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| Target General Information |
Top |
| Target ID |
T30635 |
Target Info
|
| Target Name |
C-X-C motif chemokine 10 (CXCL10) |
| Synonyms |
Small-inducible cytokine B10; SCYB10; IP-10; INP10; Gamma-IP10; 10 kDa interferon gamma-induced protein |
| Target Type |
Clinical trial Target |
| Gene Name |
CXCL10 |
| Biochemical Class |
Cytokine: CXC chemokine |
| UniProt ID |
|
| The microRNAs (miRNAs) Regulating This Target |
Top |
| miRNA Mature ID |
hsa-miR-15a-5p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
uagcagcacauaaugguuugug
|
| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
CXCL10 expression was upregulated in patients of MG and was a functional target of miR-15a. |
[1] |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
Luciferase Reporter Assay |
[1] |
| 2 |
qPCR |
[2] |
| Representative Target(s) Regulated by This miRNA |
Amyloid beta A4 protein (APP)
|
Target Info
|
|
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Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
| miRNA Mature ID |
hsa-miR-21-5p |
miRNA Info
|
| miRNA Mature AC |
|
| Sequence |
uagcuuaucagacugauguuga
|
| miRNA Species |
Homo sapiens |
| Evidence Score (E-score) |
1 |
+ |
| 1 |
qRT-PCR |
[3] |
| Representative Target(s) Regulated by This miRNA |
Apoptosis antigen ligand (CD178)
|
Target Info
|
|
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Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
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| References |
Top |
| REF 1 |
MiR-15a contributes abnormal immune response in myasthenia gravis by targeting CXCL10. Clin Immunol. 2016 Mar;164:106-13.
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| REF 2 |
MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. Gastroenterology. 2018 Feb;154(3):637-651.e7.
|
| REF 3 |
Pseudorabies viral replication is inhibited by a novel target of miR-21. Virology. 2014 May;456-457:319-28.
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