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| Target General Information |
Top |
| Target ID |
T39321 |
Target Info
|
| Target Name |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) |
| Synonyms |
Peptidyl-cysteine S-nitrosylase GAPDH; OK/SW-cl.12; GAPD; D-glyceraldehyde-3-phosphate dehydrogenase; CDABP0047 |
| Target Type |
Clinical trial Target |
| Gene Name |
GAPDH |
| Biochemical Class |
Aldehyde/oxo donor oxidoreductase |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
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| miRNA Mature ID |
hsa-miR-644a |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
aguguggcuuucuuagagc
|
| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
GAPDH is a direct target of miR-644a. |
[2] |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
Luciferase Reporter Assay |
[1] |
| 2 |
Luciferase Reporter Assay; Western Blot |
[2] |
| Representative Target(s) Regulated by This miRNA |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
|
Target Info
|
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| miRNA Mature ID |
hsa-miR-29c-3p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
uagcaccauuugaaaucgguua
|
| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
Introduction of mir-29c down-regulated GAPDH at the level of mRNA and inhibited expression of luciferase encoded by vectors having the 3'UTR of SPARC. |
[3] |
| Evidence Score (E-score) |
1 |
+ |
| 1 |
Luciferase Reporter Assay |
[3] |
| Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
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|
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B7 homolog 3 (CD276)
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Target Info
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| References |
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| REF 1 |
MiR-644a Disrupts Oncogenic Transformation and Warburg Effect by Direct Modulation of Multiple Genes of Tumor-Promoting Pathways. Cancer Res. 2019 Apr 15;79(8):1844-1856.
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| REF 2 |
Housekeeping gene selection advisory: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and -actin are targets of miR-644a. PLoS One. 2012;7(10):e47510.
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| REF 3 |
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5874-8.
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