Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T58679 Target Info
Target Name Polyadenylate-binding protein 1 (PABPC1)
Synonyms PABP-1; Poly(A)-binding protein 1
Target Type Clinical trial Target
Gene Name PABPC1
UniProt ID
PABP1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Adenosine monophosphate Ligand Info
Structure Description X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA PDB:1CVJ
Method X-ray diffraction Resolution 2.60 Å Mutation No [1]
PDB Sequence
ASLYVGDLHP
20
DVTEAMLYEK
30
FSPAGPILSI
40
RVCRDMITRR
50
SLGYAYVNFQ
60

QPADAERALD
70
TMNFDVIKGK
80
PVRIMWSQRD
90
PSLRKSGVGN
100
IFIKNLDKSI
110

DNKALYDTFS
120
AFGNILSCKV
130
VCDENGSKGY
140
GFVHFETQEA
150
AERAIEKMNG
160

MLLNDRKVFV
170
GRFKSRKER
Residue
Distance (Å)
SER12
2.977
SER39
4.679
ARG41
4.284
Residue
Distance (Å)
ASN58
3.659
SER87
4.654
ARG89
4.514
Ligand Name: Tilarginine Ligand Info
Structure Description Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455) PDB:5DX1
Method X-ray diffraction Resolution 1.93 Å Mutation Yes [2]
PDB Sequence
GAIRPAAP
Residue
Distance (Å)
ALA10
3.654
Residue
Distance (Å)
PRO11
1.331
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Ligand Name: Sinefungin Ligand Info
Structure Description Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455) PDB:5DX1
Method X-ray diffraction Resolution 1.93 Å Mutation Yes [2]
PDB Sequence
GAIRPAAP
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Residue
Distance (Å)
ARG7
3.005
Residue
Distance (Å)
Ligand Name: (2~{r},3~{r},4~{s},5~{r})-2-(6-Aminopurin-9-Yl)-5-Propyl-Oxolane-3,4-Diol Ligand Info
Structure Description Crystal structure of mouse CARM1 in complex with ligand P1C3s PDB:5LGP
Method X-ray diffraction Resolution 2.04 Å Mutation Yes [3]
PDB Sequence
QNMPGAIRPA
3
A
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Residue
Distance (Å)
ILE0
4.568
Residue
Distance (Å)
ARG1
1.455
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Ligand Name: (2~{r},3~{r},4~{s},5~{r})-2-(6-Aminopurin-9-Yl)-5-[(~{e})-Prop-1-Enyl]oxolane-3,4-Diol Ligand Info
Structure Description Crystal structure of mouse CARM1 in complex with ligand P1C3u PDB:5LGR
Method X-ray diffraction Resolution 2.00 Å Mutation No [3]
PDB Sequence
QNMPGAIRPA
3
A
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .QVR or .QVR2 or .QVR3 or :3QVR;style chemicals stick;color identity;select .E:0 or .E:1; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ILE0
4.742
Residue
Distance (Å)
ARG1
1.456
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Ligand Name: L-prolinamide Ligand Info
Structure Description Crystal structure of mouse CARM1 in complex with ligand P1C3u PDB:5LGR
Method X-ray diffraction Resolution 2.00 Å Mutation No [3]
PDB Sequence
QNMPGAIRPA
3
A
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LPD or .LPD2 or .LPD3 or :3LPD;style chemicals stick;color identity;select .E:3 or .E:4; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ALA3
3.568
Residue
Distance (Å)
ALA4
1.330
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References  Top
REF 1 Recognition of polyadenylate RNA by the poly(A)-binding protein. Cell. 1999 Sep 17;98(6):835-45.
REF 2 Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates. ACS Chem Biol. 2016 Mar 18;11(3):763-71.
REF 3 Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3625-3630.

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