Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T65239 Target Info
Target Name Ammonium transporter Rh type A (RHAG)
Synonyms Rhesus blood group-associated glycoprotein; Rhesus blood group-associated ammonia channel; Rhesus blood group family type A glycoprotein; Rh50A; Rh type A glycoprotein; Rh family type A glycoprotein; RH50; Erythrocyte plasma membrane 50 kDa glycoprotein; Erythrocyte membrane glycoprotein Rh50; CD241
Target Type Literature-reported Target
Gene Name RHAG
UniProt ID
RHAG_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cholesterol Ligand Info
Structure Description Local refinement of RhAG-RhCE-ANK1(AR1-5), from consensus refinement of all classes PDB:7UZQ
Method Electron microscopy Resolution 2.17 Å Mutation No [1]
PDB Sequence
MRFTFPLMAI
10
VLEIAMIVLF
20
GLFVEYFELY
51
PLFQDVHVMI
61
FVGFGFLMTF
71

LKKYGFSSVG
81
INLLVAALGL
91
QWGTIVQGIL
101
QSQGQKFNIG
111
IKNMINADFS
121

AATVLISFGA
131
VLGKTSPTQM
141
LIMTILEIVF
151
FAHNEYLVSE
161
IFKASDIGAS
171

MTIHAFGAYF
181
GLAVAGILYR
191
SGLRKGHENE
201
ESAYYSDLFA
211
MIGTLFLWMF
221

WPSFNSAIAE
231
PGDKQCRAIV
241
NTYFSLAACV
251
LTAFAFSSLV
261
EHRGKLNMVH
271

IQNATLAGGV
281
AVGTCADMAI
291
HPFGSMIIGS
301
IAGMVSVLGY
311
KFLTPLFTTK
321

LRIHDTCGVH
331
NLHGLPGVVG
341
GLAGIVAVAM
351
GASNTSMAMQ
361
AAALGSSIGT
371

AVVGGLMTGL
381
ILKLPLWGQP
391
SDQNCYDDSV
401
YWKVPKTR
Residue
Distance (Å)
ALA179
4.859
TYR180
2.431
PHE181
4.904
LEU183
2.287
ALA184
2.675
GLY187
2.380
ILE188
2.324
TYR190
2.544
CYS286
3.036
ALA290
3.416
ILE291
2.353
HIS292
2.534
PHE294
2.227
GLY295
3.097
ILE298
2.404
ILE299
3.003
ILE302
2.758
PHE318
3.483
Residue
Distance (Å)
LEU322
2.857
ARG323
2.303
ILE324
2.239
HIS331
4.957
VAL339
4.800
VAL340
2.275
LEU343
2.359
ALA344
2.364
GLY345
4.930
VAL347
2.279
ALA348
2.280
MET351
2.643
ALA353
2.475
ILE369
4.852
VAL373
2.249
LEU377
2.303
LYS384
3.928
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Architecture of the human erythrocyte ankyrin-1 complex. Nat Struct Mol Biol. 2022 Jul;29(7):706-718.

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