Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92189 | Target Info | |||
| Target Name | N-glycosylase/DNA lyase (OGG1) | ||||
| Synonyms | OGH1; MUTM; MMH | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | OGG1 | ||||
| Biochemical Class | Type-1 OGG1 family | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 8-aminoguanine | Ligand Info | |||
| Canonical SMILES | C12=C(N=C(N1)N)N=C(NC2=O)N | ||||
| InChI | 1S/C5H6N6O/c6-4-8-1-2(9-4)10-5(7)11-3(1)12/h(H6,6,7,8,9,10,11,12) | ||||
| InChIKey | WYDKPTZGVLTYPG-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 135421887 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 1LWV Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 EVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARYVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTKVA251 DCICLMALDK261 PQAVPVDVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DLRQ
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| PDB ID: 1M3Q Crystal Structure of hogg1 D268E Mutant with Base-Excised DNA and 8-aminoguanine | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [2] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 EVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARYVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTKVA251 DCICLMALDK261 PQAVPVEVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DLRQ
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Product-assisted catalysis in base-excision DNA repair. Nat Struct Biol. 2003 Mar;10(3):204-11. | ||||
| REF 2 | Structures of end products resulting from lesion processing by a DNA glycosylase/lyase. Chem Biol. 2004 Dec;11(12):1643-9. | ||||
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