Target Binding Site Detail
Target General Information | Top | ||||
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Target ID | T86573 | Target Info | |||
Target Name | HUMAN inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) | ||||
Synonyms | IMPDH-II; IMPDH 2; IMPD2; IMPD 2; IMP dehydrogenase 2 | ||||
Gene Name | IMPDH2 | ||||
Biochemical Class | CH-OH donor oxidoreductase | ||||
UniProt ID |
Ligand General Information | Top | ||||
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Ligand Name | 6-Chloropurine Riboside, 5'-Monophosphate | Ligand Info | |||
Canonical SMILES | C1=[N+](C2=C(N1)C(=NC=N2)Cl)C3C(C(C(O3)COP(=O)(O)O)O)O | ||||
InChI | 1S/C10H12ClN4O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,18,19,20)/p+1/t4-,6-,7-,10-/m1/s1 | ||||
InChIKey | ALOBOMYIOYNCBS-KQYNXXCUSA-O | ||||
PubChem Compound ID | 17753915 |
Drug Binding Sites of Target | Top | |||||
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PDB ID: 1B3O TERNARY COMPLEX OF HUMAN TYPE-II INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP AND SELENAZOLE ADENINE DINUCLEOTIDE | ||||||
Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [1] |
PDB Sequence |
TSYVPDDGLT
19 AQQLFNCGDG29 LTYNDFLILP39 GYIDFTADQV49 DLTSALTKKI59 TLKTPLVSSP 69 MDTVTEAGMA79 IAMALTGGIG89 FIHHNCTPEF99 QANEVRKVKK109 DYPLASKDAK 241 KQLLCGAAIG251 THEDDKYRLD261 LLAQAGVDVV271 VLDSSQGNSI281 FQINMIKYIK 291 DKYPNLQVIG301 GNVVTAAQAK311 NLIDAGVDAL321 RVGMGSRPQA344 TAVYKVSEYA 354 RRFGVPVIAD364 GGIQNVGHIA374 KALALGASTV384 MMGSLLAATT394 EAPGEYDKGS 452 IHKFVPYLIA462 GIQHSCQDIG472 AKSLTQVRAM482 MYSGELKFEK492 RTSSAQV |
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PDB ID: 1NFB Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD | ||||||
Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [2] |
PDB Sequence |
TSYVPDDGLT
19 AQQLFNCGDG29 LTYNDFLILP39 GYIDFTADQV49 DLTSALTKKI59 TLKTPLVSSP 69 MDTVTEAGMA79 IAMALTGGIG89 FIHHNCTPEF99 QANEVRKVKK109 YEQGFITDPV 119 VLSPGIPITD146 TGRMGSAPAG191 ITLKEANEIL201 QRSKKGKLPI211 VNEDDEVAII 222 ANRDYPLASK238 DAKKQLLCGA248 AIGTHEDDKY258 RLDLLAQAGV268 DVVVLDSSQG 278 NSIFQINMIK288 YIKDKYPNLQ298 VIGGNVVTAA308 QAKNLIDAGV318 DALRVGMGSG 328 SICITQEVLA338 CGRPQATAVY348 KVSEYARRFG358 VPVIADGGIQ368 NVGHIAKALA 378 LGASTVMMGS388 LLAATTEAPG398 EYFFSDGIRL408 KKYRGMDKGS452 IHKFVPYLIA 462 GIQHSCQDIG472 AKSLTQVRAM482 MYSGELKFEK492 RTSSAQ
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SER68
2.788
PRO69
4.824
MET70
3.398
ASN303
4.169
ARG322
3.746
SER327
3.768
GLY328
2.995
SER329
2.879
ILE330
3.678
CYS331
1.854
ILE332
4.578
|
References | Top | ||||
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REF 1 | Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3531-6. | ||||
REF 2 | The Conformation of NAD Bound to Human Inosine Monophosphate Dehydrogenase Type II |
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