Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T20333 Target Info
Target Name Macrophage colony-stimulating factor 1 receptor (CSF1R)
Synonyms Proto-oncogene c-Fms; M-CSF-R; FMS; CSF-1R; CSF-1-R; CSF-1 receptor; CD115
Target Type Successful Target
Gene Name CSF1R
Biochemical Class Kinase
UniProt ID
CSF1R_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [2]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
3 Yeast two hybrid [4]
References  Top
REF 1 C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus. Oncogene. 2002 Feb 7;21(7):1079-89.
REF 2 c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms. J Biol Chem. 2002 Apr 26;277(17):14635-40.
REF 3 CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins. J Cell Biochem. 1999 Jan 1;72(1):119-34.
REF 4 Identification of a second Grb2 binding site in the v-Fms tyrosine kinase. Oncogene. 1997 Sep 25;15(13):1565-72.

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