Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92189 | Target Info | |||
| Target Name | N-glycosylase/DNA lyase (OGG1) | ||||
| Synonyms | OGH1; MUTM; MMH | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | OGG1 | ||||
| Biochemical Class | Type-1 OGG1 family | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 8-Oxo-2'-deoxy-guanosine-5'-monophosphate | Ligand Info | |||
| Canonical SMILES | C1C(C(OC1N2C3=C(C(=O)NC(=N3)N)NC2=O)COP(=O)(O)O)O | ||||
| InChI | 1S/C10H14N5O8P/c11-9-13-7-6(8(17)14-9)12-10(18)15(7)5-1-3(16)4(23-5)2-22-24(19,20)21/h3-5,16H,1-2H2,(H,12,18)(H2,19,20,21)(H3,11,13,14,17)/t3-,4+,5+/m0/s1 | ||||
| InChIKey | AQIVLFLYHYFRKU-VPENINKCSA-N | ||||
| PubChem Compound ID | 135488904 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6W0M Human 8-oxoguanine glycosylase crosslinked with oxoG lesion containing DNA | ||||||
| Method | X-ray diffraction | Resolution | 2.37 Å | Mutation | Yes | [1] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 QVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARCVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTQVA251 DCICLMALDK261 PQAVPVDVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DLRQ
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SER41
4.815
GLY42
2.700
GLN43
4.688
PHE45
3.899
PHE144
3.691
SER147
3.516
ASN149
4.696
ASN150
3.362
ASN151
3.476
ILE152
2.952
ILE155
4.234
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| PDB ID: 6W13 Human 8-oxoguanine glycosylase interrogating fully intrahelical oxoG lesion DNA | ||||||
| Method | X-ray diffraction | Resolution | 2.38 Å | Mutation | Yes | [1] |
| PDB Sequence |
GSEGHRTLAS
18 TPALWASIPC28 PRSELRLDLV38 LPSGQSFRWR48 EQSPAHWSGV58 LADQVWTLTQ 68 TEEQLHCTVY78 RSQASRPTPD91 ELEAVRKYFQ101 LDVTLAQLYH111 HWGSVDSHFQ 121 QVAQKFQGVR131 LLRQDPIECL141 FSFICSSNNN151 IARITGMVER161 LCQAFGPRLI 171 QLDDVTYHGF181 PSLQALAGPE191 VEAHLRKLGL201 GYRARCVSAS211 ARAILEEQGG 221 LAWLQQLRES231 SYEEAHKALC241 ILPGVGTKVA251 DWICLMALDK261 PQAVPVDVHM 271 WHIAQRDYSW281 HPTTSQAKGP291 SPQTNKELGN301 FFRSLWGPYA311 GWAQAVLFSA 321 DLR
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase. Nat Commun. 2020 Sep 7;11(1):4437. | ||||
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