Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86428 | Target Info | |||
| Target Name | CAAX farnesyltransferase beta (FNTB) | ||||
| Synonyms | RAS proteins prenyltransferasebeta; FTase-beta; FNTB; CAAX farnesyltransferase beta subunit | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | FNTB | ||||
| Biochemical Class | Alkyl aryl transferase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Zarnestra | Ligand Info | |||||
| Structure Description | human protein farnesyltransferase complexed with FPP and R115777 | PDB:1SA4 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
SSPVWSEPLY
24 SLRPEHARER34 LQDDSVETVT44 SIEQAKVEEK54 IQEVFSSYKF64 NHLVPRLVLQ 74 REKHFHYLKR84 GLRQLTDAYE94 CLDASRPWLC104 YWILHSLELL114 DEPIPQIVAT 124 DVCQFLELCQ134 SPEGGFGGGP144 GQYPHLAPTY154 AAVNALCIIG164 TEEAYDIINR 174 EKLLQYLYSL184 KQPDGSFLMH194 VGGEVDVRSA204 YCAASVASLT214 NIITPDLFEG 224 TAEWIARCQN234 WEGGIGGVPG244 MEAHGGYTFC254 GLAALVILKR264 ERSLNLKSLL 274 QWVTSRQMRF284 EGGFQGRCNK294 LVDGCYSFWQ304 AGLLPLLHRA314 LHAQGDPALS 324 MSHWMFHQQA334 LQEYILMCCQ344 CPAGGLLDKP354 GKSRDFYHTC364 YCLSGLSIAQ 374 HFGSGAMLHD384 VVLGVPENAL394 QPTHPVYNIG404 PDKVIQATTY414 FLQKPVPGFE 424
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| Ligand Name: L-778123 | Ligand Info | |||||
| Structure Description | Human protein farnesyltransferase complexed with L-778,123 and FPP | PDB:1S63 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [2] |
| PDB Sequence |
SSPVWSEPLY
24 SLRPEHARER34 LQDDSVETVT44 SIEQAKVEEK54 IQEVFSSYKF64 NHLVPRLVLQ 74 REKHFHYLKR84 GLRQLTDAYE94 CLDASRPWLC104 YWILHSLELL114 DEPIPQIVAT 124 DVCQFLELCQ134 SPEGGFGGGP144 GQYPHLAPTY154 AAVNALCIIG164 TEEAYDIINR 174 EKLLQYLYSL184 KQPDGSFLMH194 VGGEVDVRSA204 YCAASVASLT214 NIITPDLFEG 224 TAEWIARCQN234 WEGGIGGVPG244 MEAHGGYTFC254 GLAALVILKR264 ERSLNLKSLL 274 QWVTSRQMRF284 EGGFQGRCNK294 LVDGCYSFWQ304 AGLLPLLHRA314 LHAQGDPALS 324 MSHWMFHQQA334 LQEYILMCCQ344 CPAGGLLDKP354 GKSRDFYHTC364 YCLSGLSIAQ 374 HFGSGAMLHD384 VVLGVPENAL394 QPTHPVYNIG404 PDKVIQATTY414 FLQKPVPGFE 424
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| Ligand Name: Farnesyl | Ligand Info | |||||
| Structure Description | Protein Farnesyltransferase Complexed with a Farnesylated DDPTASACVLS Peptide Product at 1.5A Resolution | PDB:2H6F | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [3] |
| PDB Sequence |
SSPVWSEPLY
524 SLRPEHARER534 LQDDSVETVT544 SIEQAKVEEK554 IQEVFSSYKF564 NHLVPRLVLQ 574 REKHFHYLKR584 GLRQLTDAYE594 CLDASRPWLC604 YWILHSLELL614 DEPIPQIVAT 624 DVCQFLELCQ634 SPEGGFGGGP644 GQYPHLAPTY654 AAVNALCIIG664 TEEAYDIINR 674 EKLLQYLYSL684 KQPDGSFLMH694 VGGEVDVRSA704 YCAASVASLT714 NIITPDLFEG 724 TAEWIARCQN734 WEGGIGGVPG744 MEAHGGYTFC754 GLAALVILKR764 ERSLNLKSLL 774 QWVTSRQMRF784 EGGFQGRCNK794 LVDGCYSFWQ804 AGLLPLLHRA814 LHAQGDPALS 824 MSHWMFHQQA834 LQEYILMCCQ844 CPAGGLLDKP854 GKSRDFYHTC864 YCLSGLSIAQ 874 HFGSGAMLHD884 VVLGVPENAL894 QPTHPVYNIG904 PDKVIQATTY914 FLQKPVPGFE 924
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FAR or .FAR2 or .FAR3 or :3FAR;style chemicals stick;color identity;select .B:602 or .B:651 or .B:654 or .B:702 or .B:705 or .B:706 or .B:748 or .B:750 or .B:751 or .B:754 or .B:797 or .B:799 or .B:800 or .B:803 or .B:861; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: SQ-32709 | Ligand Info | |||||
| Structure Description | Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 49 | PDB:1LD8 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [4] |
| PDB Sequence |
PVWSEPLYSL
526 RPEHARERLQ536 DDSVETVTSI546 EQAKVEEKIQ556 EVFSSYKFNH566 LVPRLVLQRE 576 KHFHYLKRGL586 RQLTDAYECL596 DASRPWLCYW606 ILHSLELLDE616 PIPQIVATDV 626 CQFLELCQSP636 EGGFGGGPGQ646 YPHLAPTYAA656 VNALCIIGTE666 EAYDIINREK 676 LLQYLYSLKQ686 PDGSFLMHVG696 GEVDVRSAYC706 AASVASLTNI716 ITPDLFEGTA 726 EWIARCQNWE736 GGIGGVPGME746 AHGGYTFCGL756 AALVILKRER766 SLNLKSLLQW 776 VTSRQMRFEG786 GFQGRCNKLV796 DGCYSFWQAG806 LLPLLHRALH816 AQGDPALSMS 826 HWMFHQQALQ836 EYILMCCQCP846 AGGLLDKPGK856 SRDFYHTCYC866 LSGLSIAQHF 876 GSGAMLHDVV886 LGVPENALQP896 THPVYNIGPD906 KVIQATTYFL916 QKPVPGF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FPP or .FPP2 or .FPP3 or :3FPP;style chemicals stick;color identity;select .B:602 or .B:651 or .B:654 or .B:702 or .B:705 or .B:706 or .B:748 or .B:750 or .B:751 or .B:754 or .B:790 or .B:791 or .B:794 or .B:795 or .B:797 or .B:800 or .B:803 or .B:861; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: L-739750 | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750 | PDB:1JCQ | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [5] |
| PDB Sequence |
SSPVWSEPLY
24 SLRPEHARER34 LQDDSVETVT44 SIEQAKVEEK54 IQEVFSSYKF64 NHLVPRLVLQ 74 REKHFHYLKR84 GLRQLTDAYE94 CLDASRPWLC104 YWILHSLELL114 DEPIPQIVAT 124 DVCQFLELCQ134 SPEGGFGGGP144 GQYPHLAPTY154 AAVNALCIIG164 TEEAYDIINR 174 EKLLQYLYSL184 KQPDGSFLMH194 VGGEVDVRSA204 YCAASVASLT214 NIITPDLFEG 224 TAEWIARCQN234 WEGGIGGVPG244 MEAHGGYTFC254 GLAALVILKR264 ERSLNLKSLL 274 QWVTSRQMRF284 EGGFQGRCNK294 LVDGCYSFWQ304 AGLLPLLHRA314 LHAQGDPALS 324 MSHWMFHQQA334 LQEYILMCCQ344 CPAGGLLDKP354 GKSRDFYHTC364 YCLSGLSIAQ 374 HFGSGAMLHD384 VVLGVPENAL394 QPTHPVYNIG404 PDKVIQATTY414 FLQKPVPGFE 424
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .739 or .7392 or .7393 or :3739;style chemicals stick;color identity;select .B:96 or .B:98 or .B:99 or .B:102 or .B:106 or .B:149 or .B:151 or .B:152 or .B:198 or .B:202 or .B:297 or .B:299 or .B:300 or .B:361 or .B:362; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (20s)-19,20,21,22-Tetrahydro-19-oxo-5h-18,20-ethano-12,14-etheno-6,10-metheno-18h-benz[d]imidazo[4,3-k][1,6,9,12]oxatriaza-cyclooctadecosine-9-carbonitrile | Ligand Info | |||||
| Structure Description | Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 49 | PDB:1LD8 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [4] |
| PDB Sequence |
PVWSEPLYSL
526 RPEHARERLQ536 DDSVETVTSI546 EQAKVEEKIQ556 EVFSSYKFNH566 LVPRLVLQRE 576 KHFHYLKRGL586 RQLTDAYECL596 DASRPWLCYW606 ILHSLELLDE616 PIPQIVATDV 626 CQFLELCQSP636 EGGFGGGPGQ646 YPHLAPTYAA656 VNALCIIGTE666 EAYDIINREK 676 LLQYLYSLKQ686 PDGSFLMHVG696 GEVDVRSAYC706 AASVASLTNI716 ITPDLFEGTA 726 EWIARCQNWE736 GGIGGVPGME746 AHGGYTFCGL756 AALVILKRER766 SLNLKSLLQW 776 VTSRQMRFEG786 GFQGRCNKLV796 DGCYSFWQAG806 LLPLLHRALH816 AQGDPALSMS 826 HWMFHQQALQ836 EYILMCCQCP846 AGGLLDKPGK856 SRDFYHTCYC866 LSGLSIAQHF 876 GSGAMLHDVV886 LGVPENALQP896 THPVYNIGPD906 KVIQATTYFL916 QKPVPGF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U49 or .U492 or .U493 or :3U49;style chemicals stick;color identity;select .B:596 or .B:599 or .B:602 or .B:606 or .B:702 or .B:797 or .B:799 or .B:800 or .B:803 or .B:861 or .B:862; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Methyl N-{(3s)-1-[(1-Methyl-1h-Imidazol-5-Yl)methyl]-6-Phenyl-1,2,3,4-Tetrahydroquinolin-3-Yl}-N-[(1-Methyl-1h-Imidazol-4-Yl)sulfonyl]glycinate | Ligand Info | |||||
| Structure Description | Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution | PDB:2IEJ | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [6] |
| PDB Sequence |
SSPVWSEPLY
524 SLRPEHARER534 LQDDSVETVT544 SIEQAKVEEK554 IQEVFSSYKF564 NHLVPRLVLQ 574 REKHFHYLKR584 GLRQLTDAYE594 CLDASRPWLC604 YWILHSLELL614 DEPIPQIVAT 624 DVCQFLELCQ634 SPEGGFGGGP644 GQYPHLAPTY654 AAVNALCIIG664 TEEAYDIINR 674 EKLLQYLYSL684 KQPDGSFLMH694 VGGEVDVRSA704 YCAASVASLT714 NIITPDLFEG 724 TAEWIARCQN734 WEGGIGGVPG744 MEAHGGYTFC754 GLAALVILKR764 ERSLNLKSLL 774 QWVTSRQMRF784 EGGFQGRCNK794 LVDGCYSFWQ804 AGLLPLLHRA814 LHAQGDPALS 824 MSHWMFHQQA834 LQEYILMCCQ844 CPAGGLLDKP854 GKSRDFYHTC864 YCLSGLSIAQ 874 HFGSGAMLHD884 VVLGVPENAL894 QPTHPVYNIG904 PDKVIQATTY914 FLQKPVPGFE 924
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .S48 or .S482 or .S483 or :3S48;style chemicals stick;color identity;select .B:593 or .B:596 or .B:602 or .B:603 or .B:606 or .B:702 or .B:797 or .B:799 or .B:803 or .B:852 or .B:859 or .B:860 or .B:861 or .B:862 or .B:865; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Tert-Butyl 4-({(2-{(4-Cyanophenyl)[(1-Methyl-1h-Imidazol-5-Yl)methyl]amino}ethyl)[(2-Methylphenyl)sulfonyl]amino}methyl)piperidine-1-Carboxylate | Ligand Info | |||||
| Structure Description | Protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5 | PDB:3E37 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [7] |
| PDB Sequence |
SSPVWSEPLY
26 SLRPEHARER36 LQDDSVETVT46 SIEQAKVEEK56 IQEVFSSYKF66 NHLVPRLVLQ 76 REKHFHYLKR86 GLRQLTDAYE96 CLDASRPWLC106 YWILHSLELL116 DEPIPQIVAT 126 DVCQFLELCQ136 SPEGGFGGGP146 GQYPHLAPTY156 AAVNALCIIG166 TEEAYDIINR 176 EKLLQYLYSL186 KQPDGSFLMH196 VGGEVDVRSA206 YCAASVASLT216 NIITPDLFEG 226 TAEWIARCQN236 WEGGIGGVPG246 MEAHGGYTFC256 GLAALVILKR266 ERSLNLKSLL 276 QWVTSRQMRF286 EGGFQGRCNK296 LVDGCYSFWQ306 AGLLPLLHRA316 LHAQGDPALS 326 MSHWMFHQQA336 LQEYILMCCQ346 CPAGGLLDKP356 GKSRDFYHTC366 YCLSGLSIAQ 376 HFGSGAMLHD386 VVLGVPENAL396 QPTHPVYNIG406 PDKVIQATTY416 FLQKPVPGFE 426
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ED5 or .ED52 or .ED53 or :3ED5;style chemicals stick;color identity;select .B:98 or .B:104 or .B:108 or .B:153 or .B:156 or .B:204 or .B:207 or .B:208 or .B:250 or .B:252 or .B:253 or .B:256 or .B:299 or .B:301 or .B:302 or .B:305 or .B:354 or .B:361 or .B:362 or .B:363 or .B:364 or .B:367; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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LEU98
3.960
TRP104
3.036
TRP108
3.718
ALA153
3.761
TYR156
3.602
ARG204
3.544
TYR207
3.736
CYS208
3.590
HIS250
4.131
GLY252
3.256
TYR253
3.838
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| Ligand Name: [(3,7,11-Trimethyl-dodeca-2,6,10-trienyloxycarbamoyl)-methyl]-phosphonic acid | Ligand Info | |||||
| Structure Description | Protein Farnesyltransferase Complexed with a Rap2a Peptide Substrate and a FPP Analog at 1.8A Resolution | PDB:1TN6 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [8] |
| PDB Sequence |
SSPVWSEPLY
524 SLRPEHARER534 LQDDSVETVT544 SIEQAKVEEK554 IQEVFSSYKF564 NHLVPRLVLQ 574 REKHFHYLKR584 GLRQLTDAYE594 CLDASRPWLC604 YWILHSLELL614 DEPIPQIVAT 624 DVCQFLELCQ634 SPEGGFGGGP644 GQYPHLAPTY654 AAVNALCIIG664 TEEAYDIINR 674 EKLLQYLYSL684 KQPDGSFLMH694 VGGEVDVRSA704 YCAASVASLT714 NIITPDLFEG 724 TAEWIARCQN734 WEGGIGGVPG744 MEAHGGYTFC754 GLAALVILKR764 ERSLNLKSLL 774 QWVTSRQMRF784 EGGFQGRCNK794 LVDGCYSFWQ804 AGLLPLLHRA814 LHAQGDPALS 824 MSHWMFHQQA834 LQEYILMCCQ844 CPAGGLLDKP854 GKSRDFYHTC864 YCLSGLSIAQ 874 HFGSGAMLHD884 VVLGVPENAL894 QPTHPVYNIG904 PDKVIQATTY914 FLQKPVPGFE 924
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FII or .FII2 or .FII3 or :3FII;style chemicals stick;color identity;select .B:602 or .B:654 or .B:702 or .B:705 or .B:706 or .B:748 or .B:750 or .B:751 or .B:754 or .B:790 or .B:791 or .B:794 or .B:795 or .B:800 or .B:803 or .B:861; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Geran-8-YL geran | Ligand Info | |||||
| Structure Description | W102T Protein Farnesyltransferase Mutant Complexed with a Geranylgeranylated DDPTASACVLS Peptide Product at 1.85A Resolution | PDB:2H6G | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | Yes | [3] |
| PDB Sequence |
SSPVWSEPLY
524 SLRPEHARER534 LQDDSVETVT544 SIEQAKVEEK554 IQEVFSSYKF564 NHLVPRLVLQ 574 REKHFHYLKR584 GLRQLTDAYE594 CLDASRPTLC604 YWILHSLELL614 DEPIPQIVAT 624 DVCQFLELCQ634 SPEGGFGGGP644 GQYPHLAPTY654 AAVNALCIIG664 TEEAYDIINR 674 EKLLQYLYSL684 KQPDGSFLMH694 VGGEVDVRSA704 YCAASVASLT714 NIITPDLFEG 724 TAEWIARCQN734 WEGGIGGVPG744 MEAHGGYTFC754 GLAALVILKR764 ERSLNLKSLL 774 QWVTSRQMRF784 EGGFQGRCNK794 LVDGCYSFWQ804 AGLLPLLHRA814 LHAQGDPALS 824 MSHWMFHQQA834 LQEYILMCCQ844 CPAGGLLDKP854 GKSRDFYHTC864 YCLSGLSIAQ 874 HFGSGAMLHD884 VVLGVPENAL894 QPTHPVYNIG904 PDKVIQATTY914 FLQKPVPGFE 924
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GER or .GER2 or .GER3 or :3GER;style chemicals stick;color identity;select .B:602 or .B:605 or .B:606 or .B:651 or .B:652 or .B:654 or .B:655 or .B:693 or .B:702 or .B:705 or .B:706 or .B:748 or .B:750 or .B:751 or .B:754 or .B:797 or .B:799 or .B:800 or .B:803 or .B:861 or .B:862 or .B:865; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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THR602
3.682
TYR605
4.213
TRP606
3.304
ALA651
3.216
PRO652
4.977
TYR654
3.287
ALA655
4.017
MET693
4.922
ARG702
3.436
TYR705
3.788
CYS706
3.711
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (5S,18R)-31-oxo-20-oxa-2,6,11,13-tetrazahexacyclo[19.6.2.12,5.115,19.09,13.024,28]hentriaconta-1(27),9,11,15,21(29),22,24(28),25-octaene-18-carbonitrile | Ligand Info | |||||
| Structure Description | Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 66 | PDB:1LD7 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [4] |
| PDB Sequence |
PVWSEPLYSL
526 RPEHARERLQ536 DDSVETVTSI546 EQAKVEEKIQ556 EVFSSYKFNH566 LVPRLVLQRE 576 KHFHYLKRGL586 RQLTDAYECL596 DASRPWLCYW606 ILHSLELLDE616 PIPQIVATDV 626 CQFLELCQSP636 EGGFGGGPGQ646 YPHLAPTYAA656 VNALCIIGTE666 EAYDIINREK 676 LLQYLYSLKQ686 PDGSFLMHVG696 GEVDVRSAYC706 AASVASLTNI716 ITPDLFEGTA 726 EWIARCQNWE736 GGIGGVPGME746 AHGGYTFCGL756 AALVILKRER766 SLNLKSLLQW 776 VTSRQMRFEG786 GFQGRCNKLV796 DGCYSFWQAG806 LLPLLHRALH816 AQGDPALSMS 826 HWMFHQQALQ836 EYILMCCQCP846 AGGLLDKPGK856 SRDFYHTCYC866 LSGLSIAQHF 876 GSGAMLHDVV886 LGVPENALQP896 THPVYNIGPD906 KVIQATTYFL916 QKPVPGF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U66 or .U662 or .U663 or :3U66;style chemicals stick;color identity;select .B:596 or .B:599 or .B:602 or .B:606 or .B:702 or .B:797 or .B:799 or .B:800 or .B:803 or .B:861 or .B:862; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-YL)-phenoxy]-4-[1-amino-1-(1-methyl-1H-imidizol-5-YL)-ethyl]-benzonitrile | Ligand Info | |||||
| Structure Description | Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a | PDB:1MZC | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [9] |
| PDB Sequence |
PVWSEPLYSL
526 RPEHARERLQ536 DDSVETVTSI546 EQAKVEEKIQ556 EVFSSYKFNH566 LVPRLVLQRE 576 KHFHYLKRGL586 RQLTDAYECL596 DASRPWLCYW606 ILHSLELLDE616 PIPQIVATDV 626 CQFLELCQSP636 EGGFGGGPGQ646 YPHLAPTYAA656 VNALCIIGTE666 EAYDIINREK 676 LLQYLYSLKQ686 PDGSFLMHVG696 GEVDVRSAYC706 AASVASLTNI716 ITPDLFEGTA 726 EWIARCQNWE736 GGIGGVPGME746 AHGGYTFCGL756 AALVILKRER766 SLNLKSLLQW 776 VTSRQMRFEG786 GFQGRCNKLV796 DGCYSFWQAG806 LLPLLHRALH816 AQGDPALSMS 826 HWMFHQQALQ836 EYILMCCQCP846 AGGLLDKPGK856 SRDFYHTCYC866 LSGLSIAQHF 876 GSGAMLHDVV886 LGVPENALQP896 THPVYNIGPD906 KVIQATTYFL916 QKPVPGF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BNE or .BNE2 or .BNE3 or :3BNE;style chemicals stick;color identity;select .B:596 or .B:599 or .B:602 or .B:606 or .B:651 or .B:702 or .B:797 or .B:799 or .B:800 or .B:803 or .B:861 or .B:862 or .B:865; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-({3-[3-(1h-Imidazol-1-Yl)propyl]-5-Methyl-5-(1-Naphthyl)-2,4-Dioxoimidazolidin-1-Yl}methyl)benzonitrile | Ligand Info | |||||
| Structure Description | Crystal Structure Of Human Protein Farnesyltransferase Complexed With Farnesyl Diphosphate and hydantoin derivative | PDB:2F0Y | ||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [10] |
| PDB Sequence |
EPLYSLRPEH
30 ARERLQDDSV40 ETVTSIEQAK50 VEEKIQEVFS60 SYKRLVLQRE76 KHFHYLKRGL 86 RQLTDAYECL96 DASRPWLCYW106 ILHSLELLDE116 PIPQIVATDV126 CQFLELCQSP 136 EGGFGGGPGQ146 YPHLAPTYAA156 VNALCIIGTE166 EAYDIINREK176 LLQYLYSLKQ 186 PDGSFLMHVG196 GEVDVRSAYC206 AASVASLTNI216 ITPDLFEGTA226 EWIARCQNWE 236 GGIGGVPGME246 AHGGYTFCGL256 AALVILKRER266 SLNLKSLLQW276 VTSRQMRFEG 286 GFQGRCNKLV296 DGCYSFWQAG306 LLPLLHRALH316 AQGDPALSMS326 HWMFHQQALQ 336 EYILMCCQCP346 AGGLLDKPGK356 SRDFYHTCYC366 LSGLSIAQHF376 GSGAMLHDVV 386 LGVPENALQP396 THPVYNIGPD406 KVIQATTYFL416 QKPVP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3MN or .3MN2 or .3MN3 or :33MN;style chemicals stick;color identity;select .B:93 or .B:96 or .B:99 or .B:102 or .B:103 or .B:106 or .B:297 or .B:299 or .B:300 or .B:303 or .B:359 or .B:360 or .B:361 or .B:362; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity. Biochemistry. 2004 Jun 8;43(22):6877-84. | ||||
| REF 2 | Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes. Biochemistry. 2004 Jul 20;43(28):9000-8. | ||||
| REF 3 | Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry. 2006 Aug 15;45(32):9746-55. | ||||
| REF 4 | 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. J Med Chem. 2002 Jun 6;45(12):2388-409. | ||||
| REF 5 | The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12948-53. | ||||
| REF 6 | Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol Biochem Parasitol. 2007 Mar;152(1):66-71. | ||||
| REF 7 | Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem Biol. 2009 Feb 27;16(2):181-92. | ||||
| REF 8 | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J Mol Biol. 2004 Oct 15;343(2):417-33. | ||||
| REF 9 | Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. J Med Chem. 2003 Jul 3;46(14):2973-84. | ||||
| REF 10 | Crystal Structure Of Human Protein Farnesyltransferase Complexed With Farnesyl Diphosphate and hydantoin derivative | ||||
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