Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T15514 Target Info
Target Name Hepatocyte nuclear factor 4-alpha (HNF4A)
Synonyms Transcription factor HNF-4; Transcription factor 14; TCF14; TCF-14; Nuclear receptor subfamily 2 group A member 1; NR2A1; HNF4; HNF-4-alpha
Target Type Literature-reported Target
Gene Name HNF4A
Biochemical Class Nuclear hormone receptor
UniProt ID
HNF4A_HUMAN 
Target Interacting Proteins  Top
Mediator complexes [+] 2 Mediator complexes +
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 1 (MED1) Interacting Protein Interacting Protein Info
UniProt ID
MED1_HUMAN 
Synonyms CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
3 Reconstituted Complex [2]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 14 (MED14) Interacting Protein Interacting Protein Info
UniProt ID
MED14_HUMAN 
Synonyms CRSP150; CRSP2; CSRP; CXorf4; DRIP150; EXLM1; RGR1; TRAP170
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Nuclear hormone receptors [+] 2 Nuclear hormone receptors +
Interacting Target Name Orphan nuclear receptor SHP (NR0B2) Literature-reported Target Interacting Protein Info
UniProt ID
NR0B2_HUMAN 
Synonyms Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [3]
2 Reconstituted Complex [4]
3 Yeast two hybrid [5]
4 Yeast two hybrid [6]
Interacting Target Name Pregnane X receptor (NR1I2) Literature-reported Target Interacting Protein Info
UniProt ID
NR1I2_HUMAN 
Synonyms SXR; Steroid and xenobiotic receptor; PXR; Orphan nuclear receptor PXR; Orphan nuclear receptor PAR1; Nuclear receptor subfamily 1 group I member 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [4]
3 Yeast two hybrid [4]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Reconstituted Complex [9]
Transcription regulators [+] 4 Transcription regulators +
Interacting Protein Name PPAR-gamma coactivator 1-alpha (PPARGC1A) Interacting Protein Interacting Protein Info
UniProt ID
PRGC1_HUMAN 
Synonyms LEM6; PGC.1(alpha); PGC.1v; PGC1; PGC1A; PPARGC1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [11]
4 Reconstituted Complex [12]
5 Reconstituted Complex [13]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [11]
3 Reconstituted Complex [15]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Reconstituted Complex [17]
Interacting Protein Name Activated RNA polymerase II transcriptional coactivator p15 (SUB1) Interacting Protein Interacting Protein Info
UniProt ID
TCP4_HUMAN 
Synonyms P15; PC4; p14
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Reconstituted Complex [19]
Other proteins [+] 2 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Co-localization [21]
Interacting Protein Name Nuclear receptor coactivator 6 (NCOA6) Interacting Protein Interacting Protein Info
UniProt ID
NCOA6_HUMAN 
Synonyms AIB3; ASC2; NRC; PRIP; RAP250; TRBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [11]
2 Yeast two hybrid [6]
References  Top
REF 1 Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205. Mol Endocrinol. 2002 Jul;16(7):1502-10.
REF 2 TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol Cell Biol. 2002 Aug;22(15):5626-37.
REF 3 Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes. J Biol Chem. 2010 Aug 6;285(32):24871-81.
REF 4 Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression. Drug Metab Dispos. 2006 May;34(5):756-64.
REF 5 Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression. J Biol Chem. 2001 Nov 9;276(45):41690-9.
REF 6 Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13.
REF 7 Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G74-84.
REF 8 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 9 Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. Mol Endocrinol. 2002 Feb;16(2):402-10.
REF 10 Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol Endocrinol. 2007 Nov;21(11):2698-712.
REF 11 Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. Mol Pharmacol. 2008 Sep;74(3):913-23.
REF 12 Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepat... J Biol Chem. 2004 Oct 22;279(43):45139-47.
REF 13 Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver. Mol Pharmacol. 2011 Jan;79(1):148-56.
REF 14 Functional association between CBP and HNF4 in trans-activation. Biochem Biophys Res Commun. 1997 Dec 29;241(3):664-9.
REF 15 Acetylation regulates transcription factor activity at multiple levels. Mol Cell. 2000 Apr;5(4):745-51.
REF 16 Transcriptional regulation of human eosinophil RNase2 by the liver-enriched hepatocyte nuclear factor 4. J Cell Biochem. 2009 Feb 1;106(2):317-26.
REF 17 Negative autoregulation of HNF-4alpha gene expression by HNF-4alpha1. Biochem J. 2005 May 15;388(Pt 1):325-32.
REF 18 Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. J Biol Chem. 2002 Feb 15;277(7):5054-60.
REF 19 Critical structural elements and multitarget protein interactions of the transcriptional activator AF-1 of hepatocyte nuclear factor 4. J Biol Chem. 1998 Nov 6;273(45):29950-7.
REF 20 Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis. Oncogene. 2003 Aug 28;22(36):5602-13.
REF 21 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.