Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92189 | Target Info | |||
| Target Name | N-glycosylase/DNA lyase (OGG1) | ||||
| Synonyms | OGH1; MUTM; MMH | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | OGG1 | ||||
| Biochemical Class | Type-1 OGG1 family | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 8-aminoguanine | Ligand Info | |||||
| Structure Description | Crystal Structure of hogg1 D268E Mutant with Base-Excised DNA and 8-aminoguanine | PDB:1M3Q | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 EVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARYVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTKVA251 DCICLMALDK261 PQAVPVEVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DLRQ
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 8-Bromoguanine | Ligand Info | |||||
| Structure Description | Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine | PDB:1LWW | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [2] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 EVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARYVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTKVA251 DCICLMALDK261 PQAVPVDVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DLRQ
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| Ligand Name: Pentane-3,4-Diol-5-Phosphate | Ligand Info | |||||
| Structure Description | Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine | PDB:1LWW | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [2] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 EVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARYVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTKVA251 DCICLMALDK261 PQAVPVDVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DLRQ
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PED or .PED2 or .PED3 or :3PED;style chemicals stick;color identity;select .A:147 or .A:148 or .A:149 or .A:150 or .A:151 or .A:152 or .A:153 or .A:155 or .A:249 or .A:268 or .A:269 or .A:270 or .A:319 or .A:323; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 2-deoxy-5-O-phosphono-D-erythro-pentose | Ligand Info | |||||
| Structure Description | Crystal Structure of hogg1 D268E Mutant with Base-Excised DNA and 8-aminoguanine | PDB:1M3Q | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 EVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARYVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTKVA251 DCICLMALDK261 PQAVPVEVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DLRQ
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DRZ or .DRZ2 or .DRZ3 or :3DRZ;style chemicals stick;color identity;select .A:45 or .A:147 or .A:148 or .A:149 or .A:150 or .A:151 or .A:152 or .A:155 or .A:249 or .A:268 or .A:270 or .A:319 or .A:323; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 8-Oxo-2'-deoxy-guanosine-5'-monophosphate | Ligand Info | |||||
| Structure Description | Human 8-oxoguanine glycosylase crosslinked with oxoG lesion containing DNA | PDB:6W0M | ||||
| Method | X-ray diffraction | Resolution | 2.37 Å | Mutation | Yes | [3] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 QVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARCVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTQVA251 DCICLMALDK261 PQAVPVDVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DLRQ
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8OG or .8OG2 or .8OG3 or :38OG;style chemicals stick;color identity;select .A:41 or .A:42 or .A:43 or .A:45 or .A:144 or .A:147 or .A:149 or .A:150 or .A:151 or .A:152 or .A:155 or .A:249 or .A:253 or .A:257 or .A:266 or .A:267 or .A:268 or .A:270 or .A:271 or .A:315 or .A:319 or .A:323; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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SER41
4.815
GLY42
2.700
GLN43
4.688
PHE45
3.899
PHE144
3.691
SER147
3.516
ASN149
4.696
ASN150
3.362
ASN151
3.476
ILE152
2.952
ILE155
4.234
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 2-(2-Ethoxyethoxy)ethane-1-thiol | Ligand Info | |||||
| Structure Description | Human 8-oxoguanine glycosylase interrogating fully intrahelical undamaged DNA | PDB:6W0R | ||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | Yes | [3] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 QVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARCVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTKVA251 DCICLMALDK261 PQAVPVDVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .S5Y or .S5Y2 or .S5Y3 or :3S5Y;style chemicals stick;color identity;select .A:145 or .A:149 or .A:203 or .A:204 or .A:206 or .A:207 or .A:245; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 8-OXOGUANINE | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX | PDB:1HU0 | ||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [2] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 EVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARYVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTKVA251 DCICLMALDK261 PQAVPVDVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DLRQ
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OXG or .OXG2 or .OXG3 or :3OXG;style chemicals stick;color identity;select .A:41 or .A:42 or .A:43 or .A:45 or .A:144 or .A:147 or .A:152 or .A:155 or .A:249 or .A:253 or .A:257 or .A:266 or .A:267 or .A:268 or .A:271 or .A:315 or .A:319; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of end products resulting from lesion processing by a DNA glycosylase/lyase. Chem Biol. 2004 Dec;11(12):1643-9. | ||||
| REF 2 | Product-assisted catalysis in base-excision DNA repair. Nat Struct Biol. 2003 Mar;10(3):204-11. | ||||
| REF 3 | The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase. Nat Commun. 2020 Sep 7;11(1):4437. | ||||
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