Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T65239 | Target Info | |||
| Target Name | Ammonium transporter Rh type A (RHAG) | ||||
| Synonyms | Rhesus blood group-associated glycoprotein; Rhesus blood group-associated ammonia channel; Rhesus blood group family type A glycoprotein; Rh50A; Rh type A glycoprotein; Rh family type A glycoprotein; RH50; Erythrocyte plasma membrane 50 kDa glycoprotein; Erythrocyte membrane glycoprotein Rh50; CD241 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | RHAG | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C | ||||
| InChI | 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 | ||||
| InChIKey | HVYWMOMLDIMFJA-DPAQBDIFSA-N | ||||
| PubChem Compound ID | 5997 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7UZQ Local refinement of RhAG-RhCE-ANK1(AR1-5), from consensus refinement of all classes | ||||||
| Method | Electron microscopy | Resolution | 2.17 Å | Mutation | No | [1] |
| PDB Sequence |
MRFTFPLMAI
10 VLEIAMIVLF20 GLFVEYFELY51 PLFQDVHVMI61 FVGFGFLMTF71 LKKYGFSSVG 81 INLLVAALGL91 QWGTIVQGIL101 QSQGQKFNIG111 IKNMINADFS121 AATVLISFGA 131 VLGKTSPTQM141 LIMTILEIVF151 FAHNEYLVSE161 IFKASDIGAS171 MTIHAFGAYF 181 GLAVAGILYR191 SGLRKGHENE201 ESAYYSDLFA211 MIGTLFLWMF221 WPSFNSAIAE 231 PGDKQCRAIV241 NTYFSLAACV251 LTAFAFSSLV261 EHRGKLNMVH271 IQNATLAGGV 281 AVGTCADMAI291 HPFGSMIIGS301 IAGMVSVLGY311 KFLTPLFTTK321 LRIHDTCGVH 331 NLHGLPGVVG341 GLAGIVAVAM351 GASNTSMAMQ361 AAALGSSIGT371 AVVGGLMTGL 381 ILKLPLWGQP391 SDQNCYDDSV401 YWKVPKTR
|
|||||
|
|
ALA179
4.859
TYR180
2.431
PHE181
4.904
LEU183
2.287
ALA184
2.675
GLY187
2.380
ILE188
2.324
TYR190
2.544
CYS286
3.036
ALA290
3.416
ILE291
2.353
HIS292
2.534
PHE294
2.227
GLY295
3.097
ILE298
2.404
ILE299
3.003
ILE302
2.758
PHE318
3.483
|
|||||
| PDB ID: 8CSX Local refinement of RhAG/CE trimer in class 2 of erythrocyte ankyrin-1 complex | ||||||
| Method | Electron microscopy | Resolution | 2.40 Å | Mutation | No | [1] |
| PDB Sequence |
MRFTFPLMAI
10 VLEIAMIVLF20 GLFVEYFELY51 PLFQDVHVMI61 FVGFGFLMTF71 LKKYGFSSVG 81 INLLVAALGL91 QWGTIVQGIL101 QSQGQKFNIG111 IKNMINADFS121 AATVLISFGA 131 VLGKTSPTQM141 LIMTILEIVF151 FAHNEYLVSE161 IFKASDIGAS171 MTIHAFGAYF 181 GLAVAGILYR191 SGLRKGHENE201 ESAYYSDLFA211 MIGTLFLWMF221 WPSFNSAIAE 231 PGDKQCRAIV241 NTYFSLAACV251 LTAFAFSSLV261 EHRGKLNMVH271 IQNATLAGGV 281 AVGTCADMAI291 HPFGSMIIGS301 IAGMVSVLGY311 KFLTPLFTTK321 LRIHDTCGVH 331 NLHGLPGVVG341 GLAGIVAVAM351 GASNTSMAMQ361 AAALGSSIGT371 AVVGGLMTGL 381 ILKLPLWGQP391 SDQNCYDDSV401 YWKVPKTR
|
|||||
|
|
TYR180
3.778
LEU183
3.735
ALA184
3.607
GLY187
3.333
ILE188
3.656
TYR190
4.065
ALA290
3.972
ILE291
3.858
HIS292
2.912
PHE294
3.449
GLY295
4.566
ILE298
4.251
ILE299
3.677
ILE302
3.630
|
|||||
| PDB ID: 7V0S Local refinement of RhAG/CE trimer, class 1 of erythrocyte ankyrin-1 complex | ||||||
| Method | Electron microscopy | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
MRFTFPLMAI
10 VLEIAMIVLF20 GLFVEYFELY51 PLFQDVHVMI61 FVGFGFLMTF71 LKKYGFSSVG 81 INLLVAALGL91 QWGTIVQGIL101 QSQGQKFNIG111 IKNMINADFS121 AATVLISFGA 131 VLGKTSPTQM141 LIMTILEIVF151 FAHNEYLVSE161 IFKASDIGAS171 MTIHAFGAYF 181 GLAVAGILYR191 SGLRKGHENE201 ESAYYSDLFA211 MIGTLFLWMF221 WPSFNSAIAE 231 PGDKQCRAIV241 NTYFSLAACV251 LTAFAFSSLV261 EHRGKLNMVH271 IQNATLAGGV 281 AVGTCADMAI291 HPFGSMIIGS301 IAGMVSVLGY311 KFLTPLFTTK321 LRIHDTCGVH 331 NLHGLPGVVG341 GLAGIVAVAM351 GASNTSMAMQ361 AAALGSSIGT371 AVVGGLMTGL 381 ILKLPLWGQP391 SDQNCYDDSV401 YWKVPKTR
|
|||||
|
|
TYR180
3.406
LEU183
3.686
ALA184
3.499
GLY187
3.660
ILE188
3.822
TYR190
3.893
ALA290
3.894
ILE291
3.332
HIS292
3.048
PHE294
3.541
GLY295
4.435
ILE298
3.786
ILE299
4.240
ILE302
3.713
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Architecture of the human erythrocyte ankyrin-1 complex. Nat Struct Mol Biol. 2022 Jul;29(7):706-718. | ||||
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