3 Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1. J Biol Chem. 2003 Nov 14;278(46):45145-53.
REF 4 The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell. 2002 Mar;9(3):625-36.
REF 5 Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J Biol Chem. 2007 Nov 9;282(45):33227-36.
REF 6 NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J. 2006 Jan 11;25(1):139-49.
REF 7 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 8 ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. Mol Cell Biol. 2004 Jun;24(12):5235-48.
REF 9 The tyrosine kinase Syk regulates TPL2 activation signals. J Biol Chem. 2006 Jan 20;281(3):1371-80.
REF 10 Regulation of NF-B by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection. PLoS Pathog. 2017 Oct 30;13(10):e1006697.
REF 11 The death domain of NF-kappa B1 p105 is essential for signal-induced p105 proteolysis. J Biol Chem. 2002 Jul 5;277(27):24162-8.
REF 12 Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha. Mol Cell Biol. 2001 Feb;21(4):1024-35.
REF 13 Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med. 2006 Jan 23;203(1):7-13.
REF 14 Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol Cell Biol. 1995 Feb;15(2):943-53.
REF 15 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
REF 16 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 17 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol. 2004 Feb;6(2):97-105.
REF 18 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 19 TNIP2 is a Hub Protein in the NF-B Network with Both Protein and RNA Mediated Interactions. Mol Cell Proteomics. 2016 Nov;15(11):3435-3449.
REF 20 Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B. Nucleic Acids Res. 1993 Nov 11;21(22):5059-66.
REF 21 Annexin A4 interacts with the NF-kappaB p50 subunit and modulates NF-kappaB transcriptional activity in a Ca2+-dependent manner. Cell Mol Life Sci. 2010 Jul;67(13):2271-81.
REF 22 Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression. J Biol Chem. 2006 Aug 4;281(31):21698-709.
REF 23 Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway. J Biol Chem. 2005 Oct 14;280(41):34538-47.
REF 24 Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. Mol Cell Biol. 2010 Aug;30(16):3929-42.
REF 25 The cytokine-induced conformational switch of nuclear factor B p65 is mediated by p65 phosphorylation. Biochem J. 2014 Feb 1;457(3):401-13.
REF 26 Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-Bs in Toll-like receptor 4 signaling. Mol Biol Cell. 2015 Jan 1;26(1):151-60.
REF 27 ETS transcription factor ESE1/ELF3 orchestrates a positive feedback loop that constitutively activates NF-B and drives prostate cancer progression. Cancer Res. 2013 Jul 15;73(14):4533-47.
REF 28 NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO J. 1991 Jul;10(7):1817-25.
REF 29 Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem. 2005 Dec 9;280(49):40450-64.
REF 30 MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. J Immunol. 2007 Nov 15;179(10):7101-9.
REF 31 Regulation of COX-2 expression in human intestinal myofibroblasts: mechanisms of IL-1-mediated induction. Am J Physiol Cell Physiol. 2002 Apr;282(4):C824-34.
REF 32 Transcriptional regulation of cyclooxygenase 2 by bradykinin and interleukin-1beta in human airway smooth muscle cells: involvement of different promoter elements, transcription factors, and histone h4 acetylation. Mol Cell Biol. 2003 Dec;23(24):9233-44.
REF 33 Role of NF-kappaB in the antiproliferative effect of endothelin-1 and tumor necrosis factor-alpha in human hepatic stellate cells. Involvement of cyclooxygenase-2. J Biol Chem. 1998 Sep 4;273(36):23183-90.
REF 34 ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. J Biol Chem. 2003 Jan 10;278(2):875-84.
REF 35 Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo. J Biol Chem. 1996 Mar 29;271(13):7844-50.
REF 36 Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B. Mol Cell Biol. 1995 May;15(5):2689-96.
REF 37 Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB. Oncogene. 1998 Apr 23;16(16):2131-9.
REF 38 Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NF-kappa B activity in lipopolysaccharide-activated human primary monocytes. J Immunol. 2005 Oct 15;175(8):5423-9.
REF 39 Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB. J Biol Chem. 1998 Sep 25;273(39):25427-35.
REF 40 I(kappa)B(gamma) inhibits DNA binding of NF-kappaB p50 homodimers by interacting with residues that contact DNA. Mol Cell Biol. 1996 Nov;16(11):6477-85.
REF 41 Domain organization of I kappa B alpha and sites of interaction with NF-kappa B p65. Mol Cell Biol. 1995 Apr;15(4):2166-72.
REF 42 betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol. 2003 Jan;23(1):402-13.
REF 43 The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-B Signaling via Partial Degradation of the NF-B Subunit p100. J Biol Chem. 2015 Aug 7;290(32):19558-68.
REF 44 Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1. Oncogene. 2006 Dec 14;25(59):7714-22.
REF 45 Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature. 2005 Apr 14;434(7035):921-6.
REF 46 The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene. 2001 Aug 16;20(36):4917-25.
REF 47 Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer Res. 2006 May 1;66(9):4929-35.
REF 48 Hydrodynamic bead modelling of the 2:1 p50-IkappaBgamma complex. Biophys Chem. 2004 Mar 1;108(1-3):259-71.
REF 49 ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor. Biochem Biophys Res Commun. 2009 Nov 13;389(2):205-10.

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