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Target General Information |
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Target ID |
T76497 |
Target Info
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Target Name |
Phosphogluconate dehydrogenase (PGD) |
Synonyms |
PGDH; 6PGDH; 6-phosphogluconate dehydrogenase, decarboxylating; 6-phosphogluconate dehydrogenase |
Target Type |
Successful Target |
Gene Name |
PGD |
Biochemical Class |
CH-OH donor oxidoreductase |
UniProt ID |
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The microRNAs (miRNAs) Regulating This Target |
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miRNA Mature ID |
hsa-miR-206 |
miRNA Info
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miRNA Mature AC |
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Sequence |
uggaauguaaggaagugugugg
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miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-206 miRNA target PGD in cancer cells and non-neoplastic fibroblast cells. |
[1] |
Evidence Score (E-score) |
2 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[1] |
2 |
Western Blot |
[2] |
Representative Target(s) Regulated by This miRNA |
Annexin A2 (ANXA2)
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Target Info
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Apoptosis regulator Bcl-2 (BCL-2)
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Target Info
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References |
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REF 1 |
Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis. J Clin Invest. 2013 Jul;123(7):2921-34.
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REF 2 |
Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer. Front Pharmacol. 2017 Jun 30;8:421.
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