Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86428 | Target Info | |||
| Target Name | CAAX farnesyltransferase beta (FNTB) | ||||
| Synonyms | RAS proteins prenyltransferasebeta; FTase-beta; FNTB; CAAX farnesyltransferase beta subunit | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | FNTB | ||||
| Biochemical Class | Alkyl aryl transferase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Geran-8-YL geran | Ligand Info | |||
| Canonical SMILES | CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C | ||||
| InChI | 1S/C20H34/c1-7-18(4)12-9-14-20(6)16-10-15-19(5)13-8-11-17(2)3/h7,11,14-15H,8-10,12-13,16H2,1-6H3/b18-7+,19-15+,20-14+ | ||||
| InChIKey | HSOYJGBJQAKCNA-CAIKYXSQSA-N | ||||
| PubChem Compound ID | 446073 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 2H6G W102T Protein Farnesyltransferase Mutant Complexed with a Geranylgeranylated DDPTASACVLS Peptide Product at 1.85A Resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | Yes | [1] |
| PDB Sequence |
SSPVWSEPLY
524 SLRPEHARER534 LQDDSVETVT544 SIEQAKVEEK554 IQEVFSSYKF564 NHLVPRLVLQ 574 REKHFHYLKR584 GLRQLTDAYE594 CLDASRPTLC604 YWILHSLELL614 DEPIPQIVAT 624 DVCQFLELCQ634 SPEGGFGGGP644 GQYPHLAPTY654 AAVNALCIIG664 TEEAYDIINR 674 EKLLQYLYSL684 KQPDGSFLMH694 VGGEVDVRSA704 YCAASVASLT714 NIITPDLFEG 724 TAEWIARCQN734 WEGGIGGVPG744 MEAHGGYTFC754 GLAALVILKR764 ERSLNLKSLL 774 QWVTSRQMRF784 EGGFQGRCNK794 LVDGCYSFWQ804 AGLLPLLHRA814 LHAQGDPALS 824 MSHWMFHQQA834 LQEYILMCCQ844 CPAGGLLDKP854 GKSRDFYHTC864 YCLSGLSIAQ 874 HFGSGAMLHD884 VVLGVPENAL894 QPTHPVYNIG904 PDKVIQATTY914 FLQKPVPGFE 924
|
|||||
|
|
THR602
3.682
TYR605
4.213
TRP606
3.304
ALA651
3.216
PRO652
4.977
TYR654
3.287
ALA655
4.017
MET693
4.922
ARG702
3.436
TYR705
3.788
CYS706
3.711
|
|||||
| PDB ID: 2H6I W102T/Y365F Protein Farnesyltransferase Double Mutant Complexed with a Geranylgeranylated DDPTASACVLS Peptide Product at 3.0A | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
SSPVWSEPLY
524 SLRPEHARER534 LQDDSVETVT544 SIEQAKVEEK554 IQEVFSSYKF564 NHLVPRLVLQ 574 REKHFHYLKR584 GLRQLTDAYE594 CLDASRPTLC604 YWILHSLELL614 DEPIPQIVAT 624 DVCQFLELCQ634 SPEGGFGGGP644 GQYPHLAPTY654 AAVNALCIIG664 TEEAYDIINR 674 EKLLQYLYSL684 KQPDGSFLMH694 VGGEVDVRSA704 YCAASVASLT714 NIITPDLFEG 724 TAEWIARCQN734 WEGGIGGVPG744 MEAHGGYTFC754 GLAALVILKR764 ERSLNLKSLL 774 QWVTSRQMRF784 EGGFQGRCNK794 LVDGCYSFWQ804 AGLLPLLHRA814 LHAQGDPALS 824 MSHWMFHQQA834 LQEYILMCCQ844 CPAGGLLDKP854 GKSRDFYHTC864 FCLSGLSIAQ 874 HFGSGAMLHD884 VVLGVPENAL894 QPTHPVYNIG904 PDKVIQATTY914 FLQKPVPGFE 924
|
|||||
|
|
THR602
3.213
TYR605
3.743
TRP606
3.897
ALA651
3.660
TYR654
3.451
ALA655
3.871
MET693
4.374
ARG702
3.447
TYR705
4.060
CYS706
4.011
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry. 2006 Aug 15;45(32):9746-55. | ||||
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