Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T86573 | Target Info | |||
Target Name | HUMAN inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) | ||||
Synonyms | IMPDH-II; IMPDH 2; IMPD2; IMPD 2; IMP dehydrogenase 2 | ||||
Gene Name | IMPDH2 | ||||
Biochemical Class | CH-OH donor oxidoreductase | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Adenosine triphosphate | Ligand Info | |||||
Structure Description | Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament segment reconstruction. | PDB:6UDO | ||||
Method | Electron microscopy | Resolution | 3.21 Å | Mutation | No | [1] |
PDB Sequence |
YVPDDGLTAQ
21 QLFNCGDGLT31 YNDFLILPGY41 IDFTADQVDL51 TSALTKKITL61 KTPLVSSPMD 71 TVTEAGMAIA81 MALTGGIGFI91 HHNCTPEFQA101 NEVRKVKKYE111 QGFITDPVVL 121 SPKDRVRDVF131 EAKARHGFCG141 IPITDTGRMG151 SRLVGIISSR161 DIDFLKEEEH 171 DCFLEEIMTK181 REDLVVAPAG191 ITLKEANEIL201 QRSKKGKLPI211 VNEDDELVAI 221 IARTDLKKNR231 DYPLASKDAK241 KQLLCGAAIG251 THEDDKYRLD261 LLAQAGVDVV 271 VLDSSQGNSI281 FQINMIKYIK291 DKYPNLQVIG301 GNVVTAAQAK311 NLIDAGVDAL 321 RVGMGSGSIC331 ITQEVLACGR341 PQATAVYKVS351 EYARRFGVPV361 IADGGIQNVG 371 HIAKALALGA381 STVMMGSLLA391 ATTEAPGEYF401 FSDGIRLKKY411 RGMGSLDAMI 437 KVAQGVSGAV447 QDKGSIHKFV457 PYLIAGIQHS467 CQDIGAKSLT477 QVRAMMYSGE 487 LKFEKRTSSA497 QVEGGVHSLH507 SYEKRLF
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Ligand Name: C2-MAD | Ligand Info | |||||
Structure Description | Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide | PDB:1NF7 | ||||
Method | X-ray diffraction | Resolution | 2.65 Å | Mutation | No | [2] |
PDB Sequence |
TSYVPDDGLT
19 AQQLFNCGDG29 LTYNDFLILP39 GYIDFTADQV49 DLTSALTKKI59 TLKTPLVSSP 69 MDTVTEAGMA79 IAMALTGGIG89 FIHHNCTPEF99 QANEVRKVKK109 YEQGFITDPV 119 VLSPKGIISS160 RDIDFLEHDC173 FLEEIMTKRE183 DLVVAPAGIT193 LKEANEILQR 203 SKKGKLPIVN213 EDDELVAIIA223 RTLKKNRDYP234 LASKDAKKQL244 LCGAAIGTHE 254 DDKYRLDLLA264 QAGVDVVVLD274 SSQGNSIFQI284 NMIKYIKDKY294 PNLQVIGGNV 304 VTAAQAKNLI314 DAGVDALRVG324 MGSGSICITQ334 EVLACGRPQA344 TAVYKVSEYA 354 RRFGVPVIAD364 GGIQNVGHIA374 KALALGASTV384 MMGSLLAATT394 EAPGEYFFSD 404 GIRLKKYRGM414 GSLDAMIKVA440 QGVSGAVQDK450 GSIHKFVPYL460 IAGIQHSCQD 470 IGAKSLTQVR480 AMMYSGELKF490 EKRTSSAQVE500 GGVHSLHSYE510 KRLF |
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Ligand Name: 6-Chloropurine Riboside, 5'-Monophosphate | Ligand Info | |||||
Structure Description | TERNARY COMPLEX OF HUMAN TYPE-II INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP AND SELENAZOLE ADENINE DINUCLEOTIDE | PDB:1B3O | ||||
Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [3] |
PDB Sequence |
TSYVPDDGLT
19 AQQLFNCGDG29 LTYNDFLILP39 GYIDFTADQV49 DLTSALTKKI59 TLKTPLVSSP 69 MDTVTEAGMA79 IAMALTGGIG89 FIHHNCTPEF99 QANEVRKVKK109 DYPLASKDAK 241 KQLLCGAAIG251 THEDDKYRLD261 LLAQAGVDVV271 VLDSSQGNSI281 FQINMIKYIK 291 DKYPNLQVIG301 GNVVTAAQAK311 NLIDAGVDAL321 RVGMGSRPQA344 TAVYKVSEYA 354 RRFGVPVIAD364 GGIQNVGHIA374 KALALGASTV384 MMGSLLAATT394 EAPGEYDKGS 452 IHKFVPYLIA462 GIQHSCQDIG472 AKSLTQVRAM482 MYSGELKFEK492 RTSSAQV |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CPR or .CPR2 or .CPR3 or :3CPR;style chemicals stick;color identity;select .A:68 or .A:69 or .A:70 or .A:303 or .A:322 or .A:327 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:389; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Ligand Name: Nicotinamide-Adenine-Dinucleotide | Ligand Info | |||||
Structure Description | Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD | PDB:1NFB | ||||
Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [4] |
PDB Sequence |
TSYVPDDGLT
19 AQQLFNCGDG29 LTYNDFLILP39 GYIDFTADQV49 DLTSALTKKI59 TLKTPLVSSP 69 MDTVTEAGMA79 IAMALTGGIG89 FIHHNCTPEF99 QANEVRKVKK109 YEQGFITDPV 119 VLSPGIPITD146 TGRMGSAPAG191 ITLKEANEIL201 QRSKKGKLPI211 VNEDDEVAII 222 ANRDYPLASK238 DAKKQLLCGA248 AIGTHEDDKY258 RLDLLAQAGV268 DVVVLDSSQG 278 NSIFQINMIK288 YIKDKYPNLQ298 VIGGNVVTAA308 QAKNLIDAGV318 DALRVGMGSG 328 SICITQEVLA338 CGRPQATAVY348 KVSEYARRFG358 VPVIADGGIQ368 NVGHIAKALA 378 LGASTVMMGS388 LLAATTEAPG398 EYFFSDGIRL408 KKYRGMDKGS452 IHKFVPYLIA 462 GIQHSCQDIG472 AKSLTQVRAM482 MYSGELKFEK492 RTSSAQ
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NAD or .NAD2 or .NAD3 or :3NAD;style chemicals stick;color identity;select .A:93 or .A:252 or .A:253 or .A:254 or .A:274 or .A:275 or .A:276 or .A:277 or .A:282 or .A:303 or .A:322 or .A:333 or .A:335 or .A:364 or .A:414; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Ligand Name: Selenazole-4-Carboxyamide-Adenine Dinucleotide | Ligand Info | |||||
Structure Description | TERNARY COMPLEX OF HUMAN TYPE-II INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP AND SELENAZOLE ADENINE DINUCLEOTIDE | PDB:1B3O | ||||
Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [3] |
PDB Sequence |
TSYVPDDGLT
19 AQQLFNCGDG29 LTYNDFLILP39 GYIDFTADQV49 DLTSALTKKI59 TLKTPLVSSP 69 MDTVTEAGMA79 IAMALTGGIG89 FIHHNCTPEF99 QANEVRKVKK109 DYPLASKDAK 241 KQLLCGAAIG251 THEDDKYRLD261 LLAQAGVDVV271 VLDSSQGNSI281 FQINMIKYIK 291 DKYPNLQVIG301 GNVVTAAQAK311 NLIDAGVDAL321 RVGMGSRPQA344 TAVYKVSEYA 354 RRFGVPVIAD364 GGIQNVGHIA374 KALALGASTV384 MMGSLLAATT394 EAPGEYDKGS 452 IHKFVPYLIA462 GIQHSCQDIG472 AKSLTQVRAM482 MYSGELKFEK492 RTSSAQV |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SAE or .SAE2 or .SAE3 or :3SAE;style chemicals stick;color identity;select .A:93 or .A:252 or .A:253 or .A:254 or .A:274 or .A:275 or .A:276 or .A:277 or .A:282 or .A:303 or .A:322 or .A:324 or .A:325 or .A:364; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: Guanosine-5'-Diphosphate | Ligand Info | |||||
Structure Description | Structure of human IMP dehydrogenase, isoform 2, bound to GDP | PDB:6I0M | ||||
Method | X-ray diffraction | Resolution | 2.57 Å | Mutation | No | [5] |
PDB Sequence |
YVPDDGLTAQ
21 QLFNCGDGLT31 YNDFLILPGY41 IDFTADQVDL51 TSALTKKITL61 KTPLVSSPMD 71 TVTEAGMAIA81 MALTGGIGFI91 HHNCTPEFQA101 NEVRKVKKYE111 QGFITDPVVL 121 SPKDRVRDVF131 EAKARHGFCG141 IPITDTGRMG151 SRLVGIISSR161 DIDFLEHDCF 174 LEEIMTKRED184 LVVAPAGITL194 KEANEILQRS204 KKGKLPIVNE214 DDELVAIIAR 224 TDLKKNRDYP234 LASKDAKKQL244 LCGAAIGTHE254 DDKYRLDLLA264 QAGVDVVVLD 274 SSQGNSIFQI284 NMIKYIKDKY294 PNLQVIGGNV304 VTAAQAKNLI314 DAGVDALRVG 324 MGSGSITQEV336 LACGRPQATA346 VYKVSEYARR356 FGVPVIADGG366 IQNVGHIAKA 376 LALGASTVMM386 GSLLAATTEA396 PGEYFFSDGM414 GSLDAQDKGS452 IHKFVPYLIA 462 GIQHSCQDIG472 AKSLTQVRAM482 MYSGELKFEK492 RTSSAQVEGG502 |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GDP or .GDP2 or .GDP3 or :3GDP;style chemicals stick;color identity;select .A:109 or .A:110 or .A:111 or .A:112 or .A:113 or .A:115 or .A:117 or .A:118 or .A:119 or .A:138 or .A:139 or .A:140 or .A:141 or .A:142 or .A:143 or .A:157 or .A:158 or .A:159 or .A:160 or .A:161 or .A:162 or .A:179 or .A:180 or .A:184 or .A:185 or .A:186 or .A:194 or .A:195 or .A:198 or .A:204 or .A:206 or .A:207 or .A:208 or .A:209 or .A:210 or .A:221 or .A:222 or .A:223 or .A:225 or .A:226 or .A:227 or .A:229 or .A:230 or .A:238 or .A:242; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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LYS109
2.112
TYR110
2.619
GLU111
2.459
GLN112
1.927
GLY113
2.809
ILE115
2.600
ASP117
4.481
PRO118
2.574
VAL119
2.550
GLY138
4.946
PHE139
2.297
CYS140
1.813
GLY141
2.251
ILE142
4.382
PRO143
4.884
ILE157
2.974
ILE158
3.535
SER159
1.810
SER160
2.652
ARG161
2.337
ASP162
1.949
MET179
4.483
THR180
1.885
ASP184
2.168
LEU185
1.578
VAL186
1.357
LEU194
2.712
LYS195
2.784
ASN198
1.993
SER204
4.992
LYS206
2.390
GLY207
1.911
LYS208
1.540
LEU209
4.051
PRO210
3.519
ILE221
3.734
ILE222
3.333
ALA223
2.434
THR225
2.336
ASP226
1.604
LEU227
2.955
LYS229
2.418
ASN230
2.991
LYS238
2.698
LYS242
2.277
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Ligand Name: Guanosine-5'-Monophosphate | Ligand Info | |||||
Structure Description | Structure of human IMP dehydrogenase, isoform 2, bound to GDP | PDB:6I0M | ||||
Method | X-ray diffraction | Resolution | 2.57 Å | Mutation | No | [5] |
PDB Sequence |
YVPDDGLTAQ
21 QLFNCGDGLT31 YNDFLILPGY41 IDFTADQVDL51 TSALTKKITL61 KTPLVSSPMD 71 TVTEAGMAIA81 MALTGGIGFI91 HHNCTPEFQA101 NEVRKVKKYE111 QGFITDPVVL 121 SPKDRVRDVF131 EAKARHGFCG141 IPITDTGRMG151 SRLVGIISSR161 DIDFLEHDCF 174 LEEIMTKRED184 LVVAPAGITL194 KEANEILQRS204 KKGKLPIVNE214 DDELVAIIAR 224 TDLKKNRDYP234 LASKDAKKQL244 LCGAAIGTHE254 DDKYRLDLLA264 QAGVDVVVLD 274 SSQGNSIFQI284 NMIKYIKDKY294 PNLQVIGGNV304 VTAAQAKNLI314 DAGVDALRVG 324 MGSGSITQEV336 LACGRPQATA346 VYKVSEYARR356 FGVPVIADGG366 IQNVGHIAKA 376 LALGASTVMM386 GSLLAATTEA396 PGEYFFSDGM414 GSLDAQDKGS452 IHKFVPYLIA 462 GIQHSCQDIG472 AKSLTQVRAM482 MYSGELKFEK492 RTSSAQVEGG502 |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5GP or .5GP2 or .5GP3 or :35GP;style chemicals stick;color identity;select .A:68 or .A:69 or .A:70 or .A:274 or .A:276 or .A:303 or .A:322 or .A:325 or .A:326 or .A:327 or .A:328 or .A:329 or .A:332 or .A:333 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:389 or .A:414 or .A:415 or .A:416; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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SER68
1.649
PRO69
3.617
MET70
2.488
ASP274
4.601
SER276
3.967
ASN303
3.984
ARG322
1.270
MET325
4.630
GLY326
3.536
SER327
3.868
GLY328
2.561
SER329
3.830
ILE332
4.669
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Ligand Name: Guanosine-5'-Triphosphate | Ligand Info | |||||
Structure Description | Structure of human IMP dehydrogenase, isoform 2, bound to GTP | PDB:6I0O | ||||
Method | X-ray diffraction | Resolution | 2.62 Å | Mutation | No | [5] |
PDB Sequence |
SYVPDDGLTA
20 QQLFNCGDGL30 TYNDFLILPG40 YIDFTADQVD50 LTSALTKKIT60 LKTPLVSSPM 70 DTVTEAGMAI80 AMALTGGIGF90 IHHNCTPEFQ100 ANEVRKVKKY110 EQGFITDPVV 120 LSPKDRVRDV130 FEAKARHGFC140 GIPITDTGRM150 GSRLVGIISS160 RDIDFLKEEE 170 HDCFLEEIMT180 KREDLVVAPA190 GITLKEANEI200 LQRSKKGKLP210 IVNEDDELVA 220 IIARTDLKKN230 RDYPLASKDA240 KKQLLCGAAI250 GTHEDDKYRL260 DLLAQAGVDV 270 VVLDSSQGNS280 IFQINMIKYI290 KDKYPNLQVI300 GGNVVTAAQA310 KNLIDAGVDA 320 LRVGMEVLAC339 GRPQATAVYK349 VSEYARRFGV359 PVIADGGIQN369 VGHIAKALAL 379 GASTVMMGSL389 LAATTEAPGE399 YFFSKGSIHK455 FVPYLIAGIQ465 HSCQDIGAKS 475 LTQVRAMMYS485 GELKFEKRTS495 SAQV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GTP or .GTP2 or .GTP3 or :3GTP;style chemicals stick;color identity;select .A:62 or .A:109 or .A:110 or .A:111 or .A:112 or .A:113 or .A:114 or .A:115 or .A:117 or .A:118 or .A:119 or .A:134 or .A:138 or .A:139 or .A:140 or .A:141 or .A:142 or .A:143 or .A:157 or .A:158 or .A:159 or .A:160 or .A:161 or .A:162 or .A:179 or .A:180 or .A:184 or .A:185 or .A:186 or .A:194 or .A:195 or .A:198 or .A:202 or .A:205 or .A:206 or .A:207 or .A:208 or .A:209 or .A:210 or .A:221 or .A:222 or .A:223 or .A:225 or .A:226 or .A:227 or .A:229 or .A:230 or .A:233 or .A:234 or .A:235 or .A:236 or .A:238 or .A:242; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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LYS62
3.301
LYS109
2.515
TYR110
2.871
GLU111
2.492
GLN112
2.152
GLY113
2.417
PHE114
4.834
ILE115
2.695
ASP117
4.479
PRO118
2.494
VAL119
2.638
LYS134
3.398
GLY138
3.914
PHE139
2.549
CYS140
2.125
GLY141
1.583
ILE142
3.585
PRO143
4.107
ILE157
2.242
ILE158
3.235
SER159
1.842
SER160
1.606
ARG161
2.424
ASP162
2.319
MET179
4.979
THR180
2.461
ASP184
2.620
LEU185
2.488
VAL186
1.843
LEU194
2.622
LYS195
3.764
ASN198
1.962
GLN202
4.486
LYS205
4.572
LYS206
2.699
GLY207
1.740
LYS208
2.007
LEU209
3.904
PRO210
3.456
ILE221
3.620
ILE222
3.374
ALA223
3.603
THR225
2.173
ASP226
1.908
LEU227
3.072
LYS229
1.710
ASN230
1.675
TYR233
3.054
PRO234
2.756
LEU235
4.212
ALA236
3.653
LYS238
1.785
LYS242
2.196
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Ligand Name: Inosinic Acid | Ligand Info | |||||
Structure Description | Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Filament assembly interface reconstruction. | PDB:6UDP | ||||
Method | Electron microscopy | Resolution | 2.95 Å | Mutation | No | [1] |
PDB Sequence |
MADYLISGGT
10 SYVPDDGLTA20 QQLFNCGDGL30 TYNDFLILPG40 YIDFTADQVD50 LTSALTKKIT 60 LKTPLVSSPM70 DTVTEAGMAI80 AMALTGGIGF90 IHHNCTPEFQ100 ANEVRKVKKY 110 YPLASKDAKK242 QLLCGAAIGT252 HEDDKYRLDL262 LAQAGVDVVV272 LDSSQGNSIF 282 QINMIKYIKD292 KYPNLQVIGG302 NVVTAAQAKN312 LIDAGVDALR322 VGMGSGSICI 332 TQEVLACGRP342 QATAVYKVSE352 YARRFGVPVI362 ADGGIQNVGH372 IAKALALGAS 382 TVMMGSLLAA392 TTEAPGEYFF402 SDGIRLKKYR412 GMGSLDAMIK438 VAQGVSGAVQ 448 DKGSIHKFVP458 YLIAGIQHSC468 QDIGAKSLTQ478 VRAMMYSGEL488 KFEKRTSSAQ 498 VEGGVHSLHS508 YEKRLF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IMP or .IMP2 or .IMP3 or :3IMP;style chemicals stick;color identity;select .A:68 or .A:70 or .A:303 or .A:322 or .A:327 or .A:328 or .A:329 or .A:330 or .A:331 or .A:333 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:389 or .A:411 or .A:413 or .A:414 or .A:415 or .A:416 or .A:441 or .A:442; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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SER68
3.077
MET70
3.645
ASN303
3.795
ARG322
3.145
SER327
4.502
GLY328
3.836
SER329
2.511
ILE330
3.375
CYS331
3.497
THR333
3.799
ASP364
2.479
GLY365
3.257
GLY366
3.269
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Ligand Name: Ribavirin monophosphate | Ligand Info | |||||
Structure Description | Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide | PDB:1NF7 | ||||
Method | X-ray diffraction | Resolution | 2.65 Å | Mutation | No | [2] |
PDB Sequence |
TSYVPDDGLT
19 AQQLFNCGDG29 LTYNDFLILP39 GYIDFTADQV49 DLTSALTKKI59 TLKTPLVSSP 69 MDTVTEAGMA79 IAMALTGGIG89 FIHHNCTPEF99 QANEVRKVKK109 YEQGFITDPV 119 VLSPKGIISS160 RDIDFLEHDC173 FLEEIMTKRE183 DLVVAPAGIT193 LKEANEILQR 203 SKKGKLPIVN213 EDDELVAIIA223 RTLKKNRDYP234 LASKDAKKQL244 LCGAAIGTHE 254 DDKYRLDLLA264 QAGVDVVVLD274 SSQGNSIFQI284 NMIKYIKDKY294 PNLQVIGGNV 304 VTAAQAKNLI314 DAGVDALRVG324 MGSGSICITQ334 EVLACGRPQA344 TAVYKVSEYA 354 RRFGVPVIAD364 GGIQNVGHIA374 KALALGASTV384 MMGSLLAATT394 EAPGEYFFSD 404 GIRLKKYRGM414 GSLDAMIKVA440 QGVSGAVQDK450 GSIHKFVPYL460 IAGIQHSCQD 470 IGAKSLTQVR480 AMMYSGELKF490 EKRTSSAQVE500 GGVHSLHSYE510 KRLF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .RVP or .RVP2 or .RVP3 or :3RVP;style chemicals stick;color identity;select .A:68 or .A:69 or .A:70 or .A:303 or .A:322 or .A:327 or .A:328 or .A:329 or .A:330 or .A:331 or .A:332 or .A:333 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:411 or .A:413 or .A:414 or .A:415 or .A:416 or .A:441 or .A:442 or .A:443; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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SER68
2.626
PRO69
4.541
MET70
3.441
ASN303
3.620
ARG322
3.647
SER327
3.709
GLY328
3.007
SER329
2.973
ILE330
3.329
CYS331
3.279
ILE332
4.270
THR333
4.287
ASP364
2.430
GLY365
3.493
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References | Top | ||||
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REF 1 | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife. 2020 Jan 30;9:e53243. | ||||
REF 2 | Crystal Structure of Human Inosine Monophosphate Dehydrogenase type II complexed with the MPA/NAD analog C2-MAD | ||||
REF 3 | Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3531-6. | ||||
REF 4 | The Conformation of NAD Bound to Human Inosine Monophosphate Dehydrogenase Type II | ||||
REF 5 | A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J Mol Biol. 2019 Mar 1;431(5):956-969. |
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