Target Binding Site Detail
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T86573 | Target Info | |||
Target Name | HUMAN inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) | ||||
Synonyms | IMPDH-II; IMPDH 2; IMPD2; IMPD 2; IMP dehydrogenase 2 | ||||
Gene Name | IMPDH2 | ||||
Biochemical Class | CH-OH donor oxidoreductase | ||||
UniProt ID |
Ligand General Information | Top | ||||
---|---|---|---|---|---|
Ligand Name | Inosinic Acid | Ligand Info | |||
Canonical SMILES | C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O | ||||
InChI | 1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 | ||||
InChIKey | GRSZFWQUAKGDAV-KQYNXXCUSA-N | ||||
PubChem Compound ID | 135398640 |
Drug Binding Sites of Target | Top | |||||
---|---|---|---|---|---|---|
PDB ID: 6U8S Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Filament assembly interface reconstruction. | ||||||
Method | Electron microscopy | Resolution | 3.14 Å | Mutation | No | [1] |
PDB Sequence |
MADYLISGGT
10 SYVPDDGLTA20 QQLFNCGDGL30 TYNDFLILPG40 YIDFTADQVD50 LTSALTKKIT 60 LKTPLVSSPM70 DTVTEAGMAI80 AMALTGGIGF90 IHHNCTPEFQ100 ANEVRKVKKY 110 YPLASKDAKK242 QLLCGAAIGT252 HEDDKYRLDL262 LAQAGVDVVV272 LDSSQGNSIF 282 QINMIKYIKD292 KYPNLQVIGG302 NVVTAAQAKN312 LIDAGVDALR322 VGMGSGSICI 332 TQEVLACGRP342 QATAVYKVSE352 YARRFGVPVI362 ADGGIQNVGH372 IAKALALGAS 382 TVMMGSLLAA392 TTEAPGEYFF402 SDGIRLKKYR412 GMGSLDAMIK438 VAQGVSGAVQ 448 DKGSIHKFVP458 YLIAGIQHSC468 QDIGAKSLTQ478 VRAMMYSGEL488 KFEKRTSSAQ 498 VEGGVHSLHS508 YEKRLF
|
|||||
|
SER68
3.076
MET70
3.457
ASN303
4.246
ARG322
3.022
GLY324
4.232
SER327
4.540
GLY328
3.320
SER329
2.505
ILE330
4.328
CYS331
1.628
ILE332
4.899
THR333
4.795
ASP364
3.308
GLY365
3.399
|
|||||
PDB ID: 6UDP Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Filament assembly interface reconstruction. | ||||||
Method | Electron microscopy | Resolution | 2.95 Å | Mutation | No | [1] |
PDB Sequence |
MADYLISGGT
10 SYVPDDGLTA20 QQLFNCGDGL30 TYNDFLILPG40 YIDFTADQVD50 LTSALTKKIT 60 LKTPLVSSPM70 DTVTEAGMAI80 AMALTGGIGF90 IHHNCTPEFQ100 ANEVRKVKKY 110 YPLASKDAKK242 QLLCGAAIGT252 HEDDKYRLDL262 LAQAGVDVVV272 LDSSQGNSIF 282 QINMIKYIKD292 KYPNLQVIGG302 NVVTAAQAKN312 LIDAGVDALR322 VGMGSGSICI 332 TQEVLACGRP342 QATAVYKVSE352 YARRFGVPVI362 ADGGIQNVGH372 IAKALALGAS 382 TVMMGSLLAA392 TTEAPGEYFF402 SDGIRLKKYR412 GMGSLDAMIK438 VAQGVSGAVQ 448 DKGSIHKFVP458 YLIAGIQHSC468 QDIGAKSLTQ478 VRAMMYSGEL488 KFEKRTSSAQ 498 VEGGVHSLHS508 YEKRLF
|
|||||
|
SER68
3.077
MET70
3.645
ASN303
3.795
ARG322
3.145
SER327
4.502
GLY328
3.836
SER329
2.511
ILE330
3.375
CYS331
3.497
THR333
3.799
ASP364
2.479
GLY365
3.257
GLY366
3.269
|
|||||
PDB ID: 6U8E Human IMPDH2 treated with ATP, IMP, and NAD+. Filament assembly interface reconstruction. | ||||||
Method | Electron microscopy | Resolution | 3.03 Å | Mutation | No | [1] |
PDB Sequence |
MADYLISGGT
10 SYVPDDGLTA20 QQLFNCGDGL30 TYNDFLILPG40 YIDFTADQVD50 LTSALTKKIT 60 LKTPLVSSPM70 DTVTEAGMAI80 AMALTGGIGF90 IHHNCTPEFQ100 ANEVRKVKKY 110 PLASKDAKKQ243 LLCGAAIGTH253 EDDKYRLDLL263 AQAGVDVVVL273 DSSQGNSIFQ 283 INMIKYIKDK293 YPNLQVIGGN303 VVTAAQAKNL313 IDAGVDALRV323 GMGSGSICIT 333 QEVLACGRPQ343 ATAVYKVSEY353 ARRFGVPVIA363 DGGIQNVGHI373 AKALALGAST 383 VMMGSLLAAT393 TEAPGEYFFS403 DGIRLKKYRG413 MGSLDAMIKV439 AQGVSGAVQD 449 KGSIHKFVPY459 LIAGIQHSCQ469 DIGAKSLTQV479 RAMMYSGELK489 FEKRTSSAQV 499 EGGVHSLHSY509 EKRLF
|
|||||
|
SER68
3.478
PRO69
4.928
MET70
3.750
ASN303
3.966
ARG322
3.014
GLY324
4.764
SER327
4.158
GLY328
3.302
SER329
2.524
ILE330
3.453
CYS331
1.360
ILE332
4.396
THR333
4.350
ASP364
2.352
GLY365
3.323
|
|||||
PDB ID: 6UDO Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament segment reconstruction. | ||||||
Method | Electron microscopy | Resolution | 3.21 Å | Mutation | No | [1] |
PDB Sequence |
YVPDDGLTAQ
21 QLFNCGDGLT31 YNDFLILPGY41 IDFTADQVDL51 TSALTKKITL61 KTPLVSSPMD 71 TVTEAGMAIA81 MALTGGIGFI91 HHNCTPEFQA101 NEVRKVKKYE111 QGFITDPVVL 121 SPKDRVRDVF131 EAKARHGFCG141 IPITDTGRMG151 SRLVGIISSR161 DIDFLKEEEH 171 DCFLEEIMTK181 REDLVVAPAG191 ITLKEANEIL201 QRSKKGKLPI211 VNEDDELVAI 221 IARTDLKKNR231 DYPLASKDAK241 KQLLCGAAIG251 THEDDKYRLD261 LLAQAGVDVV 271 VLDSSQGNSI281 FQINMIKYIK291 DKYPNLQVIG301 GNVVTAAQAK311 NLIDAGVDAL 321 RVGMGSGSIC331 ITQEVLACGR341 PQATAVYKVS351 EYARRFGVPV361 IADGGIQNVG 371 HIAKALALGA381 STVMMGSLLA391 ATTEAPGEYF401 FSDGIRLKKY411 RGMGSLDAMI 437 KVAQGVSGAV447 QDKGSIHKFV457 PYLIAGIQHS467 CQDIGAKSLT477 QVRAMMYSGE 487 LKFEKRTSSA497 QVEGGVHSLH507 SYEKRLF
|
|||||
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IMP or .IMP2 or .IMP3 or :3IMP;style chemicals stick;color identity;select .A:68 or .A:70 or .A:303 or .A:322 or .A:324 or .A:327 or .A:328 or .A:329 or .A:330 or .A:331 or .A:333 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:389 or .A:411 or .A:413 or .A:414 or .A:415 or .A:416 or .A:441 or .A:442; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER68
3.057
MET70
3.475
ASN303
3.913
ARG322
3.112
GLY324
4.193
SER327
4.366
GLY328
3.317
SER329
2.525
ILE330
3.405
CYS331
1.627
THR333
3.525
ASP364
2.500
GLY365
3.442
GLY366
3.312
|
|||||
PDB ID: 6U9O Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Fully compressed filament segment reconstruction. | ||||||
Method | Electron microscopy | Resolution | 3.36 Å | Mutation | No | [1] |
PDB Sequence |
SYVPDDGLTA
20 QQLFNCGDGL30 TYNDFLILPG40 YIDFTADQVD50 LTSALTKKIT60 LKTPLVSSPM 70 DTVTEAGMAI80 AMALTGGIGF90 IHHNCTPEFQ100 ANEVRKVKKY110 EQGFITDPVV 120 LSPKDRVRDV130 FEAKARHGFC140 GIPITDTGRM150 GSRLVGIISS160 RDIDFLKEEE 170 HDCFLEEIMT180 KREDLVVAPA190 GITLKEANEI200 LQRSKKGKLP210 IVNEDDELVA 220 IIARTDLKKN230 RDYPLASKDA240 KKQLLCGAAI250 GTHEDDKYRL260 DLLAQAGVDV 270 VVLDSSQGNS280 IFQINMIKYI290 KDKYPNLQVI300 GGNVVTAAQA310 KNLIDAGVDA 320 LRVGMGSGSI330 CITQEVLACG340 RPQATAVYKV350 SEYARRFGVP360 VIADGGIQNV 370 GHIAKALALG380 ASTVMMGSLL390 AATTEAPGEY400 FFSDGIRLKK410 YRGMGSLDAM 420 IKVAQGVSGA446 VQDKGSIHKF456 VPYLIAGIQH466 SCQDIGAKSL476 TQVRAMMYSG 486 ELKFEKRTSS496 AQVEGGVHSL506 HSYEKRLF
|
|||||
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IMP or .IMP2 or .IMP3 or :3IMP;style chemicals stick;color identity;select .A:68 or .A:69 or .A:70 or .A:303 or .A:322 or .A:327 or .A:328 or .A:329 or .A:330 or .A:331 or .A:332 or .A:333 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:389 or .A:411 or .A:413 or .A:414 or .A:415 or .A:416 or .A:441 or .A:442; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER68
2.764
PRO69
4.661
MET70
3.457
ASN303
4.638
ARG322
3.210
SER327
4.357
GLY328
3.263
SER329
2.514
ILE330
3.486
CYS331
1.628
ILE332
4.834
THR333
4.789
ASP364
2.604
GLY365
3.328
|
|||||
PDB ID: 6UA4 Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (3/4 compressed, 1/4 extended) segment reconstruction. | ||||||
Method | Electron microscopy | Resolution | 3.65 Å | Mutation | No | [1] |
PDB Sequence |
SYVPDDGLTA
20 QQLFNCGDGL30 TYNDFLILPG40 YIDFTADQVD50 LTSALTKKIT60 LKTPLVSSPM 70 DTVTEAGMAI80 AMALTGGIGF90 IHHNCTPEFQ100 ANEVRKVKKY110 EQGFITDPVV 120 LSPKDRVRDV130 FEAKARHGFC140 GIPITDTGRM150 GSRLVGIISS160 RDIDFLKEEE 170 HDCFLEEIMT180 KREDLVVAPA190 GITLKEANEI200 LQRSKKGKLP210 IVNEDDELVA 220 IIARTDLKKN230 RDYPLASKDA240 KKQLLCGAAI250 GTHEDDKYRL260 DLLAQAGVDV 270 VVLDSSQGNS280 IFQINMIKYI290 KDKYPNLQVI300 GGNVVTAAQA310 KNLIDAGVDA 320 LRVGMGSGSI330 CITQEVLACG340 RPQATAVYKV350 SEYARRFGVP360 VIADGGIQNV 370 GHIAKALALG380 ASTVMMGSLL390 AATTEAPGEY400 FFSDGIRLKK410 YRGMGSLDAM 420 IKVAQGVSGA446 VQDKGSIHKF456 VPYLIAGIQH466 SCQDIGAKSL476 TQVRAMMYSG 486 ELKFEKRTSS496 AQVEGGVHSL506 HSYEKRLF
|
|||||
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IMP or .IMP2 or .IMP3 or :3IMP;style chemicals stick;color identity;select .A:68 or .A:70 or .A:303 or .A:322 or .A:324 or .A:327 or .A:328 or .A:329 or .A:330 or .A:331 or .A:332 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:389 or .A:411 or .A:413 or .A:414 or .A:415 or .A:416 or .A:441 or .A:442; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER68
2.881
MET70
3.440
ASN303
4.310
ARG322
2.940
GLY324
4.439
SER327
4.242
GLY328
3.528
SER329
2.719
ILE330
3.521
CYS331
3.495
ILE332
4.837
ASP364
2.362
GLY365
3.308
GLY366
3.371
|
|||||
PDB ID: 6UA5 Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free interfacial octamer reconstruction. | ||||||
Method | Electron microscopy | Resolution | 3.79 Å | Mutation | No | [1] |
PDB Sequence |
MADYLISGGT
10 SYVPDDGLTA20 QQLFNCGDGL30 TYNDFLILPG40 YIDFTADQVD50 LTSALTKKIT 60 LKTPLVSSPM70 DTVTEAGMAI80 AMALTGGIGF90 IHHNCTPEFQ100 ANEVRKVKKY 110 YPLASKDAKK242 QLLCGAAIGT252 HEDDKYRLDL262 LAQAGVDVVV272 LDSSQGNSIF 282 QINMIKYIKD292 KYPNLQVIGG302 NVVTAAQAKN312 LIDAGVDALR322 VGMGSGSICI 332 TQEVLACGRP342 QATAVYKVSE352 YARRFGVPVI362 ADGGIQNVGH372 IAKALALGAS 382 TVMMGSLLAA392 TTEAPGEYFF402 SDGIRLKKYR412 GMGSLDAMIK438 VAQGVSGAVQ 448 DKGSIHKFVP458 YLIAGIQHSC468 QDIGAKSLTQ478 VRAMMYSGEL488 KFEKRTSSAQ 498 VEGGVHSLHS508 YEKRLF
|
|||||
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IMP or .IMP2 or .IMP3 or :3IMP;style chemicals stick;color identity;select .A:68 or .A:70 or .A:303 or .A:322 or .A:324 or .A:327 or .A:328 or .A:329 or .A:330 or .A:331 or .A:333 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:389 or .A:411 or .A:413 or .A:414 or .A:415 or .A:416 or .A:441 or .A:442; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER68
3.243
MET70
3.472
ASN303
4.743
ARG322
2.865
GLY324
4.799
SER327
4.342
GLY328
3.236
SER329
2.467
ILE330
4.413
CYS331
1.626
THR333
4.753
ASP364
2.724
GLY365
3.328
GLY366
3.710
|
|||||
PDB ID: 6UAJ Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free canonical octamer reconstruction. | ||||||
Method | Electron microscopy | Resolution | 3.84 Å | Mutation | No | [1] |
PDB Sequence |
TSYVPDDGLT
19 AQQLFNCGDG29 LTYNDFLILP39 GYIDFTADQV49 DLTSALTKKI59 TLKTPLVSSP 69 MDTVTEAGMA79 IAMALTGGIG89 FIHHNCTPEF99 QANEVRKVKK109 YEQGFITDPV 119 VLSPKDRVRD129 VFEAKARHGF139 CGIPITDTGR149 MGSRLVGIIS159 SRDIDFLKEE 169 EHDCFLEEIM179 TKREDLVVAP189 AGITLKEANE199 ILQRSKKGKL209 PIVNEDDELV 219 AIIARTDLKK229 NRDYPLASKD239 AKKQLLCGAA249 IGTHEDDKYR259 LDLLAQAGVD 269 VVVLDSSQGN279 SIFQINMIKY289 IKDKYPNLQV299 IGGNVVTAAQ309 AKNLIDAGVD 319 ALRVGMGSGS329 ICITQEVLAC339 GRPQATAVYK349 VSEYARRFGV359 PVIADGGIQN 369 VGHIAKALAL379 GASTVMMGSL389 LAATTEAPGE399 YFFSDGIRLK409 KYRGMGSLDA 419 MIKVAQGVSG445 AVQDKGSIHK455 FVPYLIAGIQ465 HSCQDIGAKS475 LTQVRAMMYS 485 GELKFEKRTS495 SAQVEGGVHS505 LHSYEKRLF
|
|||||
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IMP or .IMP2 or .IMP3 or :3IMP;style chemicals stick;color identity;select .A:68 or .A:69 or .A:70 or .A:322 or .A:324 or .A:328 or .A:329 or .A:330 or .A:331 or .A:332 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:389 or .A:411 or .A:413 or .A:414 or .A:415 or .A:416 or .A:441 or .A:442; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER68
3.291
PRO69
4.935
MET70
3.488
ARG322
3.351
GLY324
4.704
GLY328
4.029
SER329
3.843
ILE330
3.594
CYS331
3.242
ILE332
4.991
ASP364
2.279
GLY365
2.897
GLY366
3.730
|
|||||
PDB ID: 6U8R Human IMPDH2 treated with ATP, IMP, and NAD+. Bent (1/4 compressed, 3/4 extended) segment reconstruction. | ||||||
Method | Electron microscopy | Resolution | 3.91 Å | Mutation | No | [1] |
PDB Sequence |
SYVPDDGLTA
20 QQLFNCGDGL30 TYNDFLILPG40 YIDFTADQVD50 LTSALTKKIT60 LKTPLVSSPM 70 DTVTEAGMAI80 AMALTGGIGF90 IHHNCTPEFQ100 ANEVRKVKKY110 EQGFITDPVV 120 LSPKDRVRDV130 FEAKARHGFC140 GIPITDTGRM150 GSRLVGIISS160 RDIDFLKEEE 170 HDCFLEEIMT180 KREDLVVAPA190 GITLKEANEI200 LQRSKKGKLP210 IVNEDDELVA 220 IIARTDLKKN230 RDYPLASKDA240 KKQLLCGAAI250 GTHEDDKYRL260 DLLAQAGVDV 270 VVLDSSQGNS280 IFQINMIKYI290 KDKYPNLQVI300 GGNVVTAAQA310 KNLIDAGVDA 320 LRVGMGSGSI330 CITQEVLACG340 RPQATAVYKV350 SEYARRFGVP360 VIADGGIQNV 370 GHIAKALALG380 ASTVMMGSLL390 AATTEAPGEY400 FFSDGIRLKK410 YRGMGSLDAM 420 IKVAQGVSGA446 VQDKGSIHKF456 VPYLIAGIQH466 SCQDIGAKSL476 TQVRAMMYSG 486 ELKFEKRTSS496 AQVEGGVHSL506 HSYEKRLF
|
|||||
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IMP or .IMP2 or .IMP3 or :3IMP;style chemicals stick;color identity;select .A:68 or .A:69 or .A:70 or .A:303 or .A:322 or .A:324 or .A:327 or .A:328 or .A:329 or .A:330 or .A:331 or .A:332 or .A:333 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:411 or .A:413 or .A:414 or .A:415 or .A:416 or .A:441 or .A:442; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER68
3.385
PRO69
4.887
MET70
3.427
ASN303
4.043
ARG322
3.247
GLY324
4.582
SER327
4.564
GLY328
3.151
SER329
2.383
ILE330
4.375
CYS331
3.195
ILE332
4.912
THR333
4.433
ASP364
2.731
|
|||||
PDB ID: 6UA2 Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (2/4 compressed, 2/4 extended) segment reconstruction. | ||||||
Method | Electron microscopy | Resolution | 4.20 Å | Mutation | No | [1] |
PDB Sequence |
SYVPDDGLTA
20 QQLFNCGDGL30 TYNDFLILPG40 YIDFTADQVD50 LTSALTKKIT60 LKTPLVSSPM 70 DTVTEAGMAI80 AMALTGGIGF90 IHHNCTPEFQ100 ANEVRKVKKY110 EQGFITDPVV 120 LSPKDRVRDV130 FEAKARHGFC140 GIPITDTGRM150 GSRLVGIISS160 RDIDFLKEEE 170 HDCFLEEIMT180 KREDLVVAPA190 GITLKEANEI200 LQRSKKGKLP210 IVNEDDELVA 220 IIARTDLKKN230 RDYPLASKDA240 KKQLLCGAAI250 GTHEDDKYRL260 DLLAQAGVDV 270 VVLDSSQGNS280 IFQINMIKYI290 KDKYPNLQVI300 GGNVVTAAQA310 KNLIDAGVDA 320 LRVGMGSGSI330 CITQEVLACG340 RPQATAVYKV350 SEYARRFGVP360 VIADGGIQNV 370 GHIAKALALG380 ASTVMMGSLL390 AATTEAPGEY400 FFSDGIRLKK410 YRGMGSLDAM 420 IKVAQGVSGA446 VQDKGSIHKF456 VPYLIAGIQH466 SCQDIGAKSL476 TQVRAMMYSG 486 ELKFEKRTSS496 AQVEGGVHSL506 HSYEKRLF
|
|||||
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IMP or .IMP2 or .IMP3 or :3IMP;style chemicals stick;color identity;select .A:68 or .A:70 or .A:322 or .A:324 or .A:327 or .A:328 or .A:329 or .A:330 or .A:331 or .A:332 or .A:333 or .A:364 or .A:365 or .A:366 or .A:367 or .A:385 or .A:386 or .A:387 or .A:388 or .A:389 or .A:411 or .A:413 or .A:414 or .A:415 or .A:416 or .A:441 or .A:442 or .A:443; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER68
2.627
MET70
4.397
ARG322
3.300
GLY324
4.849
SER327
4.371
GLY328
3.225
SER329
2.399
ILE330
3.550
CYS331
3.507
ILE332
4.894
THR333
4.828
ASP364
2.689
GLY365
3.348
GLY366
2.736
|
References | Top | ||||
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REF 1 | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife. 2020 Jan 30;9:e53243. |
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