Target Binding Site Detail
Target General Information | Top | ||||
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Target ID | T58679 | Target Info | |||
Target Name | Polyadenylate-binding protein 1 (PABPC1) | ||||
Synonyms | PABP-1; Poly(A)-binding protein 1 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | PABPC1 | ||||
UniProt ID |
Ligand General Information | Top | ||||
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Ligand Name | (2~{r},3~{r},4~{s},5~{r})-2-(6-Aminopurin-9-Yl)-5-Propyl-Oxolane-3,4-Diol | Ligand Info | |||
Canonical SMILES | CCCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O | ||||
InChI | 1S/C12H17N5O3/c1-2-3-6-8(18)9(19)12(20-6)17-5-16-7-10(13)14-4-15-11(7)17/h4-6,8-9,12,18-19H,2-3H2,1H3,(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 | ||||
InChIKey | BKDAOQOLDUJANJ-WOUKDFQISA-N | ||||
PubChem Compound ID | 117908218 |
Drug Binding Sites of Target | Top | |||||
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PDB ID: 5LGP Crystal structure of mouse CARM1 in complex with ligand P1C3s | ||||||
Method | X-ray diffraction | Resolution | 2.04 Å | Mutation | Yes | [1] |
PDB Sequence |
QNMPGAIRPA
3 A
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PDB ID: 5LGQ Crystal structure of mouse CARM1 in complex with ligand P2C3s | ||||||
Method | X-ray diffraction | Resolution | 2.11 Å | Mutation | No | [1] |
PDB Sequence |
AAPRPPFS
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References | Top | ||||
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REF 1 | Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3625-3630. |
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