Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T16263 Target Info
Target Name T-cell-specific protein RANTES (CCL5)
Synonyms Tcellspecific protein RANTES; TCP228; T cellspecific protein P228; T cell-specific protein P228; Smallinducible cytokine A5; Small-inducible cytokine A5; SISdelta; SIS-delta; SCYA5; RANTES(468); Eosinophil chemotactic cytokine; EoCP; D17S136E; CC motif chemokine 5; C-C motif chemokine 5
Target Type Clinical trial Target
Gene Name CCL5
Biochemical Class Cytokine: CC chemokine
UniProt ID
P13501
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-125a-5p miRNA Info
miRNA Mature AC
MIMAT0000443
Sequence ucccugagacccuuuaaccuguga
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 ELISA [1]
2 qRT-PCR [2]
Representative Target(s) Regulated by This miRNA Apoptosis regulator BAK (BAK) Target Info
BAK_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-98-5p miRNA Info
miRNA Mature AC
MIMAT0000096
Sequence ugagguaguaaguuguauuguu
miRNA Species Homo sapiens
Regulation Mechanism miR-98 in reduction of endothelial inflammation via direct targeting of pro-inflammatory mediators, such as CCL5. [3]
Evidence Score (E-score) 2 +
1 ELISA [1]
2 ELISA; Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Aromatase (CYP19A1) Target Info
CP19A_HUMAN
miRNA Mature ID hsa-miR-146a-5p miRNA Info
miRNA Mature AC
MIMAT0000449
Sequence ugagaacugaauuccauggguu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [4]
Representative Target(s) Regulated by This miRNA Activation B7-1 antigen (CD80) Target Info
CD80_HUMAN
Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
miRNA Mature ID hsa-miR-214-3p miRNA Info
miRNA Mature AC
MIMAT0000271
Sequence acagcaggcacagacaggcagu
miRNA Species Homo sapiens
Regulation Mechanism The most highly upregulated chemokine, CCL5, (C-C motif ligand 5) is found to be a direct target of miR-214. [5]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay [5]
Representative Target(s) Regulated by This miRNA Activating transcription factor 4 (ATF-4) Target Info
ATF4_HUMAN
ADP-ribosylation factor-like protein 2 (ARL2) Target Info
ARL2_HUMAN
miRNA Mature ID hsa-let-7g-3p miRNA Info
miRNA Mature AC
MIMAT0004584
Sequence cuguacaggccacugccuugc
miRNA Species Homo sapiens
Regulation Mechanism Let-7g-3p reduces endothelial inflammation via direct targeting of pro-inflammatory mediators CCL5. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Cardiac myosin (MYBPC3) Target Info
MYPC3_HUMAN
Monocyte chemotactic and activating factor (CCL2) Target Info
CCL2_HUMAN
References  Top
REF 1 MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus. Arthritis Rheum. 2010 Nov;62(11):3425-35.
REF 2 Increasing CCL5/CCR5 on CD4+ T cells in peripheral blood of oral lichen planus. Cytokine. 2013 Apr;62(1):141-5.
REF 3 miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions. J Cereb Blood Flow Metab. 2015 Dec;35(12):1957-65.
REF 4 MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes. J Allergy Clin Immunol. 2014 Oct;134(4):836-847.e11.
REF 5 MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov. 2012 Dec;2(12):1100-8.

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