Target Binding Site Detail

Content Navigation (  All   None )                                      
Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T58679 Target Info
Target Name Polyadenylate-binding protein 1 (PABPC1)
Synonyms PABP-1; Poly(A)-binding protein 1
Target Type Clinical trial Target
Gene Name PABPC1
UniProt ID
PABP1_HUMAN
Ligand General Information  Top
Ligand Name L-prolinamide Ligand Info
Canonical SMILES C1CC(NC1)C(=O)N
InChI 1S/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m0/s1
InChIKey VLJNHYLEOZPXFW-BYPYZUCNSA-N
PubChem Compound ID 111306
Drug Binding Sites of Target  Top
PDB ID: 5LGP      Crystal structure of mouse CARM1 in complex with ligand P1C3s
Method X-ray diffraction Resolution 2.04 Å Mutation Yes [1]
PDB Sequence
QNMPGAIRPA
3
A
Residue
Distance (Å)
PRO2
4.839
ALA3
3.166
Residue
Distance (Å)
ALA4
1.330
PDB ID: 5LGR      Crystal structure of mouse CARM1 in complex with ligand P1C3u
Method X-ray diffraction Resolution 2.00 Å Mutation No [1]
PDB Sequence
QNMPGAIRPA
3
A
Residue
Distance (Å)
ALA3
3.568
Residue
Distance (Å)
ALA4
1.330
References  Top
REF 1 Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3625-3630.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.