Content Navigation
( All
None )
| Target General Information |
Top |
| Target ID |
T76497 |
Target Info
|
| Target Name |
Phosphogluconate dehydrogenase (PGD) |
| Synonyms |
PGDH; 6PGDH; 6-phosphogluconate dehydrogenase, decarboxylating; 6-phosphogluconate dehydrogenase |
| Target Type |
Successful Target |
| Gene Name |
PGD |
| Biochemical Class |
CH-OH donor oxidoreductase |
| UniProt ID |
|
| The microRNAs (miRNAs) Regulating This Target |
Top |
| miRNA Mature ID |
hsa-miR-206 |
miRNA Info
|
| miRNA Mature AC |
|
| Sequence |
uggaauguaaggaagugugugg
|
| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
miR-206 miRNA target PGD in cancer cells and non-neoplastic fibroblast cells. |
[1] |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
Luciferase Reporter Assay; Western Blot |
[1] |
| 2 |
Western Blot |
[2] |
| Representative Target(s) Regulated by This miRNA |
Annexin A2 (ANXA2)
|
Target Info
|
|
|
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
| References |
Top |
| REF 1 |
Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis. J Clin Invest. 2013 Jul;123(7):2921-34.
|
| REF 2 |
Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer. Front Pharmacol. 2017 Jun 30;8:421.
|
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.
