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| Target General Information |
Top |
| Target ID |
T15377 |
Target Info
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| Target Name |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) |
| Synonyms |
SR Ca(2+)Sarcoplasmic/endoplasmic reticulum calcium ATPase 2-ATPase 2; SR Ca(2+)-ATPase 2; SR Ca(2+)-ATPase; SR Ca(2+) pump; SERCA2; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; Cardiacsarcoplasmic reticulum calcium ATPase; CardiacCa2+ ATPase (SERCA2a); Calciumpump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Calcium pump 2; ATP2B |
| Target Type |
Clinical trial Target |
| Gene Name |
ATP2A2 |
| Biochemical Class |
Cation transporting ATPase |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
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| miRNA Mature ID |
hsa-miR-25-3p |
miRNA Info
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| miRNA Mature AC |
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| Sequence |
cauugcacuugucucggucuga
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| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
miRNA25 suppresses intracellular calcium handling in heart muscle by interacting with messenger RNA encoding the sarcoplasmic reticulum calcium uptake pump SERCA2a (also known as ATP2A2). |
[1] |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
In Situ Hybridization; Luciferase Reporter Assay; Western Blot |
[1] |
| 2 |
qRT-PCR |
[2] |
| Representative Target(s) Regulated by This miRNA |
CDK inhibitor 1C p57Kip2 (CDKN1C)
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Target Info
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Cellular tumor antigen p53 (TP53)
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Target Info
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| References |
Top |
| REF 1 |
Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature. 2014 Apr 24;508(7497):531-5.
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| REF 2 |
Increased expression of ryanodine receptor type-2 during atrial fibrillation by miR-106-25 cluster independent mechanism. Exp Cell Res. 2019 Feb 15;375(2):113-117.
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