Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86428 | Target Info | |||
| Target Name | CAAX farnesyltransferase beta (FNTB) | ||||
| Synonyms | RAS proteins prenyltransferasebeta; FTase-beta; FNTB; CAAX farnesyltransferase beta subunit | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | FNTB | ||||
| Biochemical Class | Alkyl aryl transferase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | [(3,7,11-Trimethyl-dodeca-2,6,10-trienyloxycarbamoyl)-methyl]-phosphonic acid | Ligand Info | |||
| Canonical SMILES | CC(=CCCC(=CCCC(=CCONC(=O)CP(=O)(O)O)C)C)C | ||||
| InChI | 1S/C17H30NO5P/c1-14(2)7-5-8-15(3)9-6-10-16(4)11-12-23-18-17(19)13-24(20,21)22/h7,9,11H,5-6,8,10,12-13H2,1-4H3,(H,18,19)(H2,20,21,22)/b15-9+,16-11+ | ||||
| InChIKey | JAOBYUCYSAOLHS-XGGJEREUSA-N | ||||
| PubChem Compound ID | 445015 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 1TN6 Protein Farnesyltransferase Complexed with a Rap2a Peptide Substrate and a FPP Analog at 1.8A Resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [1] |
| PDB Sequence |
SSPVWSEPLY
524 SLRPEHARER534 LQDDSVETVT544 SIEQAKVEEK554 IQEVFSSYKF564 NHLVPRLVLQ 574 REKHFHYLKR584 GLRQLTDAYE594 CLDASRPWLC604 YWILHSLELL614 DEPIPQIVAT 624 DVCQFLELCQ634 SPEGGFGGGP644 GQYPHLAPTY654 AAVNALCIIG664 TEEAYDIINR 674 EKLLQYLYSL684 KQPDGSFLMH694 VGGEVDVRSA704 YCAASVASLT714 NIITPDLFEG 724 TAEWIARCQN734 WEGGIGGVPG744 MEAHGGYTFC754 GLAALVILKR764 ERSLNLKSLL 774 QWVTSRQMRF784 EGGFQGRCNK794 LVDGCYSFWQ804 AGLLPLLHRA814 LHAQGDPALS 824 MSHWMFHQQA834 LQEYILMCCQ844 CPAGGLLDKP854 GKSRDFYHTC864 YCLSGLSIAQ 874 HFGSGAMLHD884 VVLGVPENAL894 QPTHPVYNIG904 PDKVIQATTY914 FLQKPVPGFE 924
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| PDB ID: 2IEJ Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [2] |
| PDB Sequence |
SSPVWSEPLY
524 SLRPEHARER534 LQDDSVETVT544 SIEQAKVEEK554 IQEVFSSYKF564 NHLVPRLVLQ 574 REKHFHYLKR584 GLRQLTDAYE594 CLDASRPWLC604 YWILHSLELL614 DEPIPQIVAT 624 DVCQFLELCQ634 SPEGGFGGGP644 GQYPHLAPTY654 AAVNALCIIG664 TEEAYDIINR 674 EKLLQYLYSL684 KQPDGSFLMH694 VGGEVDVRSA704 YCAASVASLT714 NIITPDLFEG 724 TAEWIARCQN734 WEGGIGGVPG744 MEAHGGYTFC754 GLAALVILKR764 ERSLNLKSLL 774 QWVTSRQMRF784 EGGFQGRCNK794 LVDGCYSFWQ804 AGLLPLLHRA814 LHAQGDPALS 824 MSHWMFHQQA834 LQEYILMCCQ844 CPAGGLLDKP854 GKSRDFYHTC864 YCLSGLSIAQ 874 HFGSGAMLHD884 VVLGVPENAL894 QPTHPVYNIG904 PDKVIQATTY914 FLQKPVPGFE 924
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J Mol Biol. 2004 Oct 15;343(2):417-33. | ||||
| REF 2 | Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol Biochem Parasitol. 2007 Mar;152(1):66-71. | ||||
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