Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T73551 Target Info
Target Name Lysine N-methyltransferase 3A (SETD2)
Synonyms p231HBP; hSET2; SET2; SET domain-containing protein 2; Protein-lysine N-methyltransferase SETD2; KMT3A; KIAA1732; Huntingtin-interacting protein B; Huntingtin-interacting protein 1; Huntingtin yeast partner B; Histone-lysine N-methyltransferase SETD2; HYPB; HSPC069; HIP-1; HIF1
Target Type Literature-reported Target
Gene Name SETD2
Biochemical Class Methyltransferase
UniProt ID
Q9BYW2
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-106b-5p miRNA Info
miRNA Mature AC
MIMAT0000680
Sequence uaaagugcugacagugcagau
miRNA Species Homo sapiens
Regulation Mechanism The protein level of SETD2 was significantly increased upon tranfection of antagomir against miR-106b-5p (4.4- to 7.5-fold in 786-O cells, 3.4-to 5.9-fold in SN12-PM6 cells). Moreover, knockdown of miR-106b-5p with miR-106b-5p antagomir increased the luciferase activity in 786-O and SN12-PM6 cells, whereas mutation of miR-106b-5p recognition site abolished these effects. [1]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [1]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
miRNA Mature ID hsa-miR-186-5p miRNA Info
miRNA Mature AC
MIMAT0000456
Sequence caaagaauucuccuuuugggcu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [2]
Representative Target(s) Regulated by This miRNA Casein kinase II alpha (CSNK2A1) Target Info
CSK21_HUMAN
Fibroblast growth factor-2 (FGF2) Target Info
FGF2_HUMAN
miRNA Mature ID hsa-miR-199b-5p miRNA Info
miRNA Mature AC
MIMAT0000263
Sequence cccaguguuuagacuaucuguuc
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Epithelial discoidin domain receptor 1 (DDR1) Target Info
DDR1_HUMAN
Erbb2 tyrosine kinase receptor (HER2) Target Info
ERBB2_HUMAN
miRNA Mature ID hsa-miR-21-5p miRNA Info
miRNA Mature AC
MIMAT0000076
Sequence uagcuuaucagacugauguuga
miRNA Species Homo sapiens
Regulation Mechanism miR-21 is a transcriptional target of SETD2. [4]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [4]
Representative Target(s) Regulated by This miRNA Apoptosis antigen ligand (CD178) Target Info
TNFL6_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-526b-3p miRNA Info
miRNA Mature AC
MIMAT0002836
Sequence gaaagugcuuccuuuuagaggc
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [5]
Representative Target(s) Regulated by This miRNA Lysine N-methyltransferase 3A (SETD2) Target Info
SETD2_HUMAN
Matrix metalloproteinase-1 (MMP-1) Target Info
MMP1_HUMAN
References  Top
REF 1 miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma. Oncotarget. 2015 Feb 28;6(6):4066-79.
REF 2 MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1 regulation. Oncogenesis. 2016 May 9;5:e224.
REF 3 MiR199b suppresses expression of hypoxia-inducible factor 1 (HIF-1) in prostate cancer cells. Int J Mol Sci. 2013 Apr 17;14(4):8422-36.
REF 4 A feedback regulatory loop between HIF-1 and miR-21 in response to hypoxia in cardiomyocytes. FEBS Lett. 2014 Aug 25;588(17):3137-46.
REF 5 miR-526b-3p functions as a tumor suppressor in colon cancer by regulating HIF-1. Am J Transl Res. 2016 Jun 15;8(6):2783-9.

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