Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T11309 Target Info
Target Name Monocyte chemotactic and activating factor (CCL2)
Synonyms Small-inducible cytokine A2; SCYA2; Monocyte secretory protein JE; Monocyte chemotactic protein 1; Monocyte chemoattractant protein-1; Monocyte Chemoattractant Protein 1; MCP1; MCP-1; MCAF; HC11; C-C motif chemokine 2
Target Type Clinical trial Target
Gene Name CCL2
Biochemical Class Cytokine: CC chemokine
UniProt ID
P13500
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-206 miRNA Info
miRNA Mature AC
MIMAT0000462
Sequence uggaauguaaggaagugugugg
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 ELISA; Luciferase Reporter Assay; qRT-PCR; Western Blot [1]
2 PAR-CLIP [2]
Representative Target(s) Regulated by This miRNA Annexin A2 (ANXA2) Target Info
ANXA2_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-495-3p miRNA Info
miRNA Mature AC
MIMAT0002817
Sequence aaacaaacauggugcacuucuu
miRNA Species Homo sapiens
Regulation Mechanism miR-495 mimics significantly inhibited the luciferase activity of CCL2-3'UTR vector and this inhibitory effect was absent in the mutated vector and miR-495 target protector group indicating that miR-495 could bind to the 3'UTR of CCL2 in HEK293FT cells. [3]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Endoplasmic reticulum chaperone BiP (HSPA5) Target Info
BIP_HUMAN
Forkhead box protein C1 (FOXC1) Target Info
FOXC1_HUMAN
miRNA Mature ID hsa-miR-98-5p miRNA Info
miRNA Mature AC
MIMAT0000096
Sequence ugagguaguaaguuguauuguu
miRNA Species Homo sapiens
Regulation Mechanism miR-98 in reduction of endothelial inflammation via direct targeting of pro-inflammatory mediators, such as CCL2. [4]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay; Western Blot [4]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Aromatase (CYP19A1) Target Info
CP19A_HUMAN
miRNA Mature ID hsa-let-7g-3p miRNA Info
miRNA Mature AC
MIMAT0004584
Sequence cuguacaggccacugccuugc
miRNA Species Homo sapiens
Regulation Mechanism Let-7g-3p, in reduction of endothelial inflammation via direct targeting of pro-inflammatory mediators such as CCL2. [4]
Evidence Score (E-score) 1 +
1 ELISA; Luciferase Reporter Assay; Western Blot [4]
Representative Target(s) Regulated by This miRNA Cardiac myosin (MYBPC3) Target Info
MYPC3_HUMAN
Monocyte chemotactic and activating factor (CCL2) Target Info
CCL2_HUMAN
References  Top
REF 1 Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling. PLoS Genet. 2016 Aug 19;12(8):e1006244.
REF 2 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods. 2011 May 15;8(7):559-64.
REF 3 MicroRNA-495 regulates the proliferation and apoptosis of human umbilical vein endothelial cells by targeting chemokine CCL2. Thromb Res. 2015 Jan;135(1):146-54.
REF 4 miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions. J Cereb Blood Flow Metab. 2015 Dec;35(12):1957-65.

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